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曾获荣誉: 中南大学基础医学院优秀共产党员(2006/2007年) 中南大学基础医学院优秀教师(连续5年) 湖南省优秀青年骨干教师(2007) 司法部全国司法鉴定先进个人(2009/2010) 蔡继峰 教授,医学博士、临床心理学博士后,法医学教授,博士生导师、主任法医师,湖南省法医学学科带头人,湖南省湘雅司法鉴定中心主任,湖南省司法鉴定协会会长,法医病理专业委员会主任委员,司法部实验室及检验机构资格认证国家级评审员,教育部法医学高等教育教学指导委员会委员,卫健委中华医学会及湖南省医学会医疗事故技术鉴定专家库成员,科技部科技重点研发计划会评专家,国家自然科学基金委优秀青年基金会评专家,国家自然科学奖励评审专家。 主持国家自然科学基金重点项目子课题1项,国家自然科学基金面上项目4项,湖南省自然科学基金重点项目1项,其他省部级科研项目3项。近年在Int J Leg Med、Forensic Sci Int Genet.等专业杂志发表SCI学术论文40余篇,授权发明专利2项,实用新型专利8项;法医学教材《法医昆虫学》主编,法医学“十三五”规划教材《法医人类学》副主编,主编其他法医学专著6部,主持国外法医学译著两部。 教育经历 [1] 2005.9-2010.7 中南大学 | 临床心理学 | 博士后 [2] 2002.9-2005.7 四川大学 | 法医学 | 博士学位 | 博士研究生毕业 [3] 2000.9-2002.7 四川大学 | 法医学 | 硕士学位 | 硕士研究生毕业 [4] 1988.9-1993.7 内蒙古医学院 | 临床医学 | 学士学位 | 大学本科毕业 工作经历 [1] 2005.9-至今 湖南省湘雅司法司法鉴定中心 | 主任 | 湖南省湘雅司法司法鉴定中心机构负责人 [2] 2005.7-2019.1 中南大学基础医学院 | 法医学 | 副院长 | 中南大学基础医学院 [3] 1993.7-2002.9 内蒙古自治区人民检察院 | 技术处 | 检察官 | 检察官 科研项目 [1]人工智能系统解析疑难生物物证法医精准鉴识探索研究,自然科学基金委 [2]法医学人体生物样本库 [3]湖南省社会发展领域重点研发项目 [4]尸源性VOCs影响丝光绿蝇定位尸体机制的法医学研究,国家自然科学基金委 [5]利用SSOs演替进行PMI推断的法医学研究,国家自然科学基金委 [6]探索长沙地区常见嗜尸性麻蝇的发育规律,2012国家大学生创新训练立项资助项目 [7]Pre-CI期尸体腐败微生物群落演替与PMI推断,2012年度上海市法医学重点实验室开放课题 [8]湖南地区常见嗜尸性麻蝇分子标记检测及嗜尸特性观察,湖南省自然科学基金一般项目 [9]嗜尸性昆虫mtDNA几种提取方法的探索,2011年大学生创新训练立项资助项目 [10]长沙地区嗜尸性甲虫(鞘翅目)mtDNA分子鉴定,中南大学研究生教育创新工程项目 [11]玻璃体液化学变化推断死亡时间及测定仪器的关键技术研究,中南大学大学生创新性实验计划,苏日娜 [12]长沙地区嗜尸性麻蝇分子标记法医学研究,中南大学大学生创新性实验计划,汤振楚 [13]从嗜尸性蝇蛆嗉囊内容物提取人类DNA技术在法医案件中的应用研究,中南大学大学生创新性实验计划,李响 [14]法医尸体解剖教学范例数字化视频的研发,中南大学研究生教育创新工程项目 [15]fMRI对说谎功能定位的研究,湖南省科技计划项目基金 [16]fMRI对说谎功能定位的研究,中国博士后科学基金 [17]长沙地区嗜尸性苍蝇群落演替及mtDNA分子标记法医学研究,7年制姚跃2006年中南大学大学生创新教育项目基金 [18]玻璃体液化学变化推断死亡时间的研究,2005年中南大学科研启动基金,蔡继峰 [19]嗜尸性昆虫mtDNA分子标记检测及地区基因库建立,2006年国家自然科学基金 著作成果 [1]《法医人类学》[教材],人民卫生出版社,2020 [2]《法医昆虫学》[教材],人民卫生出版社,2020 [3]《爆炸与冲击相关损伤》(译著)[译著],北京-人民卫生出版社,2020 [4]《血痕形态证据--取证与分析》(译著)[译著],北京-人民卫生出版社,2020 [5]《医疗损害鉴定与防范新进展》[专著].主编:蔡继峰 郭亚东 副主编:常云峰 张长全 闫文广 丁宗烽,人民卫生出版社,2020 [6]《现代法医昆虫学》[教材].蔡继峰 郭亚东 孟凡明,北京-人民卫生出版社,2020 [7]《医疗损害的预防与处理》[专著].主 编:蔡继峰 副主编:常林 夏文涛 成建定 李江涛,人民卫生出版社,2020 [8]《医疗损害防范手册》[专著].主 编:蔡继峰 孟兴凯,人民卫生出版社,2020 [9]《基层医疗机构医疗损害防范知识及案例解析》[专著],人民卫生出版社,2020 [10]《医疗损害司法鉴定实务及防范措施》[编著],人民卫生出版社,2020 [11]《实用法医学》(第十编-第七章 )[编著],科学出版社,2020 [12]《法医学》(第十三章,第十六章)[教材],江 苏 科 学 技 术 出 版 社,2020 [13]《法医学》(第十一章)[教材],人民卫生出版社,2020 [14]《法医病理司法鉴定实务》( 第十九章)[编著],中华人民共和国司法部司法鉴定管理局.法律出版社,2020 [15]《法医学辞典》(法医昆虫学部分)[辞典、字典],化学工业出版社,2020 专利成果 [1]一种用于毒物检测的脊髓取样器,丁艳君 ; 蔡继峰 ; 郭亚东 ; 扎拉嘎白乙拉 ; 闫杰 [2]一种法医用毒物勘察工具箱,丁艳君 ; 蔡继峰 ; 郭亚东 ; 扎拉嘎白乙拉 ; 闫杰 [3]银纳米簇检测玻璃体液中钾离子浓度推断死亡时间的方法,丁艳君 ; 凌江 ; 李杏梅 ; 蔡继峰 ; 郭亚东 ; 扎拉嘎白乙拉 [4]用于液体钙离子检测的玻片或试纸阵列及制备和使用方法,丁艳君 ; 凌江 ; 蔡继峰 ; 郭亚东 ; 扎拉嘎白乙拉 [5]一种聚丙烯酰胺凝胶电泳用多功能装置,郭娟娟,蔡继峰 [6]一种亲子鉴定用电动采样装置,扎拉嘎白乙拉 郭亚东 蔡继峰 [7]一种脑组织取材辅助装置,郭亚东 闫杰 蔡继峰 [8]一种法医解剖用延髓剪,闫杰 扎拉嘎白乙拉 蔡继峰 [9]法医昆虫演替实验样本及数据自动采集设备,闫杰,符晓亮,蔡继峰 教学成果 [1]中南大学高等教育教学成果奖,2012-10-01 获奖信息 [1]中南大学比亚迪教师奖励金|2012

研究领域

[1] 法医微生物学 [2] 法医昆虫学 [3] 法医病理学

