当前位置: X-MOL首页全球导师 国内导师 › 熊炜

个人简介

曾获荣誉: 教育部“新世纪优秀人才支持计划” 湖南省新世纪“121”人才工程第一层次人选 湖南省卫生系统学科带头人 湖南省高等学校学科带头人 中南大学基础医学院副院长 中南大学肿瘤研究所所长 国家卫健委癌变原理重点实验室主任 教育部癌变与侵袭原理重点实验室副主任 “鼻咽癌的分子遗传学和基因组学研究”湖南省创新群体带头人 教育经历 [1] 2000.9-2003.6 中南大学 | 病理学与病理生理学 | 博士学位 | 博士研究生毕业 [2] 1997.9-2000.6 湖南农业大学 | 作物遗传育种 | 硕士学位 | 硕士研究生毕业 [3] 1993.9-1997.6 湖南师范大学 | 生物教育 | 学士学位 | 大学本科毕业 工作经历 [1] 2003.7-至今 中南大学肿瘤研究所 [2] 2008.8-2009.8 美国犹他大学 | 医学院 | 博士后 [3] 2005.11-2008.7 美国阿肯色医科大学 | 肿瘤研究所 | 博士后 专利成果 [1]原位杂交检测舌癌组织中长链非编码RNA LOC284454试剂的应用 [2]长链非编码RNA LINC00472的原位杂交探针、试剂及其应用 [3]长链非编码LINC01420的siRNA的应用及抑制制剂 [4]一种卵巢癌辅助诊断或者疗效预测用的生物标记物及其应用 [5]长链非编码RNA LINC00152原位杂交探针的应用方法 [6]EB病毒编码的microRNA BART10反义寡核苷酸的应用方法 [7]EB病毒编码的microRNA BART6-3p在制备胃癌细胞抑制剂上的应用 [8]长链非编码RNA AFAP1-AS1在制备乳腺癌实时荧光定量辅助诊断制剂上的应用 [9]检测舌癌组织中长链非编码RNA LOC284454表达量的试剂的应用 [10]长链非编码RNALOC401317的表达载体、抑瘤试剂及其应用 获奖信息 [1]湖南省研究生优秀教学团队:肿瘤学基础教学团队|2019 [2]湖南省自然科学二等奖:乳铁蛋白:一个鼻咽癌遗传易感性的天然免疫分子|2019 [3]湖南省科技进步一等奖:鼻咽癌的转录组学研究|2007 [4]第六届湖南省青年科技奖|2007 [5]全国优秀博士学位论文奖:鼻咽癌遗传易感性及其易感基因的初步研究|2005 科研项目 [1]国家高技术研究发展计划(863)项目:鼻咽癌发病不同阶段生物靶点基因的筛选和鉴定 [2]国家重大基础研究(973)前期研究专项:鼻咽癌基因调控网络和多阶段发病分子模型的构建 [3]国家自然科学基金面上项目:EBV-miR-BART11促进鼻咽癌免疫逃逸的机制研究 [4]国家自然科学基金面上项目:长链非编码RNA AFAP1-AS1促进鼻咽癌侵袭转移的机制研究 [5]国家自然科学基金面上项目:FOXP1在鼻咽上皮“炎-癌”演进过程中的作用机制研究 [6]国家自然科学基金面上项目:TP53基因调控的microRNA用于鼻咽癌基因治疗和预后预测 [7]国家自然科学基金海外交流项目:microRNA与TP53基因调控网络 [8]国家自然科学基金面上项目:染色体3p21区域鼻咽癌候选易感/抑瘤基因LTF的功能研究 [9]国家自然科学基金对外交流与合作项目:肿瘤基因表达谱高级数据分析技术 [10]国家自然科学基金青年基金项目:染色体3p21区域鼻咽癌易感/抑瘤基因的研究 [11]美国多发性骨髓瘤研究基金会(Multiple Myeloma Research Foundation, MMRF)美国多发性骨髓瘤研究基金会(Multiple Myeloma Research Foundation, MMRF):Investigation of TP53-Regulated MicroRNAs and mRNAs in Multiple Myeloma [12]教育部霍英东高等院校青年教师基金 [13]湖南省重点研发计划 [14]湖南省杰出青年基金 [15]湖南省自然科学创新研究群体基金 著作成果 [1]非编码RNA与肿瘤,科学出版社,2020 [2]Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects,John Wiley & Sons, Inc,2020 [3]癌症(基础卷)[译著].副主译,科学出版社,2020 [4]现代肿瘤学基础[教材].副主编,科学出版社,2020 [5]基于WWW的生物信息学应用指南[专著].副主编,中南大学出版社,2020

