个人简介

2011-present Professor and Director, Harper Cancer Research Institute, University of Notre Dame 2007-2011 Professor and Vice-Chair for Research,University of Missouri School of Medicine 2006-2007 Professor,Northwestern University Medical School 2000-2006 Associate Professor,Northwestern University Medical School 1994-2000 Assistant Professor, Northwestern University Medical School 1991-1994 Assistant Research Professor, Duke University Medical Center 1989-1991 Postdoctoral Research Associate, Duke University Medical Center 1989 Ph.D. in Biochemistry, University of Louisville 1985 M.S. in Biomedical Sciences/Biochemistry, East Tennessee State University 1981 B.S. in Biochemistry, Clemson University Award: 2012 Elected Fellow, American Association for the Advancement of Science 2011 Ann F. Dunne and Elizabeth Riley Director, Harper Cancer Research Institute 2008 Mulligan Endowed Professor of Cancer Research, University of Missouri

研究领域

Biochemistry

The ability to invade host tissues and metastasize is the major cause of cancer-related death. During tumor invasion, metastasizing cells disrupt normal cell-cell and cell-matrix contacts and acquire a migratory, invasive phenotype. Thus modulation of cell-cell and cell-matrix adhesive events likely plays a critical role in tissue remodeling during tumor progression. Subsequent alterations in cellular architecture mediated by modified extracellular matrix (ECM) attachments induce expression of proteinases that degrade ECM proteins, facilitating migration through the modified tissue to establish metastatic foci and removing matrix constraints that normally limit proliferation. Although malignant cells produce a spectrum of matrix-degrading enzymes, predominant among these proteinases are enzymes in the plasminogen activator (PA) and matrix metalloproteinase (MMP) families. Current research centers on regulation of these proteinase families in two model systems: epithelial ovarian carcinoma and squamous cell carcinoma of the oral cavity. Ongoing research utilizes an integrative approach involving examination of 2-dimensional (2D) and 3D tissue culture systems and organotypic cultures complemented by murine tumor models and analyses of human tumors. Understanding the molecular mechanisms by which tumor cells orchestrate multiple microenvironmental cues to regulate the expression and activity of metastasis-associated proteinases is the major focus of the laboratory. Additional collaborative research with Dr. Laurie Hudson (Univ. of New Mexico) is examining areas of convergence between epidermal growth factor receptor (EGFR) and cell adhesion (cadherin and integrin) signaling pathways in ovarian carcinoma metastatic dissemination. Collaborative research with Dr. Matthew Ravosa (Univ. of Notre Dame) focuses on the relationship between mechanical loading and tissue remodeling in development and ageing of the masticatory apparatus.

近期论文

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Lengyel E, Burdette JE, Kenny HA, Matei D, Pilrose J, Haluska P, Nephew KP, Hales DB, Stack MS (2013) Epithelial ovarian cancer experimental models. Oncogene. 2013 Aug 12. doi: 10.1038/onc.2013.321. [Epub ahead of print] PubMed Link Barbolina MV, Liu Y, Gurler H, Kim M, Kajdacsy-Balla AA, Rooper L, Shepard J, Weiss M, Shea LD, Penzes P, Ravosa MJ, Stack MS (2013) Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein. J Biol Chem 288:141-51. PubMed Link. Miller DL, Puricelli MD, Stack MS (2012) Virology and molecular pathogenesis of HPV (human papillomavirus)-associated oropharyngeal squamous cell carcinoma. Biochem J. 443:339-53. PubMed Link. Burkhalter R, Symowicz J, Hudson LG, Gottardi CJ and Stack MS (2011) Integrin regulation of beta-catenin signaling in ovarian carcinoma. J Biol Chem 286: 23467-75. PubMed Link. Jiang R, Shi Z, Johnson JJ, Liu Y, and Stack MS (2011) Kallikrein-5 promotes cleavage of desmoglein-1 and loss of cell-cell cohesion in oral squamous cell carcinoma. J Biol Chem 286: 9127-35. PubMed Link.