个人简介

1996-present George and Winifred Clark Chair Professor of Chemistry, University of Notre Dame 1986-1996 Professor, University of Notre Dame 1982-1986 Associate Professor, University of Notre Dame 1977-1982 Assistant Professor, University of Notre Dame 1975-1977 Postdoctoral Research Associate, University of California, Berkeley 1976 Ph.D. in Bioorganic Chemistry, Cornell University 1971 B.S. in Chemistry, North Dakota State University Award: 2012 Outstanding Collaborator, Lilly Open Innovation Drug Discovery Program, Eli Lilly and Co. 2012 Henry L. Bolley Academic Achievement Award, North Dakota State University Alumni Award 2011 James S. Burns CSC award for Graduate Education, University of Notre Dame 2010 Elected Fellow, America Association for the Advancement of Science

研究领域

Organic Chemistry

The primary interests in Professor Miller's laboratory are in synthetic and bioorganic chemistry. Most effort is directed toward the development of new methodology and its incorporation into the syntheses and study of biologically important compounds. Special emphasis is given to asymmetrical syntheses and studies of hydroxamic acid containing microbial iron transport agents (siderophores), amino acids, peptides, b-lactam antibiotics and carbocyclic analogs of antifungal and anticancer nucleosides. The group has completed the first syntheses of the siderophores aerobactin, arthorobactin, schizokinen, several mycobactins, foroxymithine and several analogs. Recent efforts have been directed toward the syntheses and study of siderophore-antibiotic conjugates in a program designed to develop iron transport-mediated drug delivery agents, including those with potential microbe-triggered release processes. Much effort has addressed the syntheses of functionalized b-lactams, the core unit of an important class of antibiotics. The result has been the development of an efficient, and generally applicable, synthetic approach based on a biomimetic N-C4 closure. This process and subsequent chemistry has facilitated the synthesis of several novel antibiotics and b-lactamase inhibitors. The chemical versatility of the methods indicates that a variety of new b-lactams may be synthesized for studying important structure-activity relationships. Recent studies of acylnitroso cycloadditions by oxidation of hydroxamic acids have led to the development of new methods for the asymmetric syntheses of a variety of biologically interesting compounds. New chemical and enzymatic methodologies for the asymmetrical syntheses of other biologically important molecules are also being developed.