研究领域

[1] 恶性肿瘤的免疫逃逸机制 [2] 非编码RNA参与恶性肿瘤发生发展的分子机制 [3] 鼻咽癌发病过程中EB病毒的致癌机制

恶性肿瘤的免疫逃逸机制 非编码RNA参与恶性肿瘤发生发展的分子机制 鼻咽癌发病过程中EB病毒的致癌机制

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

[1].Huang W, Zhou X, Liao Q, Tang Y, Zuo L, Wang H, Chen X, Chen X, Li J, Zhu S, Deng J, Liu Y, Zhu K, Yu J*, Xiong W*. Clinicopathological and prognostic significance of PD-1/PD-L1 axis expression in patients with tongue squamous cell carcinoma.:J Cell Physiol. 2020 Feb 6. doi: 10.1002/jcp.29590. Online ahead of print. [2]Zhao J, Guo C, Xiong F, Yu J, Ge J, Wang H, Liao Q, Zhou Y, Gong Q, Xiang B, Zhou M, Li X, Li G.Xiong W*, Fang J*, Zeng Z*. Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma:Cancer Lett. 2020 May 1,477:131-143 [3]Wu P, Mo Y, Peng M, Tang T, Zhong Y, Deng X, Xiong F, Guo C, Wu X, Li Y, Li X, Li G, Zeng Z.Xiong W*. Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA:Mol Cancer. 2020 Feb 4,19(1):22 [4]Ren D, Hua Y, Yu B, Ye X, He Z, Li C, Wang J, Mo Y, Wei X, Chen Y, Zhou Y, Liao Q, Wang H, Xiang B.Zhou M, Li X, Li G, Li Y, Zeng Z, Xiong W*. Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy:Mol Cancer. 2020 Jan 30,19(1):19 [5]Jin K, Wang S, Zhang Y, Xia M, Mo Y, Li X, Li G, Zeng Z, Xiong W*, He Y*.Long non-coding RNA PVT1 interacts with MYC and its downstream molecules to synergistically promote tumorigenesis:Cell Mol Life Sci. 2019 Nov,76(21):4275-4289 [6]Wang W, Zhou R, Wu Y, Liu Y, Su W, Xiong W*, Zeng Z*.PVT1 Promotes Cancer Progression via MicroRNAs:Front Oncol. 2019 Jul 15,9:609 [7]Fan CM, Wang JP, Tang YY, Zhao J, He SY, Xiong F, Guo C, Xiang B, Zhou M, Li XL, Li Y, Li GY.Xiong W*, Zeng ZY*. circMAN1A2 could serve as a novel serum biomarker for malignant tumors:Cancer Sci. 2019 Jul,110(7):2180-2188 [8]Xia M, Zhang Y, Jin K, Lu Z, Zeng Z*, Xiong W*.Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer:Cell Biosci. 2019 Mar 19,9:27 [9]Duan S, Guo W, Xu Z, He Y, Liang C, Mo Y, Wang Y, Xiong F, Guo C, Li Y, Li X, Li G, Zeng Z, Xiong W*.Wang F*. Natural killer group 2D receptor and its ligands in cancer immune escape:Mol Cancer. 2019 Feb 27,18(1):29 [10]Tu C, Zeng Z, Qi P, Li X, Guo C, Xiong F, Xiang B, Zhou M, Liao Q, Yu J, Li Y, Li X, Li G*, Xiong W*.Identification of genomic alterations in nasopharyngeal carcinoma and nasopharyngeal carcinoma-derived Epstein-Barr virus by whole-genome sequencing:Carcinogenesis. 2018 Dec 31,39(12):1517-1528 [11]Deng X, Xiong F, Li X, Xiang B, Li Z, Wu X, Guo C, Li X, Li Y, Li G, Xiong W*, Zeng Z*.Application of atomic force microscopy in cancer research:J Nanobiotechnology. 2018 Dec 11,16(1):102 [12]Wang YA, Li XL, Mo YZ, Fan CM, Tang L, Xiong F, Guo C, Xiang B, Zhou M, Ma J, Huang X, Wu X, Li Y.Li GY, Zeng ZY*, Xiong W*. Effects of tumor metabolic microenvironment on regulatory T cells:Mol Cancer. 