1.BACTERIAL COMMUNITY SUCCESSION AND POSTMORTEM INTERVAL(PMI) The estimation of postmortem interval (PMI) is one of the most difficult tasks in forensic practice, especially in putrefied bodies. After death, organisms are decomposed by a variety of enzymes and microorganisms. To investigate the succession of bacterial community in the decomposition process, rat remains were placed outside to decompose under natural conditions in Changsha city, China. Bacterial communities from two regions (buccal cavity and rectum) were sampled when experiment animals were alive, soon after they died and at various time span after death. Bacterial samples were analyzed by high throughput metagenomic sequencing of 16S rRNA gene conducted on an Illumina MiSeq platform. Our data showed that several bacteria genera were potentially useful for estimating the PMI, such as Streptococcus, Ignatzschineria, Acinetobacter, Aggregatibacter, Prevotella and Proteus. There were significant bacterial community structure differences in taxon richness and relative abundance patterns through the decomposition process and across different body sites. As decomposition progressed, a negative linear relationship for taxon richness was found along with a shift from aerobic bacteria to anaerobic bacteria. We first reported the bacterial biodiversity in the decomposition process in Chinese terrestrial scenarios and climatic conditions. Bacteria have a remarkable potential for estimate the PMI and next generation sequencing is a novel method to support the application of bacteria in forensic science. Figure 1 Bacterial community structure in buccal cavity at the genus level. Only the top ten genera are listed. Figure 2 Bacterial community structure in rectum at the genus level. Only the top ten genera are listed. 2.THE POTENTIAL USE OF FUNGI COMMUNITY IN POSTMORTEM INTERVAL ESTIMATION IN CHINA Estimation of postmortem interval (PMI) with fair accuracy is a critical step in death investigations. Although many approaches are available to estimate PMI through physical findings and biochemical tests, accurate PMI calculation by these conventional methods is still difficult because it is readily affected by surrounding conditions, such as ambient temperature and humidity. It is reported that body provides a residence for diverse commensal microbiota. Microorganisms such as fungi have major roles in this microbial community stability and post- putrefaction fungi have been recorded several times in association with decomposed mammalian cadavers in disparate regions. The succession and diversity of these fungi are reviewed with a view to their potential as a forensic tool. The research of mycology is an interface to forensic investigation and may provide a means to estimate PMI within serious decomposition. To evaluate the use of succession and diversity of fungi species for PMI estimation, we investigated the Internal Transcribed Spacer (ITS) of fungi community on 3 points of time of rat carcasses conducted by Illumina MiSeq platform. Through high-throughput sequencing, several fungi genus such as Mrakia and Amorphotheca are found in community succession (Fig. 1) and the community structure of each sample significantly differs in overall taxon richness and relative abundance patterns within decomposition progress (Fig. 2). The succession and diversity of fungi community in corpse decomposition revealed by the indicator of ITS would be a potential forensic tool for PMI estimation.

