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个人简介

郭灿,女。 教育经历 [1] 2003.9-2006.6 中山大学 | 肿瘤学 | 博士学位 | 博士研究生毕业 华南肿瘤学国家重点实验室 导师:曾益新院士 [2] 2000.9-2003.6 湖南师范大学 | 生物化学 | 硕士学位 | 硕士研究生毕业 蛋白质化学与发育生物学教育部重点实验室 导师:梁宋平教授 [3] 1994.9-1998.6 湖南师范大学 | 生物教育 | 学士学位 | 大学本科毕业 生命科学学院 工作经历 [1] 2006.7-至今 中南大学 | 基础医学院 | 副教授 [2] 2013.7-2014.7 Queen's University Belfast | School of Pharmacy | Academic Visitor 获国家留学基金委赞助前往Queen's University Belfast访学一年 专利成果 [1]一种环状RNA成环序列及应用 [2]检测口腔肿瘤组织中长链非编码RNA LINC00472表达量的试剂的应用 [3]长链非编码RNA LINC01420的应用方法 [4]长链非编码RNA LINC00673原位杂交探针的应用方法 [5]长链非编码RNA LINC00152的siRNA的应用及抑制制剂 [6]长链非编码RNA LOC284454的干扰制剂及其应用 科研项目 [1]TP63基因编码的新环状RNA促进鼻咽癌放疗抵抗的机制及其作为新型分子标志物的临床价值研究,国家自然科学基金委员会 [2]长链非编码RNA LINC01420作为ceRNA促进鼻咽癌侵袭转移的分子机制,国家自然科学基金 [3]NBDY促进鼻咽癌侵袭转移的分子机制研究,湖南省自然科学基金 [4]用于DNA可视化检测的量子点荧光探针的工业化制备,湖南省发改委

研究领域

[1]  肿瘤分子生物学,纳米医学。

非编码RNA参与恶性肿瘤发生发展的分子机制 恶性肿瘤的免疫逃逸机制 纳米医学

近期论文

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[1]Wang D, Zeng Z, Zhang S, Xiong F, He B, Wu Y, Li W, Tang L, Wei F, Xiang B, Li Z, Zhou Y, Zhou M.Li X, Li Y, Li G, Xiong W, Guo C*. Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell proliferation through the LOC553103-STMN1 axis:FASEB J. 2020 In press [2]Zhang L, Sun S, Wang Y, Mo Y, Xiong F, Zhang S, Zeng Z, Xiong W, Li G, Chen H*, Guo C*.Gossypol induces apoptosis of multiple myeloma cells through the JUN-JNK pathway:Am J Cancer Res. 2020 Mar 1,10(3):870-883 [3]Wang D, Tang L, Wu Y, Fan C, Zhang S, Xiang B, Zhou M, Li X, Li Y, Li G, Xiong W, Zeng Z, Guo C*.Abnormal X chromosome inactivation and tumor development:Cell Mol Life Sci. 2020 Feb 10. [4]Liang CT, Guo WH, Tan L, He YB, Xiong F, Zhang SS, Zeng ZY, Xiong W, Li GY, Guo C*.Hypoxia-inducible Factor-1: a Key Protein for Cells Adapting to Changes in Oxygen Supply:Prog Biochem Biophys. 2019 Nov,46(11):1041~1049 [5]Mo Y, Wang Y, Zhang L, Yang L, Zhou M, Li X, Li Y, Li G, Zeng Z, Xiong W, Xiong F*, Guo C*.The role of Wnt signaling pathway in tumor metabolic reprogramming:J Cancer. 2019 Jun 9,10(16):3789-3797 [6]Mo Y, Wang Y, Xiong F, Ge X, Li Z, Li X, Li Y, Li X, Xiong W, Li G, Zeng Z*, Guo C*.Proteomic Analysis of the Molecular Mechanism of Lovastatin Inhibiting the Growth of Nasopharyngeal Carcinoma Cells:J Cancer. 2019 May 26,10(10):2342-2349 [7]Wu Y, Wei F, Tang L, Liao Q, Wang H, Shi L, Gong Z, Zhang W, Zhou M, Xiang B, Wu X, Li X, Li Y, Li G.Xiong W, Zeng Z, Xiong F*, Guo C*. Herpesvirus acts with the cytoskeleton and promotes cancer progression:J Cancer. 2019 May 21,10(10):2185-2193 [8]Xiong F, Deng S, Huang HB, Li XY, Zhang WL, Liao QJ, Ma J, Li XL, Xiong W, Li GY, Zeng ZY, Guo C*.Effects and mechanisms of innate immune molecules on inhibiting nasopharyngeal carcinoma:Chin Med J (Engl). 2019 Mar 20,132(6):749-752 [9]Jiang X, Wang J, Deng X, Xiong F, Ge J, Xiang B, Wu X, Ma J, Zhou M, Li X, Li Y, Li G, Xiong W.Guo C*, Zeng Z*. Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape:Mol Cancer. 2019 Jan 15,18(1):10 [10]Jiang XJ, Wang J, Deng XY, Li XL, Li XY, Zeng ZY, Xiong W, Li GY, Xiong F*, Guo C*.Immunotherapy targeted to immune checkpoint: a revolutionary breakthrough in cancer therapy:Prog Biochem Biophys, 2018 Nov,45(11):1178-1186 [11]Tang Y, He Y, Zhang P, Wang J, Fan C, Yang L, Xiong F, Zhang S, Gong Z, Nie S, Liao Q, Li X, Li X.Li Y, Li G, Zeng Z, Xiong W*, Guo C*. LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis:Mol Cancer. 2018 Apr 4,17(1):77 [12]Wang M, Zhao J, Zhang L, Wei F, Lian Y, Wu Y, Gong Z, Zhang S, Zhou J, Cao K, Li X, Xiong W, Li G.Zeng Z*, Guo C*. Role of tumor microenvironment in tumorigenesis:J Cancer. 2017 Feb 25,8(5):761-773 [13]Yang L, Tang Y, He Y, Wang Y, Lian Y, Xiong F, Shi L, Zhang S, Gong Z, Zhou Y, Liao Q, Zhou M, Li X.Xiong W, Li Y, Li G, Zeng Z*, Guo C*. High Expression of LINC01420 indicates an unfavorable prognosis and modulates cell migration and invasion in nasopharyngeal carcinoma:J Cancer. 2017 Jan 1,8(1):97-103 [14]Guo C, Pan ZG, Li DJ, Yun JP, Zheng MZ, Hu ZY, Cheng LZ, Zeng YX.The expression of p63 is associated with the differential stage in nasopharyngeal carcinoma and EBV infection:J Transl Med. 2006 May 29,4:23

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