Cheng, Jianjun - University of Illinois at Urbana-Champaign - Department of Materials Science and Engineering

个人简介

Jianjun Cheng obtained a B.S. degree in Chemistry at Nankai University, China, in 1993, a M.S. degree in Chemistry at Southern Illinois University at Carbondale in 1996, and a Ph.D. degree in Materials Science at the University of California, Santa Barbara in 2001 with Professor Timothy Deming. He was a Senior Scientist at Insert Therapeutics, Inc. from 2001 to 2004, and a Postdoctoral Research Scientist at MIT with Professor Robert Langer from 2004 to 2005. He joined the faculty of the University of Illinois at Urbana-Champaign (UIUC) as a tenure-track Assistant Professor in 2005, and was promoted to Associate Professor in 2011 and Full Professor in 2015. In 2016, he was appointed as Hans Thurnauer Professor of Materials Science and Engineering at UIUC. Cheng is the co-inventor of 41 issued patents and co-authored over 200 publications. Cheng’s research has made translational impact. Two nanomedicine systems he co-developed has made to clinical trials. He received a Prostate Cancer Foundation Competitive Award in 2007, a National Science Foundation CAREER Award in 2008, a Xerox Award for Outstanding Research at UIUC in 2010, a NIH Director’s New Innovator Award in 2010, the Willett Faculty Scholar Award in 2013, and the UIUC Distinguished Promotion Award in 2015. He was appointed as an Associate of Center for Advanced Study at UIUC in 2014. In 2015, he was selected as one of the four inaugural Faculty Entrepreneurial Fellows in the College of Engineering, UIUC. He has also been on the list of Teacher Ranked As Excellent By Students for five times at UIUC. Cheng is Editor-in-Chief of Biomaterials Science, Royal Society of Chemistry, UK. He is a Fellow of the American Institute for Medical and Biological Engineering (2015), a Fellow of American Chemical Society-Division of Polymer Chemistry (2015), a Fellow of American Association for the Advancement of Science (2016), and a Fellow of National Academy of Inventors (2020).

研究领域

Nanomedicine A major research focus in the Cheng Research Group is to develop therapeutic nanomedicine. We are interested in several platforms and directions. Polymer-drug conjugate has been one of the major platforms for the design of drug delivery systems and the development of new therapeutics. We have worked on drug-initiated ring-opening polymerization for the synthesis of polylactide-drug conjugate and nanoconjugates. We have developed size well controlled silica-drug nanoconjugates and explored the size-distribution and size-efficacy correlation. We also developed the concept of chain-shattering polymeric therapeutics. We are interested in cancer targeting and has developed aptamer mediated cancer targeting. We will continue working in this area and aim to develop novel chemistry for making advanced materials and systems that allow efficiency delivery of therapeutics in vitro and in vivo. Drug-polymer conjugate via controlled ring-opening polymerization Nanomedicine with controlled size for improved drug delivery and cancer targeting Chain-shattering polymeric therapeutics Polypeptides: Synthesis, Structural Control and Applications Polypeptide synthesis via ROP of NCA, helical charged polypeptide, gene/siRNA delivery Self-healing Materials Based on Hindered Urea Bonds A new direction in the Cheng Research Group is to develop hindered urea bond containing materials. Hindered urea bonds can reversibly dissociate into isocyanante and amine, which form equilibrium with the urea bond via rapid exchange reactions. Based on this dynamic chemistry, we development polyurea and poly(urethane-urea) materials that display remarkable catalyst-free self-healing property at low temperature.