2018 Nov 26,17(1):168 [13]Lian Y, Xiong F, Yang L, Bo H, Gong Z, Wang Y, Wei F, Tang Y, Li X, Liao Q, Wang H, Zhou M, Xiang B.Wu X, Li Y, Li X, Chen X, Li G, Guo C, Zeng Z, Xiong W* Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway:J Exp Clin Cancer Res. 2018 Oct 16,37(1):253 [14]Fan C, Tang Y, Wang J, Xiong F, Guo C, Wang Y, Xiang B, Zhou M, Li X, Wu X, Li Y, Li X, Li G.Xiong W*, Zeng Z*. The emerging role of Epstein-Barr virus encoded microRNAs in nasopharyngeal carcinoma:J Cancer. 2018 Jul 30,9(16):2852-2864 [15]Zhou R, Wu Y, Wang W, Su W, Liu Y, Wang Y, Fan C, Li X, Li G, Li Y, Xiong W*, Zeng Z*.Circular RNAs (circRNAs) in cancer:Cancer Lett. 2018 Jul 1,425:134-142 [16]Tang L, Wei F, Wu Y, He Y, Shi L, Xiong F, Gong Z, Guo C, Li X, Deng H, Cao K, Zhou M, Xiang B, Li X.Li Y, Li G, Xiong W*, Zeng Z*. Role of metabolism in cancer cell radioresistance and radiosensitization methods:J Exp Clin Cancer Res. 2018 Apr 23,37(1):87 [17]Zhong Y, Du Y, Yang X, Mo Y, Fan C, Xiong F, Ren D, Ye X, Li C, Wang Y, Wei F, Guo C, Wu X, Li X.Li Y, Li G, Zeng Z*, Xiong W*. Circular RNAs function as ceRNAs to regulate and control human cancer progression:Mol Cancer. 2018 Apr 7,17(1):79 [18]Tang Y, He Y, Zhang P, Wang J, Fan C, Yang L, Xiong F, Zhang S, Gong Z, Nie S, Liao Q, Li X, Li X.Li Y, Li G, Zeng Z, Xiong W*, Guo C*. LncRNAs regulate the cytoskeleton and related Rho/ROCK signaling in cancer metastasis:Mol Cancer. 2018 Apr 4,17(1):77 [19]Wei F, Tang L, He Y, Wu Y, Shi L, Xiong F, Gong Z, Guo C, Li X, Liao Q, Zhang W, Ni Q, Luo J, Li X.Li Y, Peng C, Chen X, Li G, Xiong W*, Zeng Z*. BPIFB1 (LPLUNC1) inhibits radioresistance in nasopharyngeal carcinoma by inhibiting VTN expression:Cell Death Dis. 2018 Apr 1,9(4):432 [20]Zhang Y, Xia M, Jin K, Wang S, Wei H, Fan C, Wu Y, Li X, Li X, Li G, Zeng Z*, Xiong W*.Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities:Mol Cancer. 2018 Feb 19,17(1):45 [21]Wei F, Wu Y, Tang L, He Y, Shi L, Xiong F, Gong Z, Guo C, Li X, Liao Q, Zhang W, Zhou M, Xiang B.Li X, Li Y, Li G, Xiong W*, Zeng Z*. BPIFB1 (LPLUNC1) inhibits migration and invasion of nasopharyngeal carcinoma by interacting with VTN and VIM:Br J Cancer. 2018 Jan,118(2):233-247 [22]Wei F, Wu Y, Tang L, Xiong F, Guo C, Li X, Zhou M, Xiang B, Li X, Li G, Xiong W*, Zeng Z*.Trend analysis of cancer incidence and mortality in China:Sci China Life Sci. 2017 Nov,60(11):1271-1275 [23]Tu C, Zeng Z, Qi P, Li X, Yu Z, Guo C, Xiong F, Xiang B, Zhou M, Gong Z, Liao Q, Yu J, He Y, Zhang W.Li X, Li Y, Li G*, Xiong W*. Genome-Wide Analysis of 18 Epstein-Barr Viruses Isolated from Primary Nasopharyngeal Carcinoma Biopsy Specimens:J Virol. 