个人简介

1999-present Professor, University of Notre Dame 1988-1999t Associate Professor, University of Notre Dame 1982-1988 Assistant Professor, University of Notre Dame 1980-1982 Postdoctoral Research Associate, Cornell University 1980 Ph.D. in Biochemistry, Michigan State University 1975 B.S. in Biochemistry, Albright College Award: 2012 Elected Fellow, Royal Society of Chemistry 2012 Elected Fellow, American Chemical Society 2010 Elected Fellow, American Association for the Advancement of Science 2006 Melville L. Wolfrom Award in Carbohydrate Chemistry, ACS Division of Carbohydrate Chemistry 2003 Kaneb Teaching Award 2001 John A. Boezi Memorial Alumnus Award, Michigan State University

研究领域

Biochemistry/Organic Chemistry

Professor Serianni's research focuses on the use of stable isotopically-labeled compounds to examine structure, conformation and reactivity of carbohydrates and nucleic acids in solution using modern multidimensional NMR methods and computational techniques. His group is interested in developing and improving chemical and chemi-enzymic methods to prepare carbohydrate-containing biomolecules containing one or more sites of isotopic enrichment, with 13C, 2H and 15N of primary concern. NMR studies of these labeled biomolecules permit a more detailed assessment of their 3-D structures in solution, information which is critical to understanding the fundamental factors controlling molecular recognition in biological processes. Of current interest is the use of stable isotopes in the assessment of DNA and RNA structure in solution. Research is under way to: a) develop efficient chemical, chemi-enzymic, and/or biological methods to introduce isotopes selectively or uniformly into nucleosides and oligonucleotides, b) apply 2-D and 3-D NMR methods to decipher the NMR spectra of labeled oligonucleotides, and c) assess the merits of 13C-1H and 13C-13C spin-coupling constants within the furanose rings of RNA and DNA as structural probes. NMR data are complemented and extended by ab initio molecular orbital calculations which can assess the energetics and structural features of furanose ring pseudorotation and predict 13C-1H and 13C-13C spin-couplings for various pathways in these rings, and by X-ray crystallography. The long range objective is to apply this information to NMR solution studies of CCAAT-containing oligonucleotides involved in the NF-1 recognition site at the origin of replication of human adenovirus, and other biologically-important DNA and RNA oligomers. Other work involves studies of carbohydrate metabolism via in vivo 13C and 19F NMR spectroscopy, and the development of automated devices for chemical and biological synthesis of labeled biomolecules.

近期论文

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B. Bose, S. Zhao, P. Bondo, G. Bondo, F. Cloran, I. Carmichael, R. Stenutz, B. Hertz and A.S. Serianni, Three-Bond C-O-C-C Spin-Coupling Constants in Carbohydrates: Development of a Karplus Relationship, J. Am. Chem. Soc. 1998, 120, 11158-11173. W.S. Hays, D.J. VanderJagt, B. Bose, A.S. Serianni and R.H. Glew, Catalytic Mechanism and Specificity for Hydrolysis and Transglycosylation Reactions of Cytosolic beta-Glucosidase from Guinea Pig Liver, J. Biol. Chem. 1998, 273, 34941-34948. A. S. Serianni, Carbohydrate Structure, Conformation and Reactivity: NMR Studies with Stable Isotopes, in Bioorganic Chemistry: Carbohydrates, S. Hecht, ed., Oxford University Press, 1999. F. Cloran, I. Carmichael and A.S. Serianni, 13C-1H and 13C-13C Spin-Coupling Behavior in Aldofuranosyl Rings from Density Functional Theory, J. Phys. Chem. 1999, 103A, 3783-3795. H. Junicke, C. Bruhn, R. Kluge, A.S. Serianni and D. Steinborn, Novel Platinum(IV)-Carbohydrate Complexes: Metal Ion Coordination Behavior of Monosaccharides in Organic Solvents, J. Am. Chem. Soc. 1999, 121, 6232-6241. Z. Hricoviniova-Bilikova, M. Hricovini, M. Petrusova, A.S. Serianni and L. Petrus, Stereospecific Molybic Acid-Catalyzed Isomerization of 2-Hexuloses to Branched-Chain Aldoses, Carbohydr. Res. 1999, 319, 38-46. R. Stenutz, M. Shang and A.S. Serianni, Methyl beta-Lactoside (methyl 4-O-beta-D-galactopyranosyl-beta-D-glucopyranoside) Methanol Solvate, Acta Crystal. 1999, C55, 1719-1721. F. Cloran, I. Carmichael and A.S. Serianni, DFT Calculations on Disaccharide Models: Studies of Molecular Geometries and Trans-O-Glycoside 3JCOCH and 3JCOCH Spin-Couplings, J. Am. Chem. Soc. 1999, 121, 9843-9851. F. Cloran, I. Carmichael and A.S. Serianni, 2JCOC Spin-Coupling Constants Across Glycosidic Linkages Exhibit a Valence Bond-Angle Dependence, J. Am. Chem. Soc. 2000, 122, 396-397. H. Junicke, A.S. Serianni and D. Steinborn, Platinum(IV)-Carbohydrate Complexes: Structure Determination Based on 1H-1H, 13C-1H and 13C-13C Spin-Spin Coupling Constants, J. Org. Chem. 2000, 65, 4153-4161. B. Bose-Basu, J. Zajicek, G. Bondo, S. Zhao, M. Kubsch, I. Carmichael, and A.S. Serianni, Deuterium Spin-Lattice Relaxation Times and Quadrupolar Coupling Constants in Isotopically-Labeled Saccharides, J. Magn. Reson. 2000, 144, 207-216. F. Cloran, I. Carmichael and A.S. Serianni, 2-Deoxy-beta-D-erythro-pentofuranosylamine: Quantum Mechanical Calculations of Molecular Structure and NMR Spin-Spin Coupling Constants in Nitrogen-Containing Saccharides, J. Am. Chem. Soc. 2000, 122, 6435-6448.