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个人简介

曾获荣誉: 2017-12-31 当选: 中南大学西南铝教育奖 2017-08-01 当选: 中国青年解剖学家 黄河,医学博士,博士后,组织学与胚胎学、医学发育生物学教授,博士生导师,现任中南大学基础医学院副院长。2009年至2011年曾在美国麻省大学医学院从事博士后研究。主持4项国家自然科学基金等省部级以上项目12项。在J Biol Chem、Oncogene、Int J Cardiol、Biochim Biophys Acta、Elife、Autophagy、Theranostics 等杂志发表第一或通讯作者SCI论文19篇,H指数23。 教育经历 [1] 2003.9-2005.12 中南大学湘雅医学院 | 病理学与病理生理学肿瘤学专业 | 博士学位 | 博士研究生毕业 [2] 1998.9-2001.6 中南大学湘雅医学院 | 人体解剖与组织胚胎学 | 硕士学位 [3] 1992.9-1996.6 湖南师范大学 | 生物学 | 学士学位 | 大学本科毕业 工作经历 [1] 2017.9-至今 中南大学 | 基础医学院 | 教授 | 全职 [2] 2017.8-2019.2 新疆医科大学 | 科学技术处 | 副处长 | 教授 | 中组部第九批援疆干部 [3] 2015.11-2017.7 新疆医科大学 | 科学技术处 | 副处长 | 副教授 | 中组部第八批援疆干部 [4] 2009.7-2011.7 美国麻省大学 | 医学院癌症生物学系 | 博士后 | 全职 [5] 2007.9-2017.9 中南大学 | 基础医学院组织胚胎学系 | 系副主任、支部书记 | 副教授 | 全职 期间赴美留学、作为第八批援疆干部任新疆医科大学科技处副处长 [6] 2006.3-2009.3 中南大学 | 基础医学院人体解剖与神经生物学系 | 博士后 | 在职 [7] 2001.9-2007.9 中南大学 | 基础医学院组织胚胎学系 | 工会小组长、教学秘书、教研室副主任、支部书记 | 讲师 | 全职 [8] 1996.7-2001.9 湖南医科大学 | 基础医学院组织胚胎学系 | 工会小组长、实验总负责 | 助教 | 全职 [9] 2017.9-2019.5 中南大学 | 组织学与胚胎学系 | 教授 | 全职 科研项目 [1]湖南省自然基金面上项目:SuFu在肠道发育与肿瘤形成中的分子机制,在研,湖南省科技厅,黄河 [2]国家自然科学基金项目:一种新型靶向肿瘤(干)细胞纳米载体的构建、生物效应评估及光动力治疗的分子机制,在研,国家自然基金委员会,黄河 [3]国家自然科学基金面上项目:Smad7在肠道发育与肿瘤形成中的分子机制,已结题,国家自然基金委员会,黄河 [4]国家自然科学基金专项基金项目:LRRC4 在脊髓损伤与修复中的作用及机制,已结题,国家自然科学基金委员会,黄河 [5]国家自然科学基金青年基金项目:脑组织特异性新基因LRRC4的转录调控机制研究,已结题,国家自然基金委员会,黄河 [6]中国博士后基金:一个新基因的转录调控机制研究,已结题,第三十九批中国博士后科学基金,黄河 教学成果 [1]全程应用计算机技术开展组织胚胎学教学与规范化管理的研究 [2]现代教育技术在组织胚胎学教学与管理中的模式与实践,2002-12-31

研究领域

[1] 人体解剖与组织胚胎学 [2] 发育生物学 [3] 消化系统发育与肿瘤形成 [4] 肿瘤分子靶向治疗

近期论文

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[1].Zhengjun Lin, Shiyao Lu, Xubin Xie, Xuyang Yi, He Huang. Noncoding RNAs in drug-resistant pancreatic cancer: A review. Biomedicine & Pharmacotherapy, 2020, 131, 110768. (SCI, JCR2, IF: 4.545) [2].Qingxin Zhou#, Meihua Lin#, Xing Feng#, Fei Ma#, Yuekun Zhu, Xing Liu, Chao Qu, Hong Sui, Bei Sun, Anlong Zhu, Heng Zhang, He Huang, Zhi Gao, Yongxiang Zhao, Jiangyun Sun, Yuxian Bai, Junfei Jin*, Xuehui Hong*, Chang Zou*, Zhiyong Zhang*. Targeting CLK3 Inhibits the Progression of Cholangiocarcinoma by Reprogramming Nucleotide Metabolism. J Exp Med, 2020, 217(8):e20191779. (SCI, JCR1, Nature Index, IF: 10.892) [3].Heng Zhang, He Huang*, Xing Feng, Huiwen Song, Zhiyong Zhang*, Aizong Shen*, Xingfeng Qiu*. Deubiquitinase USP28 inhibits ubiquitin ligase KLHL2-mediated uridine-cytidine kinase 1 degradation and confers sensitivity to 5'-azacytidine-resistant human leukemia cells. Theranostics, 2020, 10(3):1046-1059. (SCI, JCR1, IF: 8.063) [4].Chaochao Tan#, Yunfeng Li#, Xiahe Huang, Meijin Wei, Ying Huang, Zhouqin Tang, He Huang, Wen Zhou, Yingchun Wang, Jiliang Hu*. Extensive protein S-nitrosylation associated with human pancreatic ductal adenocarcinoma pathogenesis. Cell Death Dis, 2019, 10(12): 914. (SCI, JCR2, IF: 5.959) [5].Yuyu Zhang, Chengbin Zhang, Qin Zhao, Wei Wei, Zhuo Dong, Lihong Shao, Jianbo Li, Wei Wu, Heng Zhang, He Huang, Feng Liu,* Shunzi Jin*. MiR-873/NDFIP1 axis promotes hepatocellular carcinoma growth and metastasis through AKT/mTOR-mediated