近期论文

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Teaching old dogs(Fmos-amine, azodicarboxylate, and phosphine) new tricks (triazolinones) Tet. Lett. 2013, 54, 4749. Biscatecholate-monohydroxamate mixed ligand sideropghore- carbacephalosporin conjugates are selective sideromycin antibiotics that target Acinetobacter baumannii. Wencewicz, Timothy A.; Miller, Marvin J. J. Med. Chem. 2013, 56, 4044. Thiolates Chemically Induce redox Activitation of BTZ043 and Related Potent Nitroaromatic Anti-Tuberculosis Agents. Tiwari, Rohit; Moraski, Garrett C.; Krchnak, Viktor; Miller, Patricia A.; Colon-Martinez, Mariangelli; Herrero, Eliza; Oliver, Allen, Miller, Marvin J. J. Am. Chem. Soc. 2013, 135, 3539. Trihydroxamate Siderophore-Fluoroquinolone Conjugates are Selective Sideromycin Antibiotics that Target Staphylococcus aureus. Miller, Marvin J.; Wencewicz, Timothy A.; Long, Timothy E.; Mollmann, Ute. Bioconjugate Chem, 2013, 24, 473. New and Concise Syntheses of the Bicyclic Oxamazin Core Using and Intramolecular Nitroso Diels-Alder Reaction and Ring-Closing Olefin Metathesis. Watson, Kyle D.; Carosso, Serena; Miller, Marvin J. Org. Lett. 2013, 15, 358. Chemical syntheses and in vitro antibacterial activity of two desferrioxamine B-ciproflozacin conjugates with potential esterase and phosphatase triggered drug release linkers. Ji, Cheng; Miller, Marvin, J. Bioorg. Med. Chem. 2012, 20, 3828. Expoiting bacterial iron acquisition: siderophore conjugates. Ji, Cheng; Juarez-Hernandez, Raul E.; Miller, Marvin J. Fut. Med. Chem. 2012, 4, 297. Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds. Moraski, Garrett C.; Markley, Lowell D.; Chang, Mayland; Cho, Shanhyun; Franzblau, Scott G.; Hwang, Chang Hwa; Boshoff, Helena; Miller, Marvin J. Bioorg. Med. Chem. 2012, 20, 2214. Iron transport-Mediated Drug Delivery: Practical Syntheses and In Vitro Antibacterial Studies of Tris-Catecholate Siderophore-Aminopenicillin Conjugates Reveals Selectivity Potent Antipseudomonal Activity. Ji, Cheng; Miller, Patricia A.; Miller, Marvin, J. J. Am. Chem. Soc. 2012, 134, 9898. Iron(III)-Templated Macrolactonization of Trihydroxamate Siderophores. Wencewicz, Timothy A.; Oliver, Allen G.; Miller, Marvin J. Org. Lett. 2012, 14, 4390. Syntheses and biological studies of novel spiropiperazinyl oxazolidinone antibacterial agents using spirocyclic diene derived acylnitroso Diels-Alder reaction. Ji, Cheng.; Lin, Weimin; Moraski, Garrett C.; Thanassi, Jane A.; Pucci, Michael J.; Franzblau, Scott G.; Mollmann, Ute; Miller, Marvin J. Bioorg. Med. Chem. 2012, 20, 3422. Syntheses of mycobactin analogs as potent and selective inhibitors of Mycobacterium tuberculosis. Juarez-Hernandez, Raul E.; Franzblau, Scott G.; Miller, Marvin J. Org. Biomol. Chem. 2012, 10, 7584. Syntheses of Siderophore-Drug Conjugates Using a Convergent Thiol-Maleimide System. Juarez-Hernandez, Raul E.; Miller, Patricia A.; Miller, Marvin J. ACS Med. Chem. Lett. 2012, 3, 799. Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity. Moraski, Garrett C.; Markley, Lowell D.; Hipskind, Phillip A.; Boshoff, Helena; Cho, Sangyun; Franzblau, Scott G; Miller Marvin J. ACS Med. Chem. Lett. 2011, 2, 466-470. Design, Synthesis, and Study of a Mycobactin-Artemisinin Conjugate That Has Selective and Potent Activity against Tuberculosis and Malaria. Miller, Marvin, J; Walz, Andrew J.; Zhu, Helen; Wu, Chunrui; Moraski, Garrett; Mollmann, Ute; Tristani, Esther M.; Crumbliss, Alvin L.; Ferdig, Michael T.; Checkley, Lisa; et al. J. Am. Chem. Soc. 2011, 133, 2076-2079. . Enantioselective syntheses of carbocyclic nucleoside 5'-homocarbovir, epi-4'-homocarbovir, and their cyclopropylamine analogs using facially selective Pd-mediated allylations. Tardibono, Lawrence P., Jr.; Miller, Marvin J.; Balzarini, J. Tetrahedron. 2011, 67, 825-829. N-O Chemistry for Antibiotics: New N-Alkyl-N-(pyridin-2-yl)hydroxylamine Scaffolds Generated from Nitroso Diels-Alder and Ene Chemistry. Wencewicz, Timothy A.; Yang, Baiyuan; Rudloff, James R.; Oliver, Allen G.; Miller, Marvin J. L. Med. Chem. 2011, 54, 6843-6858. One-step syntheses of nitrofuranyl benzimidazoles that are active against multidrug-resistant baterial. Moraski, Garrett C.; Thanassi, Jane A.; Podos, Steven D.; Pucci, Michael J.; Miller, Marvin J. J. Antibiotics. 2011, 64, 667-671.