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Prevention of type 1 diabetes Prevention of vascular complications from childhood

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Marcovecchio ML, Woodside J, Jones T, Daneman D, Neil A, Prevost T, Dalton RN, Deanfield J, Dunger D; on behalf of the AdDIT Investigators.. Adolescent Type 1 Diabetes cardio-renal Intervention Trial (AdDIT): Urinary screening and baseline biochemical and cardiovascular assessments. Diabetes Care. 2013 Nov 6 Megan AS Penno, Jennifer J Couper, Maria E Craig, Peter G Colman, William D Rawlinson, Andrew M Cotterill, Timothy W Jones, ENDIA Study Group and Leonard C Harrison Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes BMC Pediatr 2013 ; epub. Anderson J, Pe?a AS, Sullivan T, Gent R, D Arcy B, Olds T, Coppin B, Couper J. Does metformin improve vascular heath in children with type 1 diabetes? Protocol for a one year, double blind, randomised, placebo controlled trial. BMC Pediatr. 2013 16;13(1):108. Cameron F, Cotterill A, Couper J, Craig M, Davis E, Donaghue K, Jones T, King B, Sheil B. Short report: Care for children and adolescents with diabetes in Australia and New Zealand: have we achieved the defined goals?J Paediatr Child Health. 2013 49(4): 258-62. Harrington J, Pena A, Baghurst P, Gent R, Wilson L, Couper J Vascular function and glucose variability improve transiently following initiation of continuous subcutaneous insulin infusion in children with type 1 diabetes. Pediatr Diabetes. 2013 Pena A, Maftei O, Wiltshire E, Dowling K, Gent R, Mackenzie K, Couper JJ. Folate fortification and supplementation does not provide vascular health benefits in type 1 diabetes J Pediatr 2013 163(1):255-60 Howson JM, Cooper JD, Smyth DJ, Walker NM, Stevens H, She JX, Eisenbarth GS, Rewers M, Todd JA, Akolkar B, Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Nierras C, Pociot F, Rich SS; and the Type 1 Diabetes Genetics Consortium. Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes. Diabetes. 2012 Nov;61(11):3012-7. Harrington J, Pe?a AS, Gent R, Hirte C, Couper J.Adolescents with congenital adrenal hyperplasia because of 21-hydroxylase deficiency have vascular dysfunction. Clin Endocrinol (Oxf). 2012 Jun;76(6):837-42. Hunt KA, Smyth DJ, Balschun T, Ban M, Mistry V, Ahmad T, Anand V, Barrett JC, Bhaw-Rosun L, Bockett NA, Brand OJ, Brouwer E, Concannon P, Cooper JD, Dias KR, van Diemen CC, Dubois PC, Edkins S, F?lster-Holst R, Fransen K, Glass DN, Heap GA, Hofmann S, Huizinga TW, Hunt S, Langford C, Lee J, Mansfield J, Marrosu MG, Mathew CG, Mein CA, Müller-Quernheim J, Nutland S, Onengut-Gumuscu S, Ouwehand W, Pearce K, Prescott NJ, Posthumus MD, Potter S, Rosati G, Sambrook J, Satsangi J, Schreiber S, Shtir C, Simmonds MJ, Sudman M, Thompson SD, Toes R, Trynka G, Vyse TJ, Walker NM, Weidinger S, Zhernakova A, Zoledziewska M; Type 1 Diabetes Genetics Consortium; UK Inflammatory Bowel Disease (IBD) Genetics Consortium; Wellcome Trust Case Control Consortium, Weersma RK, Gough SC, Sawcer S, Wijmenga C, Parkes M, Cucca F, Franke A, Deloukas P, Rich SS, Todd JA, van Heel DA.Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry.Nat Genet. 2011 Dec 27;44(1):3-5. Pe?a AS, Couper JJ, Harrington J, Gent R, Fairchild J, Tham E, Baghurst P.Hypoglycemia, but not glucose variability, relates to vascular function in children with type 1 diabetes. Diabetes Technol Ther. 2012 Jun;14(6):457-62. Hilner JE, Perdue LH, Sides EG, Pierce JJ, W?gner AM, Aldrich A, Loth A, Albret L, Wagenknecht LE, Nierras C, Akolkar B; Type 1 Diabetes Genetics Consortium. Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC) Clin Trials 2010;7(1 Suppl):S5-S32. Cho YH, CouperJJ, Donaghue KC Complications of childhood diabetes and the role of technology. Pediatric Endocrinol Rev. 2010 Aug;7 Suppl 3:422-31. Pearlman A, Loke J, Le Caignec C, White S, Chin L, Friedman A, Warr N, Willan J, Brauer D, Farmer C, Brooks E, Oddoux C, Riley B, Shajahan S, Camerino G, Homfray T, Crosby AH, Couper J, David A, Greenfield A, Sinclair A, Ostrer H.Region Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis development Am J Hum Genet. 2010 10;87(6):898-904. Harrington J, Pena A, Hirte C, Gent R, Couper JJ Aortic intima media thickness is a sensitive marker of atherosclerosis in children with type 1 diabetes J Pediatr 2010 156(2):237-41. Pena A, Wiltshire E, Gent R, Hirte C, Piotto L and Couper JJ Adiponectin relates to smooth muscle function and folate in obese non diabetic children. Int J Pediatr Obes 2010 Apr;5(2):185-91.

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