2017 Aug 10,91(17):pii: e00301-17 [24]Fan C, Tang Y, Wang J, Xiong F, Guo C, Wang Y, Zhang S, Gong Z, Wei F, Yang L, He Y, Zhou M, Li X.Li G, Xiong W*, Zeng Z*. Role of long non-coding RNAs in glucose metabolism in cancer:Mol Cancer. 2017 Jul 24,16(1):130 [25]Yu J, Liu Y, Gong Z, Zhang S, Guo C, Li X, Tang Y, Yang L, He Y, Wei F, Wang Y, Liao Q, Zhang W.Li X, Li Y, Li G, Xiong W*, Zeng Z*. Overexpression long non-coding RNA LINC00673 is associated with poor prognosis and promotes invasion and metastasis in tongue squamous cell carcinoma:Oncotarget. 2017 Mar 7,8(10):16621-16632 [26]Tang Y, Wang J, Lian Y, Fan C, Zhang P, Wu Y, Li X, Xiong F, Li X, Li G, Xiong W*, Zeng Z*.Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer:Mol Cancer. 2017 Feb 17,16(1):42 [27]Yu J, Liu Y, Guo C, Zhang S, Gong Z, Tang Y, Yang L, He Y, Lian Y, Li X, Deng H, Liao Q, Li X, Li Y.Li G, Zeng Z, Xiong W*, Yang X*. Upregulated long non-coding RNA LINC00152 expression is associated with progression and poor prognosis of tongue squamous cell carcinoma:J Cancer. 2017 Feb 11,8(4):523-530 [28]Wang Y, Mo Y, Gong Z, Yang X, Yang M, Zhang S, Xiong F, Xiang B, Zhou M, Liao Q, Zhang W, Li X, Li X.Li Y, Li G, Zeng Z*, Xiong W*. Circular RNAs in human cancer:Mol Cancer. 2017 Jan 31,16(1):25 [29]Li Q, Chen P, Zeng Z*, Liang F, Song Y, Xiong F, Li X, Gong Z, Zhou M, Xiang B, Peng C, Li X, Chen X.Li G, Xiong W*. Yeast two-hybrid screening identified WDR77 as a novel interacting partner of TSC22D2:Tumour Biol. 2016 Sep,37(9):12503-12512 [30]He B, Li W, Wu Y, Wei F, Gong Z, Bo H, Wang Y, Li X, Xiang B, Guo C, Liao Q, Chen P, Zu X, Zhou M.Ma J, Li X, Li Y, Li G, Xiong W*, Zeng Z*. Epstein-Barr virus-encoded miR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103:Cell Death Dis. 2016 Sep 1,7(9):e2353 [31]Liang F, Li Q, Li X, Li Z, Gong Z, Deng H, Xiang B, Zhou M, Li X, Li G, Zeng Z*, Xiong W*.TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer:Int J Oncol. 2016 Sep,49(3):1046-56 [32]Song Y, Li X, Zeng Z*, Li Q, Gong Z, Liao Q, Li X, Chen P, Xiang B, Zhang W, Xiong F, Zhou Y, Zhou M.Ma J, Li Y, Chen X, Li G, Xiong W*. Epstein-Barr virus encoded miR-BART11 promotes inflammation-induced carcinogenesis by targeting FOXP1:Oncotarget. 2016 Jun 14,7(24):36783-36799 [33]Xiao K, Yu Z, Li X, Li X, Tang K, Tu C, Qi P, Liao Q, Chen P, Zeng Z, Li G, Xiong W*.Genome-wide Analysis of Epstein-Barr Virus (EBV) Integration and Strain in C666-1 and Raji Cells:J Cancer. 