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个人简介

湖南省“芙蓉学者”特聘教授 中南大学基础医学院院长 国家卫健委癌变原理重点实验室主任 癌变与侵袭原理高等学校学科创新引智基地(111计划2.0) 负责人 教育部癌变与侵袭原理重点实验室副主任 “鼻咽癌的分子遗传学和基因组学研究”湖南省创新群体带头人 工作经历 2003.7-至今 中南大学肿瘤研究所 2008.8-2009.8 美国犹他大学 医学院 博士后 2005.11-2008.7 美国阿肯色医科大学 肿瘤研究所 博士后

研究领域

[1] 恶性肿瘤的免疫逃逸机制 [2] 非编码RNA参与恶性肿瘤发生发展的分子机制 [3] 鼻咽癌发病过程中EB病毒的致癌机制

[1] 恶性肿瘤的免疫逃逸机制 [2] 非编码RNA参与恶性肿瘤发生发展的分子机制 [3] 鼻咽癌发病过程中EB病毒的致癌机制

近期论文

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Wang D, Tang L, Zhang Y, Ge G, Jiang X, Mo Y, Wu P, Deng X, Li L, Zuo S, Yan Q, Zhang S, Wang F, Shi L, Li X, Xiang B, Zhou M, Liao Q, Guo C, Zeng Z, Xiong W*, Gong Z*. Regulatory pathways and drugs associated with ferroptosis in tumors.Cell Death Dis. 2022 Jun 10;13(6):544. Zhao M#, Wang Y#, Tan F, Liu L, Hou X, Fan C, Tang L, Mo Y, Wang Y, Yan Q, Gong Z, Li Z, Liao Q, Guo C, Huang H, Zeng X, Li G, Zeng Z, Xiong W*, Wang F*.Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA.Sci China Life Sci. 2022 Apr 21 Online ahead of print. PMID: 35471687 Ouyang J#, Zhong Y#, Zhang Y, Yang L, Wu P, Hou X, Xiong F, Li X, Zhang S, Gong Z, He Y, Tang Y, Zhang W, Xiang B, Zhou M, Ma J, Li Y, Li G, Zeng Z, Guo C*, Xiong W*. Long non-coding RNAs are involved in alternative splicing and promote cancer progression.Br J Cancer. 2022 May; 126(8):1113-1124. Wu P, Liu Y, Zhou R, Liu L, Zeng H, Xiong F, Zhang S, Gong Z, Zhang W, Guo C, Wang F, Zhou M, Zu X, Zeng Z, Li Y, Li G, Huang H*, Xiong W*. Extrachromosomal Circular DNA: A New Target in Cancer.Front Oncol. 2022 Apr 14; 12: 814504. Ge G, Li L, Chen M, Wu X, Yang Y, Wang D, Zuo S, Zeng Z, Xiong W*, Guo C*. Green Synthesis of Nitrogen-Doped Carbon Dots from Fresh Tea Leaves for Selective Fe3+ Ions Detection and Cellular Imaging.Nanomaterials. 2022 Mar 17; 12(6):986. Wang Y, Yan Q, Mo Y, Liu Y, Wang Y, Zhang S, Guo C, Wang F, Li G, Zeng Z, Xiong W*. Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop.Mol Cancer. 2022 Feb 28; 21(1): 62. Wang J, Ge J, Wang Y, Xiong F, Guo J, Jiang X, Zhang L, Deng X, Gong Z, Zhang S, Yan Q, He Y, Li X, Shi L, Guo C, Wang F, Li Z, Zhou M, Xiang B, Li Y, Xiong W*, Zeng Z*. EBV miRNAs BART11 and BART17-3p promote immune escape through the enhancer-mediated transcription of PD-L1.Nat Commun. 2022 Feb 14; 13(1): 866. Wang Y, Mo Y, Peng M, Zhang S, Gong Z, Yan Q, Tang Y, He Y, Liao Q, Li X, Wu X, Xiang B, Zhou M, Li Y, Li G, Li X, Zeng Z, Guo C*, Xiong W*. The influence of circular RNAs on autophagy and disease progression.Autophagy. 2022 Feb; 18(2): 240-253. Qu H, Chen M, Ge J, Zhang X, He S, Xiong F, Yan Q, Zhang S, Gong Z, Guo C, Wang F, Zeng Z, Li X, Li G, Xiong W*, Wu X*. A fluorescence strategy for circRNA quantification in tumor cells based on T7 nuclease-assisted cycling enzymatic amplification.Anal Chim Acta. 2022 Jan 2; 1189:339210. Qu H, Fan C, Chen M, Zhang X, Yan Q, Wang Y, Zhang S, Gong Z, Shi L, Li X, Liao Q, Xiang B, Zhou M, Guo C, Li G, Zeng Z, Wu X*, Xiong W*. Recent advances of fluorescent biosensors based on cyclic signal amplification technology in biomedical detection.J Nanobiotechnology. 2021 Dec 4; 19(1): 403. Ouyang J, Zhang Y, Xiong F, Zhang S, Gong Z, Yan Q, He Y, Wei F, Zhang W, Zhou M, Xiang B, Wang F, Li X, Li Y, Li G, Zeng Z, Guo C*, Xiong W*. The role of alternative splicing in human cancer progression.Am J Cancer Res. 2021 Oct 15; 11(10):4642-4667. Mo Y#, Wang Y#, Zhang S, Xiong F, Yan Q, Jiang X, Deng X, Wang Y, Fan C, Tang L, Zhang S, Gong Z, Wang F, Liao Q, Guo C, Li Y, Li X, Li G, Zeng Z*, Xiong W*. Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2.Mol Cancer. 2021 Aug 31; 20(1):112. Zhu K, Ge J, He Y, Li P, Jiang X, Wang J, Mo Y, Huang W, Gong Z, Zeng Z, Xiong W*, Yu J*. Bioinformatics Analysis of the Signaling Pathways and Genes of Gossypol Induce Death of Nasopharyngeal Carcinoma Cells.DNA Cell Biol. 2021 Aug; 40(8):1052-1063. Zhong Y, Yang L, Xiong F, He Y, Tang Y, Shi L, Fan S, Li Z, Zhang S, Gong Z, Guo C, Liao Q, Zhou Y, Zhou M, Xiang B, Li X, Li Y, Zeng Z, Li G, Xiong W*. Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc.Signal Transduct Target Ther. 2021 Jun 25; 6(1):240. Hou X, Tang L, Li X, Xiong F, Mo Y, Jiang X, Deng X, Peng M, Wu P, Zhao M, Ouyang J, Shi L, He Y, Yan Q, Zhang S, Gong Z, Li G, Zeng Z, Wang F, Guo C*, Xiong W*. Potassium Channel Protein KCNK6 Promotes Breast Cancer Cell Proliferation, Invasion, and Migration.Front Cell Dev Biol. 2021 Jun 14; 9: 616784. Li L, Xiong F, Wang Y, Zhang S, Gong Z, Li X, He Y, Shi L, Wang F, Liao Q, Xiang B, Zhou M, Li X, Li Y, Li G, Zeng Z, Xiong W*, Guo C*. What are the applications of single-cell RNA sequencing in cancer research: a systematic review.J Exp Clin Cancer Res. 2021 May 11;40(1):163. Tan F, Zhao M, Xiong F, Wang Y, Zhang S, Gong Z, Li X, He Y, Shi L, Wang F, Xiang B, Zhou M, Li X, Li Y, Li G, Zeng Z, Xiong W*, Guo C*. N6-methyladenosine-dependent signalling in cancer progression and insights into cancer therapies.J Exp Clin Cancer Res. 2021 Apr 29;40(1):146 Zhang Y, Wang D, Peng M, Tang L, Ouyang J, Xiong F, Guo C, Tang Y, Zhou Y, Liao Q, Wu X, Wang H, Yu J, Li Y, Li X, Li G, Zeng Z, Tan Y*, Xiong W*. Single-cell RNA sequencing in cancer research.J Exp Clin Cancer Res. 2021 Mar 1;40(1):81. Zhu K, Gong Z, Li P, Jiang X, Zeng Z, Xiong W*, Yu J*. A review of linc00673 as a novel lncRNA for tumor regulation.Int J Med Sci. 2021 Jan 1;18(2):398-405.[20]Fan C, Wang J, Tang Y, Zhang S, Xiong F, Guo C, Zhou Y, Li Z, Li X, Li Y, Li G, Zeng Z*, Xiong W*. Upregulation of long non-coding RNA LOC284454 may serve as a new serum diagnostic biomarker for head and neck cancers..BMC Cancer. 2020 Sep 24; 20(1): 917. Wu Y, Wang D, Wei F, Xiong F, Zhang S, Gong Z, Shi L, Li X, Xiang B, Ma J, Deng H, He Y, Liao Q, Zhang W, Li X, Li Y, Guo C, Zeng Z, Li G, Xiong W*. EBV-miR-BART12 accelerates migration and invasion in EBV-associated cancer cells by targeting tubulin polymerization- promoting protein 1.FASEB J. 2020 Dec;34(12):16205-16223. Jang X, Wang J, Deng X, Xiong F, Zhang S, Gong Z, Li X, Cao K, Deng H, He Y, Liao Q, Xiang B, Zhou M, Guo C, Zeng Z, Li G, Li X*, Xiong W*. The role of microenvironment in tumor angiogenesis.J Exp Clin Cancer Res. 2020 Sep 30; 39(1): 204. Huang W, Zhou X, Liao Q, Tang Y, Zuo L, Wang H, Chen X, Chen X, Li J, Zhu S, Deng J, Liu Y, Zhu K, Yu J*, Xiong W*. Clinicopathological and prognostic significance of PD-1/PD-L1 axis expression in patients with tongue squamous cell carcinoma.J Cell Physiol. 2020 Oct;235(10):6942-6953. Zhao J, Guo C, Xiong F, Yu J, Ge J, Wang H, Liao Q, Zhou Y, Gong Q, Xiang B, Zhou M, Li X, Li G, Xiong W*, Fang J*, Zeng Z*. Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma.Cancer Lett. 2020 May 1;477:131-143. Zeng Z, Li G, Li X, Li Y, Wu X, Guo C, Xiong F, Deng X, Zhong Y, Tang T, Peng M, Mo Y, Wu P.Wu P, Mo Y, Peng M, Tang T, Zhong Y, Deng X, Xiong F, Guo C, Wu X, Li Y, Li X, Li G, Zeng Z, Xiong W*. Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA.Mol Cancer. 2020 Feb 4; 19(1):22. Ren D, Hua Y, Yu B, Ye X, He Z, Li C, Wang J, Mo Y, Wei X, Chen Y, Zhou Y, Liao Q, Wang H, Xiang B, Zhou M, Li X, Li G, Li Y, Zeng Z, Xiong W*. Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy.Mol Cancer. 2020 Jan 30;19(1):19. Jin K, Wang S, Zhang Y, Xia M, Mo Y, Li X, Li G, Zeng Z, Xiong W*, He Y*. Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis.Cell Mol Life Sci. 2019 Nov;76(21):4275-4289. Wang W, Zhou R, Wu Y, Liu Y, Su W, Xiong W*, Zeng Z*. PVT1 Promotes Cancer Progression via MicroRNAs.Front Oncol. 2019 Jul 15;9:609. Fan CM, Wang JP, Tang YY, Zhao J, He SY, Xiong F, Guo C, Xiang B, Zhou M, Li XL, Li Y, Li GY, Xiong W*, Zeng ZY*. circMAN1A2 could serve as a novel serum biomarker for malignant tumors.Cancer Sci. 2019 Jul;110(7):2180-2188. Xia M, Zhang Y, Jin K, Lu Z, Zeng Z*, Xiong W*. Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer.Cell Biosci. 2019 Mar 19;9:27. Duan S, Guo W, Xu Z, He Y, Liang C, Mo Y, Wang Y, Xiong F, Guo C, Li Y, Li X, Li G, Zeng Z, Xiong W*, Wang F*. Natural killer group 2D receptor and its ligands in cancer immune escape.Mol Cancer. 2019 Feb 27;18(1):29. Tu C, Zeng Z, Qi P, Li X, Guo C, Xiong F, Xiang B, Zhou M, Liao Q, Yu J, Li Y, Li X, Li G*, Xiong W*. Identification of genomic alterations in nasopharyngeal carcinoma and nasopharyngeal carcinoma-derived Epstein-Barr virus by whole-genome sequencing.Carcinogenesis. 2018 Dec 31;39(12):1517-1528. Deng X, Xiong F, Li X, Xiang B, Li Z, Wu X, Guo C, Li X, Li Y, Li G, Xiong W*, Zeng Z*. Application of atomic force microscopy in cancer research.J Nanobiotechnology. 2018 Dec 11;16(1):102. Wang YA, Li XL, Mo YZ, Fan CM, Tang L, Xiong F, Guo C, Xiang B, Zhou M, Ma J, Huang X, Wu X, Li Y, Li GY, Zeng ZY*, Xiong W*. Effects of tumor metabolic microenvironment on regulatory T cells.Mol Cancer. 2018 Nov 26;17(1):168. Lian Y, Xiong F, Yang L, Bo H, Gong Z, Wang Y, Wei F, Tang Y, Li X, Liao Q, Wang H, Zhou M, Xiang B, Wu X, Li Y, Li X, Chen X, Li G, Guo C, Zeng Z*, Xiong W*. Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway.J Exp Clin Cancer Res. 2018 Oct 16;37(1):253. Fan C, Tang Y, Wang J, Xiong F, Guo C, Wang Y, Xiang B, Zhou M, Li X, Wu X, Li Y, Li X, Li G, Xiong W*, Zeng Z*. The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma.J Cancer. 2018 Jul 30;9(16):2852-2864. Zhou R, Wu Y, Wang W, Su W, Liu Y, Wang Y, Fan C, Li X, Li G, Li Y, Xiong W*, Zeng Z*. Circular RNAs (circRNAs) in cancer.Cancer Lett. 2018 Jul 1;425:134-142. Tang L, Wei F, Wu Y, He Y, Shi L, Xiong F, Gong Z, Guo C, Li X, Deng H, Cao K, Zhou M, Xiang B, Li X, Li Y, Li G, Xiong W*, Zeng Z*. Role of metabolism in cancer cell radioresistance and radiosensitization methods.J Exp Clin Cancer Res. 2018 Apr 23;37(1):87. Zhong Y, Du Y, Yang X, Mo Y, Fan C, Xiong F, Ren D, Ye X, Li C, Wang Y, Wei F, Guo C, Wu X, Li X, Li Y, Li G, Zeng Z*, Xiong W*. Circular RNAs function as ceRNAs to regulate and control human cancer progression.Mol Cancer. 2018 Apr 7;17(1):79. Tang Y, He Y, Zhang P, Wang J, Fan C, Yang L, Xiong F, Zhang S, Gong Z, Nie S, Liao Q, Li X, Li X, Li Y, Li G, Zeng Z, Xiong W*, Guo C*. LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis.Mol Cancer. 2018 Apr 4;17(1):77.

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