Warburg effect. Am J Cancer Res, 2019, 9(5):927-944. ISSN:2156-6976 (SCI,JCR2, IF:3.998) [6].Huiwen Song#, Xing Feng#, Heng Zhang#, Yunmei Luo, Juan Huang, Meihua Lin, Junfei Jin, Xue Ding, Shujing Wu, He Huang, Tian Yu, Mukun Zhang, Haiou Hong, Shihua Yao*, Yongxiang Zhao*, Zhiyong Zhang*. METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes. Autophagy, 2019, 15(8):1419-1437. (SCI, JCR1, IF: 11.059),2019 [7].Xing Feng#, Yanyan Jia#, Yuyu Zhang#, Fei Ma#, Yuekun Zhu, Xuehui Hong, Qingxin Zhou, Ruixing He, Heng Zhang, Junfei Jin, Daxun Piao, He Huang*, Qinghua Li*, Xingfeng Qiu*, Zhiyong Zhang*. Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth. Autophagy, 2019, 15(7):1130-1149. (*Corresponding Author, SCI, JCR1, IF: 11.059) [8].Wei Zeng, Jinfeng Zhu, Junyuan Liu?, Yinglong Li?, Xiang Dong?, He Huang*, Li Shan*. miR-133b inhibits cell proliferation, migration and invasion of esophageal squamous cell carcinoma by targeting EGFR. Biomedicine & Pharmacotherapy, 2019, 111:476-484. (*Corresponding Author, SCI, JCR3, IF: 3.457) [9].Jinfeng Zhu, Yi Liu, He Huang, Li Shan, Zhigang Han, Junyuan Liu, Yinglong Li, Xiang Dong, Wei Zeng*. MicroRNA-133b/EGFR axis regulates esophageal squamous cell carcinoma metastases by suppressing anoikis resistance and anchorage-independent growth. Cancer Cell Int, 2018, 18:193. (SCI, JCR3, IF: 3.960) [10].Qiong Duan, Lu Xiong, Chaonan Liao, Zhenzhen Liu, Yi Xiao, Ruixue Huang, Ting Tan, Yanhao Ouyang, Jinxing Cai, Meifang Xiao, Huilan Xu, Zihua Chen, Lizhang Chen*, Tianlun Yang*, He Huang*. Population based and animal study on the effects of Schistosoma japonicum infection in the regulation of host glucose homeostasis. Acta Tropica, 2018, 180: 33-41. (*Corresponding Author, SCI, JCR2, IF: 2.218) [11].Guoqing Ouyang#, Li Xiong#, Zhipeng Liu, Brandon Lam, Brian Bui, Lun Ma, Xiang Chen, Pan Zhou, Kunpeng Wang, Zijian Zhang, He Huang, Xiongying Miao, Wei Chen*, Yu Wen*. Inhibition of autophagy potentiates the apoptosis-inducing effects of photodynamic therapy on human colon cancer cells. Photodiagnosis Photodyn Ther, 2018, 21: 396-403.[J] [12].Xuehui Hong#, He Huang#, Xingfeng Qiu, Zhijie Ding, Xing Feng, Yuekun Zhu, Huiqin Zhuo, Jingjing Hou, Jiabao Zhao, Wangyu Cai, Ruihua Sha, Xinya Hong, Yongxiang Li*, Hongjiang Song*, Zhiyong Zhang*. Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers. Elife. 2018, 7: e29511. (#Co-First Author, *Corresponding Author, JCR1, SCI, IF: 7.725),2018 [13].Wei Huang, Yanqiu Li, Xiaojing Jia, Chao Qu, Zhen Zhang, Ruixin He, Lizhe Wang, Fengming Ni, Donghe Su, He Huang*, Yaqin Qu*. Targeting HIF1α/miR-22/CDK8/KAT5 feedback loop inhibits hepatocellular carcinoma development. Int. Journal of Engineering Research and Application (Int J Eng Res Appl) , 2017, 7(8): 67-85. (*Corresponding Author, SCI, IF:5.169) [14].Zhipeng Liu, Li Xiong, Guoqing Ouyang, Lun Ma, Sunil Sahi, Kunpeng Wang, L.W. Lin, He Huang, Xiongying Miao, Wei Chen, and Yu Wen. Investigation of Copper Cysteamine Nanoparticles as a New Type of Radiosensitiers for Colorectal Carcinoma Treatment. Scientific reports (Sci Rep), 2017, 7(1):9290. (SCI, JCR1, IF:4.259).