Need, Eleanor - University of Adelaide

研究领域

Biology of steroid receptor action Estrogen and progesterone action in breast cancer Breast Cancer Androgen action in men Prostate Cancer

近期论文

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Bianco-Miotto, T., A. P. Trotta, E. F. Need, A. M. Lee, A. M. Ochnik, L. Giorgio, . . . G. Buchanan (2014). Molecular and structural basis of androgen receptor responses to dihydrotestosterone, medroxyprogesterone acetate and Delta(4)-tibolone. Mol Cell Endocrinol 382(2): 899-908. Leach, D. A., E. F. Need, A. P. Trotta, M. J. Grubisha, D. B. DeFranco and G. Buchanan (2014). Hic-5 influences genomic and non-genomic actions of the androgen receptor in prostate myofibroblasts. Mol Cell Endocrinol 384(1-2): 185-199. Need, E. F., V. Atashgaran, W. V. Ingman and P. Dasari (2014). Hormonal regulation of the immune microenvironment in the mammary gland. J Mammary Gland Biol Neoplasia19(2): 229-239. Ellem, S. J., R. A. Taylor, L. Furic, O. Larsson, M. Frydenberg, D. Pook, . . . G. P. Risbridger (2014). A pro-tumourigenic loop at the human prostate tumour interface orchestrated by oestrogen, CXCL12 and mast cell recruitment. J Pathol 234(1): 86-98. Trotta, A. P., E. F. Need, L. A. Selth, S. Chopra, C. B. Pinnock, D. A. Leach, . . . G. Buchanan (2013). Knockdown of the cochaperone SGTA results in the suppression of androgen and PI3K/Akt signaling and inhibition of prostate cancer cell proliferation. Int J Cancer 133(12): 2812-2823. Harada, T., L. Giorgio, T. J. Harris, D. T. Pham, H. T. Ngo, E. F. Need, . . . T. W. Kee (2013). Diamide linked gamma-cyclodextrin dimers as molecular-scale delivery systems for the medicinal pigment curcumin to prostate cancer cells. Mol Pharm10(12): 4481-4490. Trotta, A.P., E.F. Need, L.M. Butler, L.A. Selth, M.A. O'Loughlin, G.A. Coetzee, et al., Subdomain structure of the co-chaperone SGTA and activity of its androgen receptor client. J Mol Endocrinol, 2012. 49(2): p. 57-68. Need, E.F., L.A. Selth, T.J. Harris, S.N. Birrell, W.D. Tilley, and G. Buchanan, Research resource: interplay between the genomic and transcriptional networks of androgen receptor and estrogen receptor alpha in luminal breast cancer cells. Mol Endocrinol, 2012. 26(11): p. 1941-52. Lawrence, M.G., C.R. Stephens, E.F. Need, J. Lai, G. Buchanan, and J.A. Clements, Long terminal repeats act as androgen-responsive enhancers for the PSA-kallikrein locus. Endocrinology, 2012. 153(7): p. 3199-210. Buchanan, G., E.F. Need, J.M. Barrett, T. Bianco-Miotto, V.C. Thompson, L.M. Butler, et al., Corepressor effect on androgen receptor activity varies with the length of the CAG encoded polyglutamine repeat and is dependent on receptor/corepressor ratio in prostate cancer cells. Mol Cell Endocrinol, 2011. Need, E.F., P.D. O'Loughlin, D.T. Armstrong, M.T. Haren, S.A. Martin, W.D. Tilley, et al., Serum testosterone bioassay evaluation in a large male cohort. Clin Endocrinol (Oxf), 2010. 72(1): p. 87-98. Diener, K.R., E.F. Need, G. Buchanan, and J.D. Hayball, TGF-beta signalling and immunity in prostate tumourigenesis. Expert Opin Ther Targets, 2010. 14(2): p. 179-92. Need, E.F., H.I. Scher, A.A. Peters, N.L. Moore, A. Cheong, C.J. Ryan, et al., A novel androgen receptor amino terminal region reveals two classes of amino/carboxyl interaction-deficient variants with divergent capacity to activate responsive sites in chromatin. Endocrinology, 2009. 150(6): p. 2674-82. Chmelar, R., G. Buchanan, E.F. Need, W. Tilley, and N.M. Greenberg, Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Int J Cancer, 2007. 120(4): p. 719-33. Thornton, J.W., E. Need, and D. Crews, Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling. Science, 2003. 301(5640): p. 1714-7.