近期论文

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Lv, S., Kim, H., Feng, L., Song, Z., Yang, Y., Baumgartner, R., Tseng, K.-Y., Dillon, S., Leal, C., Yin, L., Cheng, J. “Unimolecular Polypeptide Micelles via Ultra-fast Polymerization of N-Carboxyanhydrides”, J. Am. Chem. Soc. 2020, 142, 19, 8570-8574. Song, Z.; Fu, H.; Baumgartner, R.; Zhu, L.; Shih, K.; Xia, Y.; Nieh, M., Chipot, C.; Lin, Y.; Cheng, J. “Enzyme-mimetic, self-catalyzed polymerization of polypeptide helices”, Nature Communications, 2019, 10, 5470. Song, Z.; Fu, H.; Wang, J.; Hui, J.; Xue, T.; Pacheco, L.A.; Yan, H.; Baumgartner, R.; Wang, Z.; Xia, Y.; Wang, X.; Yin, L.; Chen, C.; Rodríguez-Lópezd, J.; Ferguson, A.; Lin, Y.; Cheng, J. “Synthesis of polypeptides via bioinspired polymerization of in situ purified N-carboxyanhydrides”, PNAS, 2019, 116, 10658-10663 Chen, C.; Fu, H.; Baumgartner, R.; Song, Z.; Lin, Y.; Cheng, J. “Proximity-Induced Cooperative Polymerization in “Hinged” Helical Polypeptides”, J. Am. Chem. Soc., 2019, 141, 8680-8693 Wang, H.; Song, Z.; Lao, Y.; Xu, X.; Gong, J.; Cheng, D.; Chakraborty, S.; Park, J.S.; Li, M.; Huang, D.; Yin, L.; Cheng, J.; Leong, K.W. “Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide”, PNAS, 2018, 115, 4903-4908 Lv, S. Wu, Y., Cai, K. He, H. Li, Y.; Lan, M.; Chen, X.; Cheng, J.; Yin, L. “High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor-Receptor Coordination Interactions” J. Am. Chem. Soc., 2018, 140, 1235–1238 Zhang, Y.; Cai, K.; Li, C.; Guo, Q.; Chen, Q.; He, X.; Liu, L.; Zhang, Y.; Lu, Y.; Chen, X.; Sun, T.; Huang, Y.; Cheng, J.; Jiang, C. “Macrophage Membrane-Coated Nanoparticles for Tumor-Targeted Chemotherapy”, Nano Lett., 2018, 18, 1908-1915 Song, Z., Fu, H.; Wang, R.; Pacheco, L.; Wang, X.; Lin, Y.; Cheng, J. “Secondary structures in synthetic polypeptides from N-carboxyanhydrides: design, modulation, association, and material applications”, Chemical Society Reviews, 2018, 47, 7401-7425. Wang, H.; Wang, R.; Cai, K.; He H.; Liu, Y.; Yen, J.; Wang, Z.; Xu, M.; Sun, Y.; Zhou, X.; Yin, Q.; Tang, L.; Dobrucka, I.; Dobrucki, L.; Chaney, E.; Boppart, S.; Fan, T.; Lezmi, S.; Chen, X.; Yin, L.; Cheng, J. “Selective In Vivo Cell Labeling Mediated Cancer Targeting”, Nature Chemical Biology, 2017, 13, 415-424. Baumgartner, R., Fu, H.; Song, Z.; Lin, Y.; Cheng, J. “Cooperative polymerization of α-helices induced by macromolecular architecture”, Nature Chemistry, 2017, 9, 614–622 Xiong M.; Bao Y.; Xu, X.; Wang, H.; Han, Z.; Wang, Z.; Liu, Y.; Huang, S.; Song. Z; Chen, J.; Peek, R.M. Jr., Yin, L.; Chen, L.; Cheng, J. “Selective Killing of Helicobacter pylori with pH-Responsive Helix-Coil Conformation Transitionable Antimicrobial Polypeptides”. PNAS, 2017, 114, 12675-12680 Song, Z.; Mansbach, RA; He, H.; Shik, KC; Baumgartner, R.; Zheng, N.; Ba, X.; Huang, Y.; Mani, D.; Nieh, MP; Ferguson, AL; Yin, L.; Cheng, J. “Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands”, Nature Communications., 2017, 8, 92 Song, Z.; Han, Z.; Lv, S.; Chen, C.; Chen, L.; Lin, Y.; Cheng, J. “Synthetic polypeptides: from polymer design to supramolecular assembly and biomedical application”. Chemical Society Reviews, 2017, 46, 6570-6599 Xiong, M.; Han, Z.; Song, Z.; Yu, J.; Ying, H.; Yin, L; Cheng, J. “Bacteria-Assisted Activation of Antimicrobial Polypeptides via Random Coil-to-Helix Transition”, Angew Chem. Int. Ed., 2017, 56, 10826-10829 Xia, H.; Fu, H.; Zhang, Y.; Shih, K.; Ren, Y.; Anuganti, M.; Nieh, M; Cheng, J.; Lin, Y. “Supramolecular Assembly of Comb-like Macromolecules Induced by Chemical Reactions that Modulate the Macromolecular Interactions in-situ”, J. Am. Chem. Soc., 2017, 139, 11106–11116 Chen, J.; Ding, J.; Wang, Y.; Cheng, J.; Ji, S.; Zhuang, X.; Chen, X. “Sequentially Responsive Shell-Stacked Nanoparticles for Deep Penetration into Solid Tumors”, Advanced Materials, 2017, 29, 201701170 Lee, MW; Han, M.; Bossa GW; Snell, C.; Song, Z.; Tang T.; Yin, L.; Cheng, J.; May, S.; Luijten, E.; Wong, GCL “Interactions between Membranes and “Metaphilic” Polypeptide Architectures with Diverse Side-Chain Populations”, ACS Nano, 2017, 11, 2858-2871. Bao, Y.; Wu, X.; Chen, J.; Hu, X.; Zeng, F.; Cheng, J.; Jin, H. Lin, X.; Chen, L. “Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα”. PNAS, 2017, 114(20): E3993-E4001. Wang, H.; Gauthier, M.; Kelly, J. R.; Miller, R.J.; Xu, M.; O’Brien, W.D.; Cheng, J. “Targeted Ultrasound Assisted Cancer-Selective Chemical Labeling and Subsequent Cancer Imaging via Click Chemistry”, Angew Chem. Int. Ed. 2016, 55, 5452-5456 Wang, R.; Xu, Y.; Zhang, J.; Cheng, J. Tong, R. “β-Diiminate Zinc Catalyst for Controlled Ring-Opening Polymeriza-tion of O-Carboxyanhydrides”, Angew Chem. Int. Ed., 2016, 55, 13010-130114