个人简介

2010-present Associate Professor, University of Notre Dame 2010-present Concurrent Associate Professor, Department of Physics, University of Notre Dame 2003-2010 Assistant Professor, University of Notre Dame 1994-2003 Senior Investigator, Structural Biology and Biophysics, Vertex Pharmaceuticals 1993-1994 Postdoctoral Fellow, ETH-Zürich, Switzerland 1993 Ph.D. in Molecular Biophysics, University of Michigan 1987 B.S. in Applied and Engineering Physics, Cornell University Award: 2011 Edmund P. Joyce Award for Excellence in Undergraduate Teaching 1993-1994 Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellowship 1989-1991 Molecular Biophysics Predoctoral Training Fellowship

研究领域

Biochemistry/Physical/Analytical Chemistry

Biophysics, NMR Spectroscopy, Protein and Ligand Dynamics The Peng Lab works at the interface of the physical and biological sciences to illuminate the role of bio-molecular dynamics in molecular recognition and evolution. Our main experimental tool is multi-dimensional NMR. We focus on both methods development, and applications to several proteins of therapeutic interest. Our long term interests include: (i) getting a fundamental understanding of signal transduction and protein evolution that includes conformational ensembles and dynamics. This has relevance for understanding protein-protein interaction networks and drug resistance; (ii) new methods for including flexibility information in iterative drug design. We complement our NMR studies with molecular dynamics calculations, protein biochemistry, and collaborations with groups focused on medicinal chemistry.

近期论文

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Frederick, T.E.; Wilson, B.D.; Cha, J.; Mobashery, S.; Peng, J.W. "Revealing Cell-Surface Intramolecular Interactions in the BlaR1 Protein of Methicillin-Resistant Staphylococcus aureus by NMR Spectroscopy." Biochemistry 2014, 53 (1), 10-12. Mercedes-Camacho, A.Y.; Mullins, A.B.; Mason, M.D.; Xu, Gy.G.; Mahoney, B.J.; Wang, X.S.; Peng, J.W.; Etzkorn, F.A. "Kinetic Isotope Effects Support the Twisted Amide Mechanism of Pin1 Peptidyl-Prolyl Isomerase." Biochemistry 2013, 52 (44), 7707-7713. Wilson, K.A.; Bouchard, J.J.; Peng, J.W. "Interdomain Interactions Support Interdomain Communication in Human Pin1." Biochemistry 2013, 52 (40), 6968-6981. Peng, J.W. "Exposing the Moving Parts of Proteins with NMR Spectroscopy." J. Phys. Chem. Lett. 2012, 3 (8), 1039-1051. Namanja, A.T.; Wang, XD.J.; Xu, B.L.; Mercedes-Camacho, A.Y.; Wilson, K.A.; Etzkorn, F.A; Peng, J.W. "Stereospecific gating of functional motions in Pin1." P. Natl. Acad. Sci. USA 2011, 108 (30), 12289-12294. Morcos, F.; Chatterjee, S.; McClendon, C.L.; Brenner, P.R.; Lopez-Rendon, R.; Zintsmaster, J.; Ercsey-Ravasz, M.; Sweet, C.R.; Jacobsen, M.P.; Peng, J.W.; Izaguirre, J.A. "Modeling Conformational Ensembles of Slow Functional Motions in Pin1-WW." PLOS Comput. Biol. 2010, 6 (12), e1001015.