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[1].Evaluation of Reference Genes and Age Estimation of Forensically Useful Aldrichina grahami (Diptera: Calliphoridae) During Intrapuparial Period:Journal of Medical Entomology,2020 [2].Identi?cation of olfactory genes of a forensically important blow ?y, Aldrichina grahami (Diptera: Calliphoridae).:PeerJ,2020 [3].A smartphone-based bacteria sensor for rapid and portable identification of forensic saliva sample:Sensors & Actuators: B. Chemical,2020,2020(320) [4].Chromosome-level genome assembly of Aldrichina grahami, a forensically important blowfly.[J]:Giga Science,2020 [5].Dynamic transcriptome profiling exploring cold tolerance in forensically important blow fly, Aldrichina grahami (Diptera: Calliphoridae):BMC Genomics,2020,21(92) [6]Xingmei Li, Yanjun Ding, Jiang Ling ,Wenyan Yao, Lagabaiyla Zha, Na Li, Yunfeng Chang, Yong Wang, J.Bacteria-targeting BSA-stabilized SiC nanoparticles as a fluorescent nanoprobe for forensic identification of saliva [J].[J]:Microchimica Acta (2019) 186:756. [7]Jing He, Juanjuan Guo, Xiaoliang Fu, Jifeng Cai.Potential use of high-throughput sequencing of bacterial communities for postmortem submersion interval estimation [J].[J]:Brazilian Journal of Microbiology, 2019; 50(4): 99 [8]Xiaoliang fu, Juanjuan Guo, Dmitrijs finkelbergs, Jing He, Lagabaiyila Zha, Yadong Guo, Jifeng cai.fungal succession during mammalian cadaver decomposition and potential forensic implications. Sci Rep, Article?number:?12907?(2019). 2019, 9(1):1-9.[J],2019 [9]Yanjun Ding, Xingmei Li, Yadong Guo, Weicheng Duan, Jiang Ling, Lagabaiyla Zha, Jie Yan, Ying Zou,Ji.Estimation of postmortem interval by vitreous potassium evaluation with a novel fluorescence aptasensor [J]. Sci Rep, 2017, 7:9.[J],2017 [10]Juanjuan Guo,Xiaoliang Fu, Huidan Liao, Zhenyu Hu, Lingling Long, Weitao Yan, Yanjun Ding, Lagabaiyi.Potential use of bacterial community succession for estimating post-mortem interval as revealed by high-throughput sequencing [J]. Sci Rep, 2016, 6:11.[J] [11]Jie Yan, Huidan Liao, Kai Xie,Jifeng cai.The complete mitochondria genome of Chrysomya pinguis (Diptera:Calliphoridae).[J]:Mitochondrial DNA Part A,2016 [12]Jie Yan, Huidan Liao, Zhenyu Zhu, Kai Xie, Yadong Guo,Jifeng cai.The complete mitochondria genome of Parasarcophaga similis (Diptera: Sarcophagidae).[J]:Mitochondrial DNA, Early Online: 1-2,2014.,2016 [13]Juanjuan Guo, Xiaoliang Fu, Huidan Liao, Zhenyu Hu, Lingling Long, Weitao Yan, Yanjun Ding, Lagabaiy.Potential use of bacterial community succession for estimating postmortem interval as revealed by high-throughput sequencing.[J]:Scientific Reports [14]Huidan Liao, Xiang Yang, Zhilong Li, Yanjun Ding, Yadong Guo.The complete mitochondria genome of Parasarcophaga albiceps (Diptera: Sarcophagidae).