Chen, Jianzhu - Massachusetts Institute of Technology - Koch Institute for Integrative Cancer Research

个人简介

Dr. Chen received a BS degree from Wuhan University in China and a PhD in Genetics from Stanford University. He was a post-doctoral fellow and then an instructor at Harvard Medical School before he joined the MIT faculty in the Department of Biology.

研究领域

"We seek to understand the cellular and molecular mechanisms underlying the development and function of the immune system. Our goal is that the knowledge we gain will lead to more effective immunotherapies for cancer and other diseases. Our laboratory studies cellular and molecular mechanisms underlying the interactions between immune cells and cancer and pathogens. We are actively developing engineered natural killer cells for cancer immunotherapy, reprogramming macrophages for treating cancer and metabolic diseases, and developing a mRNA-based vaccine platform for application in SARS CoV-2 and dengue vaccine development.”

近期论文

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Xie G, Dong H, Liang Y, Ham JD, Romee R, Chen J. CAR-nK cells: a promising cellular immunotherapy for cancer. EBioMedicine, accepted. Xie G, Ivica N, Jia B, LI Y, Dong H, Liang Y, Brown D, Romee R, Chen J. Engineered CAR-T cells targeting a neoepitope derived from intracellular NPM1c exhibit potent activity and specificity against human acute myeloid leukemia. Nature Biomedical Engineering, accepted. Romee R, Rosario M, Berrien-Elliott MM, Wagner JA, Jewell BA, Schappe T, Leong JW, Abdel-Latif S, Schneider SE, Willey S, Neal CC, Yu L, Oh ST, Lee YS, Mulder A, Claas F, Cooper MA, Fehniger TA. (2016) Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci Transl Med. 8:357ra123. PMID: 27655849. Hu G, Dong T, Wang S, Jing H, Chen J. (2019) Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function. EBioMedicine, pii: S2352-3964(19)30420-7. PMID: 31278070. Hu G, Su Y, Kang B, Fan Z, Dong T, Brown D, Cheah J, Wittrup KD, Chen J. High throughput phenotypic screen and transcriptional analysis identify new compounds, targets and pathways for macrophage reprogramming. Revised for Nature Communications. Pallasch CP, Leskov I, Braun CJ, Vorholt D, Drake A, Soto-Feliciano YM, Bent EH, Schwamb J, Iliopoulou B, Kutsch N, van Rooijen N, Frenzel LP, Wendtner CM, Heukamp L, Kreuzer KA, Hallek M, Chen J, Hemann MT. (2014) Sensitizing protective tumor microenvironments to antibody-mediated therapy. Cell, 156:590-602. PMID: 24485462. Roghanian A, Hu G, Fraser C, Singh M, Foxall RB, Meyer MJ, Lees E, Huet H, Gleenie MJ, Beers SA, Lim SH, Ashton-Key M, Thirdborough SM, Cragg MS, Chen J. (2019) Cyclophosphamide enhances cancer antibody immunotherapy in the resistant bone marrow niche by modulating macrophage FcgR expression. Cancer Immunol Res. 7:1876-1890. PMID: 31451483. Li Y, Ivica NA, Dong T, Kleyman M, Hu G, Papageorgiou DP, He Y, Chen W, Sullivan LB, Del Rosario A, Hammond PT, Vander Heiden MG, Chen J. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Nature Communications, accepted. Chen Q, Amaladoss A, Ye W, Liu M, Dummler S, Kong F, Wong LH, Loo HL, Loh E, Tan SQ, Tan TC, Chang KTE, Dao M, Suresh S, Preiser PR, Chen J. (2014) Natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. Proc Natl Acad Sci USA, 111:1479-84. PMID: 24474774. Ye W, Chew M, Hou J, Lai F, Leopold SJ, Loo HL, Ghose A, Dutta AK, Chen Q, Ooi EE, White NJ, Dondorp AM, Preiser P, Chen J. (2018) Microvesicles from malaria-infected red blood cells activate natural killer cells via MDA5 pathway. PloS Pathogen, 14:e1007298. PMID: 30286211. Bidet K, Collins CW, Ho V, Choy MM, Wong LH, Naim ANM, Lee YH, Florez de Sessions P, Hibberd ML, Fink K, Ooi EE, Chen J. (2019) Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity. NPJ Vaccines, 4:27. Doi: 10.1038/s4154`-0`9-0``9-3. PMID: 31285858. Hou J, Shrivastava S, Loo HL, Wong LH, Ooi EE, Chen J. (2020) Sequential immunization induces strong and broad immunities against all four serotypes of dengue viruses. NPJ Vaccines, 5:68. doi: 10.1038/s41541-020-00216-0. PMID:32728482.