个人简介

2010-present Concurrent Assistant Professor, Department ofChemical and Biomolecular Engineering, University of Notre Dame 2009-present Assistant Professor, University of Notre Dame 2007-2009 Research Fellow, National Institute of Diabetes and Digestive and Kidney Diseases, NIH 2005-2007 NRC Postdoctoral Fellow, National Institute of Standards and Technology 2005 Ph.D. in Analytical Chemistry, University of Illinois at Urbana-Champaign 2000 B.S. in Chemistry, The Ohio State University Award: 2013 Cottrell Scholar Award 2008 NIH Pathway to Independence Award

研究领域

Biochemistry/Physical/Analytical Chemistry

Research in the Schultz lab aims at developing instrumentation and methodology to detect and analyze molecules in complex samples, often relevant to biomedical problems. We are interested in understanding how the spatial organization of molecules affects their behavior. We utilize laser spectroscopy, including nonlinear spectroscopic methods, and also spectroscopic imaging modalities such as Raman near-field scanning optical microscopy, which is capable of vibrational spectroscopic imaging with a spatial resolution of tens of nanometers. Many of the tools developed in our laboratory use tandem measurement, such as combining electrochemistry with Raman detection to both quantify and identify analytes. One area of emphasis in our lab is increased understanding and the application of localized surface plasmon resonances in metal nanostructures, which are known to give rise to signal enhancements in Raman spectroscopy. Our laboratory has been investigating new approaches to utilizing these enhancements for determining protein - ligand interactions that are common drug targets and regulate signaling processes in cellular membranes. Additionally, nanostructure arrays are being investigated for label-free detection of molecules, particles, and supramolecular assemblies in solution. The chemical information in a Raman spectrum suggests routes to new multivariate biomarkers for disease.

近期论文

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Negri, P., Sarver, S. A., Schivaone, N. M., Dovichi, N. J., Schultz, Z. D. "Online SERS detection and characterization of eight biologically-active peptides separated by capillary zone electrophoresis" Analyst, Advanced Article Link Wang, H., Carrier, S., Park, S., Schultz, Z. D. "FD 178: Selective TERS Detection and Imaging through Controlled Plasmonics" Faraday Discussions, DOI : 10.1039/C4FD00190G, Link Wang, H., Schultz, Z. D. "TERS Detection of αvβ3 Integrins in Intact Cell Membranes" ChemPhysChem, 15(18), 2014, 3944-3949, Link Schultz, Z.D., Book review: "Yukihiro Ozaki, Katrin Kneipp, Ricardo Aroca (Eds.): Frontiers of surface-enhanced Raman scattering: single nanoparticles to single cells" Analytical and Bioanalytical Chemistry, 406(25), 2014, 6083-6084, Link Schultz, Z.D., "Submolecular Spectroscopy?" J. Physical Chemistry Letters, 5(18), 2014, 3279-3280, Link Negri, P., Schultz, Z. D. "Online SERS detection of the 20 proteinogenic L-amino acids separated by capillary zone electrophoresis" Analyst, 139(22), 2014, 5989-5998, Link Schultz, Z. D., Marr, J. M., Wang, H. "Tip enhanced Raman scattering: plasmonic enhancements for nanoscale chemical analysis" Nanophotonics, 3(1-2), 2014, 91-104, Link Asiala, S. M., Schultz, Z. D. "Surface Enhanced Correlation Spectroscopy of Particles in Solution" Analytical Chemistry, 86(5), 2014, 2625-2632, Link Negri, P., Flaherty, R. J., Dada, O.O., Schultz, Z. D. "Ultrasensitive online SERS detection of structural isomers separated by capillary zone electrophoresis" Chemical Communications, 50(21), 2014, 2707-2710, Link Antonio, K. A., Schultz, Z. D. "Advances in Biomedical Raman Microscopy" Analytical Chemistry, 86(1), 2014, 30-46, Link Negri, P., Jacobs, K. T., Dada, O.O., Schultz, Z. D. "Ultrasensitive SERS Flow Detector Using Hydrodynamic Focusing" Analytical Chemistry, 85(21), 2013, 10159-10166, Link Marr, J. M., Schultz, Z. D. "Imaging Electric Fields in SERS and TERS Using the Vibrational Stark Effect" Journal of Physical Chemistry Letters, 4(19), 2013, 3268-3272, Link and Live Slides Wang, H., Schultz, Z. D. "The chemical origin of enhanced signals from tip-enhanced Raman detection of functionalized nanoparticles" Analyst, 138(11), 2013, 3150-3157, Link Asiala, S. M., Schultz, Z. D. "Label-free in situ detection of individual macromolecular assemblies by surface enhanced Raman scattering" Chemical Communications, 49(39), 2013, 4340-4342, Link Alexander, K. D., Schultz, Z. D. "Tip Enhanced Raman Detection of Antibody Conjugated Nanoparticles on Cellular Membranes" Analytical Chemistry, 84(17), 2012, 7408-7414, Link Marr, J. M., Li, F., Petlick, A., Schafer, R., Hwang, C., Chabot, A., Ruggiero, S., Tanner, C. E., Schultz, Z. D. "The Role of Lateral Tension in Calcium induced DPPS Vesicle Rupture." Langmuir, 28(32), 2012, 11883-11889, Link Asiala, S. M., Schultz, Z. D. "Characterization of hotspots in a highly enhancing SERS substrate." Analyst, 136(21), 2011, 4472-4479, Link Carrier, S., Kownacki, C. M., Schultz Z. D. "Protein-Ligand Binding Investigated by a Single Nanoparticle-TERS Approach." Chemical Communications, 47(7), 2011, 2065-2067, Link Schultz, Z.D., Levin, I. W. "Vibrational Spectroscopy of Biomembranes." Annual Reviews of Analytical Chemistry, 2011, 4, 343-366 Link Schultz, Z.D. "Raman Spectroscopic Imaging of Cholesterol and Docosahexaenoic Acid Distribution in the Retinal Rod Outer Segment." Australian Journal of Chemistry, 64(5), 2011, 611-616, Invited Article, Link