[J]:Mitochondrial DNA [15]Liu QL, Cai JF, Chang YF, Gu Y, Guo YD, Wang XH, Weng JF, Zhong M, Wang X, Yang L, Wu KL, Lan LM, Wa.Identi?cation of forensically important blow ?y species (Diptera: Calliphoridae) in China by mitochondrial cytochrome oxidase I gene differentiation.[J]:Insect Science [16]Kun Xiong, Jufang Huang, Huidan Liao, Lingling Long, Yanjun Ding, Jie Yan, Jifeng Cai.Necroptosis, a Novel Form of Cell Death, Contributes to Neuronal Damage in a Methamphetamie Injury Model.[J]:Toxicology in Vitro [17]Juanjuan Guo, Huidan Liao, Xiaoliang Fu, Lagabaiyila Zha, Jinshan Liu, Jifeng Cai.Bacterial community succession analysis by next generation sequencing in Changsha city, China.[J]:Forensic Science International: Genetics Supplemen [18]Xiaoliang Fu, Juanjuan Guo, Zhenyu Zhu, Zhiyu Ding, Lagabaiyila Zha, Jifeng Cai.The potential use of fungi community in postmortem interval estimation in China.[J]:Forensic Science International: Genetics Supplemen [19]Cai JF, Gu Y, Yao SQ.Screening for Personality Disorders Among Chinese Prison Inmates.[J]:PSYCHIATRIC SERVICES [20]Liu QL, Cai JF, Guo YD, Wang XH, Gu Y, Yi WP.Letter to Editor, identification of forensically significant calliphorids based on mitochondrial DNA cytochrome oxidase I (COI) gene in China.[J]:Forensic Science International [21]Wang XH, Cai JF, Guo YD, Chang YF, Wu KL, Liu QL, Wang JF, Yang L, Lan LM, Zhong M, Wang X, Cheng YS.The availability of 16SrDNA gene for identifying forensically important blowflies in China.[J]:Romanian Journal of Legal Medicine [22]Ji feng Cai, Ling Mei Lan, Ren Li Deng.Population Genetics of Two STR Loci D2S1332 and D2S1356 in a Chinese Han Population in Hohhot.[J]:J Forensic Sci [23]Cai JF, Wen JF, Chang YF, Meng FM, GuoYD, Yang L, Liang L.Identiication of forensically signiicant beetles (Coleoptera: Staphylinoidae) based on COI gene in China.[J]:Romania Journal of Legal Medicine [24]Guo YD, Xie D, Yan J, Cai JF, Yin G, Wu LX.Primary pulmonary rhabdomyosarcoma with brain metastases in a child: a case report with medico legal implications.[J]:Journal of forensic and legal medicine [25]Xiaoliang Fu, Juanjuan Guo, Zhenyu Zhu, Zhiyu Ding, Lagabaiyila Zha, Jifeng Cai.The potential use of fungi community in postmortem interval estimation in China:Forensic Science International: Genetics Supplemen [26]Juanjuan Guo, Ying Liu, Yulong Peng, Yong Fu, Libing Yun, Zhiyu Ding, Zhenyu Hu, Yang Chen, Jifeng C.Genetic polymorphism of 21 non-CODIS STR loci for Han population in Hunan Province, China.[J]:Forensic Science International: Genetics [27]Zhuang Q, Cai JF, Zhang MQ, Feng H, GuoYD, Lan LM, Chen YQ. Molecular identiication of forensically.Molecular identiication of forensically signiicant beetles (Coleoptera) in China based on COI gene.[J]:Revista Colombiana de Entomología [28]Li X, Cai JF, Guo YD, Xiong F, Zhang L, Feng H, Meng FM, Fu Y, Li JB, Chen YQ.Mitochondrial DNA and STR analyses for human DNA from maggots crop contents: A forensic entomology case from central-southern China.