2016 Jan 1,7(2):214-24 [34]Zeng Z, Bo H, Gong Z, Lian Y, Li X, Li X, Zhang W, Deng H, Zhou M, Peng S, Li G*, Xiong W*.AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis:Tumour Biol. 2016 Jan,37(1):729-37 [35]Zhang W, Fan S, Zou G, Shi L, Zeng Z, Ma J, Zhou Y, Li X, Zhang X, Li X, Tan M, Xiong W*, Li G*.Lactotransferrin could be a novel independent molecular prognosticator of nasopharyngeal carcinoma:Tumour Biol. 2015 Feb,36(2):675-83 [36]Gong Z, Zhang S, Zeng Z, Wu H, Yang Q, Xiong F, Shi L, Yang J, Zhang W, Zhou Y, Zeng Y, Li X.Xiang B, Peng S, Zhou M, Li X, Tan M, Li Y, Xiong W*, Li G*.LOC401317, a p53-regulated long non-coding RNA, inhibits cell proliferation and induces apoptosis in the nasopharyngeal carcinoma cell line HNE2:PLoS One. 2014 Nov 25,9(11):e110674 [37]Liao Q, Zeng Z, Guo X, Li X, Wei F, Zhang W, Li X, Chen P, Liang F, Xiang B, Ma J, Wu M, Tang H.Deng M, Zeng X, Tang K, Xiong W*, Li G*. LPLUNC1 suppresses IL-6-induced nasopharyngeal carcinoma cell proliferation via inhibiting the Stat3 activation:Oncogene. 2014 Apr 17,33(16):2098-109 [38]Zeng Z, Huang H, Huang L, Sun M, Yan Q, Song Y, Wei F, Bo H, Gong Z, Zeng Y, Li Q, Zhang W, Li X.Xiang B, Li X, Li Y, Xiong W*, Li G*. Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas:Sci China Life Sci. 2014 Mar,57(3):315-326 [39]Zhang W, Zeng Z, Fan S, Wang J, Yang J, Zhou Y, Li X, Huang D, Liang F, Wu M, Tang K, Cao L, Li X.Xiong W*, Li G*. Evaluation of the prognostic value of TGF-β superfamily type I receptor and TGF-β type II receptor expression in nasopharyngeal carcinoma using high-throughput tissue microarrays:J Mol Histol. 2012 Jun,43(3):297-306 [40]Zeng Z, Huang H, Zhang W, Xiang B, Zhou M, Zhou Y, Ma J, Yi M, Li X, Li X, Xiong W*, Li G*.Nasopharyngeal carcinoma: advances in genomics and molecular genetics:Sci China Life Sci. 2011 Oct,54(10):966-75 [41]Xiong W, Wu X, Starnes S, Johnson SK, Haessler J, Wang S, Chen L, Barlogie B, Shaughnessy JD Jr.Zhan F. An analysis of the clinical and biologic significance of TP53 loss and the identification of potential novel transcriptional targets of TP53 in multiple myeloma:Blood. 2008 Nov 15,112(10):4235-46 [42]Zeng Z, Zhou Y, Zhang W, Li X, Xiong W*, Liu H, Fan S, Qian J, Wang L, Li Z, Shen S, Li G*.Family-based association analysis validates chromosome 3p21 as a putative nasopharyngeal carcinoma susceptibility locus:Genet Med. 2006 Mar,8(3):156-60 [43]Xiong W, Zeng ZY, Xia JH, Xia K, Shen SR, Li XL, Hu DX, Tan C, Xiang JJ, Zhou J, Deng H, Fan SQ.Li WF, Wang R, Zhou M, Zhu SG, Lü HB, Qian J, Zhang BC, Wang JR, Ma J, Xiao BY, Huang H, Zhang QH, Zhou YH, Luo XM, Zhou HD, Yang YX, Dai HP, Feng GY, Pan Q, Wu LQ, He L, Li GY*. A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma:Cancer Res. 2004 Mar 15,64(6):1972-4

学术兼职

[1] 湖南省病理生理学会副理事长 [2] 湖南省抗癌协会副理事长

推荐链接
down
wechat
bug