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Campaniello MA, Harrington AM, Martin CM, Blackshaw LA, Brierley SM, Hughes PA (2016) Activation of colo-rectal high-threshold afferent nerves by interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity. Neurogastroenterol. and Motility. Jan 28(1):54-63 Mikocka-Walus A, Bampton P, Hetzel D, Hughes P, Esterman A, Andrews JM (2015) Cognitive-havaioural therapy has no effect on disease activity but improves quality of life in subgroups of patients with inflammatory bowel disease: a pilot randomised controlled trial. BMC Gastroenterol. May 2; 15:54 Hughes PA, Moretta M, Lim A, Grasby DJ, Bird D, Brierley SM, Liebregts T, Adam B, Blackshaw LA, Holtmann G, Bampton P, Hoffman P, Andrews JM, Zola H, Krumbiegel D (2014) Immune derived opioidergic inhibition of viscerosensory afferents is decreased in Irritable Bowel Syndrome patients. Brain, Behaviour and Immunity. Nov 42:191-203. ERA A. IF 6.1. F1000 recommended. Malsch P, Andratsch M, Vogl C, Link A, Alzheimer C, Brierley SM, Hughes PA, Kress M (2014) Deletion of Interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1. J. Neurosci. Jul 23;34(30):9845-56. ERA A* IF 7.12. Hughes PA, Castro J, Harrington AM, Isaacs N, Moretta M, Hicks GA, Urso DM, Brierley SM. (2014) Increased κ-opioid receptor expression and function during chronic visceral hypersensitivity. Gut. Jul;63(7):1199-200. ERA A* IF 13.3. Castro J, Harrington AM, Hughes PA, Martin CM, Ge P, Shea CM, Jin H, Jacobson S, Hannig G, Mann E, Cohen MB, Macdougall JE, Lavins BJ, Kurtz CB, Silos-Santiago I, Johnston JM, Currie MG, Blackshaw LA, Brierley SM. (2013) Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-c and extracellular cyclic GMP. Gastroenterology. Dec;145(6):1334-46. ERA A* IF 13.9. (Highlighted in Nature Reviews Gastroenterology and Hepatology) Hughes PA, Harrington AM, Castro J, Liebregts T, Adam B, Grasby DJ, Issacs NJ, Maldeniya L, Martin CM, Persson J, Andrews JM, Holtmann G, Blackshaw LA, Brierley SM. (2013) Sensory neuro-immune interactions differ between IBS subtypes. Gut. 62(10):1456-65. ERA A*. IF 13.3 (Highlighted in Nature Reviews Gastroenterology and Hepatology). F1000 recommended Harrington AM, Brierley SM, Isaacs N, Hughes PA, Castro J, Blackshaw LA (2012) Sprouting of colonic afferent central terminals and increased spinal MAP kinase expression in a mouse model of chronic visceral hypersensitivity. J. Comp. Neurol. 520(10):2241-55. ERA A*. IF 3.9 F1000 recommended Brierley SM, Castro J, Harrington AM, Hughes PA, Page AJ, Rychkov GY, Blackshaw LA (2011) TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. J. Phys. 589(14):3575-93. ERA A*. IF 4.8 Harrington AM, Hughes PA, Martin CM, Yang J, Castro J, Issacs NJ, Blackshaw LA and Brierley SM (2011) A novel role for TRPM8 in visceral afferent function. Pain 152(7); 1459-68 ERA A. IF 5.35 Brierley SM*, Hughes PA*, Page AJ*, Kwan KY, Martin CM, O’Donnell TA, Cooper NJ, Harrington AM, Adam B, Liebregts T, Holtmann G, Corey DP, Rychkov GY, Blackshaw LA. (2009) The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology. 137(6);2084-2095. ERA A* IF 12.03 (selected for Faculty of 1000 biology) Hughes PA*, Brierley SM*, Martin CM, Brookes SJH, Linden DR, Blackshaw LA. (2009) Post inflammatory colonic afferent sensitization: different subtypes, different pathways, and different time-courses. Gut. 58(10):1333-41 ERA A* I.F. 10.6 Hughes PA, Brierley SM, Martin CM, Liebregts T, Adam B, Persson J, Holtmann G, Blackshaw LA. (2009) TRPV1-expressing sensory fibres and IBS: links with immune function. Gut. 58(3): 465-456. ERA A* I.F. 10.6 Brierley SM*, Page AJ*, Hughes PA*, Adam B, Liebregts T, Cooper NJ, Holtmann G, Liedtke W, Blackshaw LA. (2008). Selective Role for TRPV4 Ion Channels in Visceral Sensory Pathways. Gastroenterology. 134(7):2059-69. ERA A* IF 12.03 Lindstrom E, Brusberg M, Hughes PA, Martin CM, Brierley SM, Phillis BD, Martinsson R, Abrahamsson C, Larsson H, Martinez V, Blackshaw LA. (2007). Involvement of metabotropic glutamate 5 receptor in visceral pain. Pain. 137(2):295-305. ERA A I.F. 5.35 Page, AJ, Brierley SM, Martin CM, Hughes PA, Blackshaw LA. (2007). Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain 133 (1-3):150-160. ERA A I.F. 5.35 Hughes PA*, Brierley SM*, Young RL and Blackshaw LA. (2007). Localization and comparative analysis of acid-sensing ion channel (ASIC1, 2, and 3) mRNA expression in mouse colonic sensory neurons within thoracolumbar dorsal root ganglia. J. Comp. Neurol. 500(5):863-75. ERA A* I.F. 3.9 Callaghan PD, Farrand K, Salem A, Hughes P, Daws LC and Irvine RJ. (2006) Repeated administration of the substituted amphetamine p-methoxyamphetamine (PMA) produces reductions in cortical 5-HT transporter binding but not 5-HT content, unlike 3,4-methylenedioxyamethamphetamine (MDMA). Eur. J. Pharm. 546(1-3):74-81. ERA B I.F. 2.37 De la Lande I, Stepein J, Philpott A, Hughes PA, Stafford I and Horowitz J (2004) Aldehyde dehydrogenase, nitric oxide synthase and superoxide in ex vivo nitrate tolerance in rat aorta. Eur. J. Pharm. 496(1-3):141-149. ERA B I.F. 2.37