[J]:Tropical Biomedicine [29]Xiong F, Guo YD, Luo BH, Zhang L, Cai JF, Li XL, Yang Z.Identification of the forensically important flies (Diptera: Muscidae) based on cytochrome oxidase subunit Ⅰ(COⅠ) gene in China.[J]:African journal of Biotechnology [30]Jie Yan, Huidan Liao, Kai Xie,Jifeng Cai.The complete mitochondria genome of Chrysomya pinguis (Diptera:Calliphoridae).[J]:Mitochondrial DNA [31]Juanjuan Guo, Xiaoliang Fu, Huidan Liao, Zhenyu Hu, Lingling Long, Weitao Yan, Yanjun Ding, Lagabaiy.Potential use of bacterial community succession for estimating postmortem interval as revealed by high-throughput sequencing.[J]:Scientific Reports [32]Guo YD, Cai JF, Tang ZC, Xiong F, Zhang L, Fu Y, Li JB, Chen YQ, Meng FM, Wen JF.Application of Aldrichina grahami (Diptera, Calliphoridae) for forensic investigation in central-south China.[J]:Romania Journal of Legal Medicine [33]Juanjuan Guo, Ying Liu, Yulong Peng, Yong Fu, Libing Yun, Zhiyu Ding, Zhenyu Hu, Yang Chen, Jifeng.Genetic polymorphism of 21 non-CODIS STR loci for Han population in Hunan Province, China.[J]:Forensic Science International: Genetics [34]闫杰,苏丽娜,廖慧丹,郭亚东,张长全,扎拉嘎白乙拉,蔡继峰.机会丧失理论在医疗纠纷处置中的应用.[J]:中国司法鉴定 [35]蒋莹, 蔡继峰, 杨玲, 易文平, 兰玲梅, 李响, 李剑波.湖南省永州地区夏秋季常见嗜尸性昆虫及螺类的研究.[J]:应用昆虫学报 [36]陈瑶清, 郭亚东, 李茂枝, 熊 枫, 李剑波, 蔡继峰..常见嗜尸性昆虫mtDNA 提取方法的比较.[J]:法医学杂志 [37]王翔, 蔡继峰, 钟鸣, 李剑波, 张金国, 兰玲梅.运用有机酚-氯仿法结合磁珠法提取蝇蛆体内人类DNA的研究.法医学杂志.[J] [38]李进华, 蔡继峰, 郭亚东, 陈凤磊, 陈瑶清.利用COI 序列序列鉴定常见嗜尸性蝇种.[J]:中国法医学杂志 [39]谢丹,彭钰龙,郭亚东,蔡继峰.法医昆虫学PMI的推断与Daubert规则之思考.[J]:法医学杂志 [40]郭亚东, 蔡继峰, 苏日娜, 常云峰, 兰玲梅, 文继舫.常见嗜尸性甲虫及蝇类虫体不同部位mtDNA提取效果的比较:法医学杂志 [41]Guo YD, Cai JF, Wang XH, Lan LM, Liu QL, Li X, Chang YF, Zhong M, Wang X, Wen JF.Identification of forensically important sarcophagid flies (Diptera: Sarcophagidae) based on COI gene in China.[J]:Romanian Journal of Legal Medicine [42]Guo YD, Cai JF, Xiong F, Wang HJ, Wen JF, Li JB, Chen YQ..The utility of Mitochondrial DNA fragments for genetic identification of forensically important sarcophagid flies (Diptera: Sarcophagidae) in China.[J]:Tropical Biomedicine [43]GuoYD, Cai JF, Meng FM, Chang YF, Gu Y, Lan LM, Liang L, Wen JF..Identification of forensically important flesh flies based on a shorter fragment of the cytochrome oxidase subunit I gene in China.[J]:Medical and Veterinary Entomology [44]郭娟娟,邹鹰,李情鹏,左道宏,刘金山,郭亚东,闫杰,扎拉嘎白乙拉,蔡继峰,兰玲梅.湖南汉族人群21个STR基因座的遗传多态性研究.[J]:法医学杂志 [45]杨玲, 蔡继峰, 兰玲梅, 蒋 莹, 李 响, 李剑波, 戴朝辉, 彭新.石家庄地区夏秋季常见嗜尸性昆虫演替.[J]:法医学杂志 [46]Li X, Cai JF, Guo, YD, Wu KL, Wang JF, Liu QL, Wang XH, Chang YF, Yang L, Lan LM, Zhong M, Wang X.The availability of 16S rRNA for the identification of forensically 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学术兼职

[1] 法医学高等教育教学指导委员会委员 [2] 湖南省法医专业委员会主任委员 [3] 中国免疫学会会员 [4] 中国法医学会会员 [5] 中华医学会医疗事故技术鉴定专家 [6] 国家及省级实验室、检查机构资质认证、认可评审员 [7] 湖南省司法鉴定人协会会长 [8] 湖南省医疗事故技术鉴定专家

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