[J] [15].Yi Xiao#, Zhenzhen Liu#, Chaonan Liao, Xiaoxiao Mao, Jinxing Cai, Ke Xia, Jun Qi, He Huang*, Tianlun Yang*, Qiong Duan*. Inhibition of BET bromodomain improves anemia in APCmin mice. Leuk Lymphoma, 2017, 58(4):989-992. (*Corresponding Author, SCI, JCR2, IF:2.755) [16].Li Xiong#, Zhipeng Liu#, Guoqing Ouyang, Liangwu Lin, He Huang, Hongxiang Kang, Wei Chen, Xiongying Miao, Yu Wen*, Autophagy inhibition enhances photocytotoxicity of Photosan-II in human colorectal cancer cells, Oncotarget, 2017, 8(4): 6419-6432 (SCI, JCR1, IF:5.008) [17].Wang Ma#, Shengen Yi#, Liangwu Lin, He Huang, Tao Peng, Zhongtao Liu, Zhipeng Liu, Dongni Pei, Xiongying Miao, Yu Wen, Wei Chen*, Li Xiong*. Anticancer effect of photodynamic therapy with photosan-loaded titanium dioxide nanoparticles on Panc-1 pancreatic cancer cells in vitro. Science of Advanced Materials (Sci Adv Mater), 2016, 8(5): 1145-1153 [18].Qiong Duan, Yi Xiao, Zhenzhen Liu, Xiaoxiao Mao, Zhengxiang Zhou, Chaonan Liao, Jinxing Cai, Fulian Huang, Zehao Liu, Jian Zeng, Ke Xia, Cheng Chang, Jun Qi, Zihua Chen*, He Huang*, Tianlun Yang*. BET bromodomain is a novel regulator of TAZ and its activity. BBA-Gene Regul Mech, 2016, 1859(12):1527-1537. (*Corresponding Author, SCI, JCR1, IF: 6.332) [19].Qiong Duan, Xiaoxiao Mao#, Chaonan Liao#, Haoyang Zhou, Zelin Sun, Xu Deng, Qiuning Hu, Jun Qi, Guogang Zhang, He Huang*, Jorge Plutzky*, Tianlun Yang*. Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE?/? mice. Int J Cardiol, 2016, 223:428-432. (*Corresponding Author, SCI, JCR1, IF: 4.638) [20].Zhenzhen Liu#, Yi Xiao#, Zhengxiang Zhou#, Xiaoxiao Mao#, Jinxing Cai, Lu Xiong, Chaonan Liao, Fulian Huang, Zehao Liu, Md Sayed Ali Sheikh, Jorge Plutzky, He Huang*, Tianlun Yang*, Qiong Duan*. Extensive metabolic disorders are present in APC(min) tumorigenesis mice. Mol Cell Endocrinol, 2016, 427:57-64. (*Corresponding Author, SCI,JCR2, IF: 4.241 ) [21].Qiong Duan#, XiaoxiaoMao#, Yi Xiao, Zhenzhen Liu, YanguiWang, Haoyang Zhou, Zhengxiang Zhou, Jinxing Cai, Ke Xia, Qubo Zhu, Jun Qi, He Huang, Jorge Plutzky*, Tianlun Yang*. Super enhancers at the miR-146a and miR-155 genes contribute to self-regulation of inflammation. Biochim Biophys Acta- Gene Regulatory Mechanisms, 2016, 1859(4), 564-571. (SCI, JCR1, IF: 6.332) [22].Chao Qu#, De He#, Xiaoling Lu#, Lihua Dong#, Yuekun Zhu, Qin Zhao, Xin Jiang, Pengyu Chang, Xinping Jiang, Lizhe Wang, Yuyu Zhang, Lirong Bi, Jian He, Yi Peng, Jing Su, Heng Zhang, He Huang, Yan Li, Sufang Zhou, Yaqin Qu*, Yongxiang Zhao*, Zhiyong Zhang*. Salt-inducible Kinase (SIK1) regulates HCC progression and WNT/β-catenin activation. J Hepatol, 2016, 64(5):1076-89. (SCI, JCR1, IF: 11.336) [23].Zhiying Yang, Jianming Li, Ling Xiao, Lin Mou, Yan Cai, He Huang, Xuegang Luo, Xiaoxin Yan. [(3) H]-L685,458 Binding Sites are Abundant in Multiple Peripheral Organs in Rats: Implications for Safety Assessment of Putative γ-Secretase Targeting Drugs. Basic Clin Pharmacol Toxicol, 2014, 115(6):518-26 [24].Tao Yang, Caihong Chen, Bin Zhang, He Huang, Ganqiu Wu, Jianguo Wen, Junwen Liu*. Induction of Krüppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I. FEBS J, 2010, 277(18):3780-8 [25].Mihir Rajurkar#, He Huang#, Jennifer L. Cotton#, Julie K. Brooks, Jason Sicklick, Andrew P. McMahon, Junhao Mao*. Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis. Oncogene, 2014, 33(46):5370-8. (#Co-First Author, SCI, JCR1, IF: 8.559) [26].He Huang#, Jennifer L. Cotton#, Yang Wang, Mihir Rajurkar, Lihua J. Zhu, Brian C. Lewis, Junhao Mao. Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem, 2013, 288(24):17589-17596. (SCI, Nature Index, JCR1, IF:4.651) [27].Jufang Huang, Lei Shang, Mengqi Zhang, Hui Wang, Dan Chen, Jianbin Tong, He Huang, Xiaoxin Yan, Leping Zeng, Kun Xiong*. Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response. BMC Neuroscience, 2013, 14:16. ISSN: 1471-2202 IF:3.091 [28].Mihir Rajurkar, Wilfredo E. De Jesus-Monge, David R. Driscoll, Victoria A Appleman, He Huang, Jennifer L Cotton, David S Klimstra, Lihua Zhu, Karl Simin, Lan Xu, Andrew P McMahon, Brian C Lewis, Junhao Mao*. The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A, 2012, 109(17):E1038-1047. (SCI, Nature Index, JCR1, IF: 9.737) [29].Tao Yang, Caihong Chen, Bin Zhang, He Huang, Ganqiu Wu, Jianguo Wen, Junwen Liu*. Induction of Krüppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I. FEBS J, 2010, 277(18):3780-8. ISSN: 1742-464X IF:3.538 [30].Jing Yang#, Yanjin Wang#, Yan Cai, Zhiying Yang, Ganqiu Wu, Jianguo Wen, Xuegang Luo*, He Huang*. Preparation of rabbit anti-rat LRRN3 polyclonal antibody and study of its expression. Neural Regen Res, 2010,5(13):1030-1034. (*Corresponding Author, SCI ) [31].罗晓敏,邹海燕,张喆,潘爱华,尹芳,魏苗,杨静,黄河*. IGF-1抑制妊娠合并糖尿病诱导的鼠胚胎细胞凋亡, 生物化学与生物物理进展, 2009, 36(6): 776- 780. (*Corresponding Author, SCI ) [32].Kun Xiong, He Huang*, Hui Wang, Yan Cai, Jing Yang, Jufang Huang, Xuegang Luo*. Effects of diethyldithiocarbamate on myelin basic protein expression in the rat lateral olfactory tract. Neural Regeneration Research, 2009, 4(4): 302- 306. (*Corresponding Author, SCI ) [33].Jianhua Tang, Wangjiao He, He Huang, Chaochao Tan, Qiong Duan, Kaijia Wang, Xianyu Yuan, Xujin Zhu. Important roles of glycosylphosphatidylinositol (GPI)-specific phospholipase D and some GPI-anchored proteins in the pathogenesis of hepatocellular carcinoma. Clin Biochem. 2009, 42(4-5):400-407. ISSN: 0009-9120, IF:2.043 [34].Yan Cai#, Jing Yang#, He Huang*, Fang Li, Ganqiu Wu, Jing Yang, Xuegang Luo. Prokaryotic expression and purification of fibronectin leucine rich transmembrane protein 3 C-terminal domain proteins in rats. Neural Regeneration Research, 2009, 4(2): 152- 156. (*Corresponding Author, SCI ) [35].Huaying Liu, Xiaoling Li, Zhaoxia Niu, Liming Zhang, Ming Zhou, He Huang, Jiajin He, Wenling Zhang, Lan Xiao, Yunlian Tang, Li Wang, Guiyuan Li. Preparation of Polyclonal Antibody Specific for BRD7 and Detection of Its Expression Pattern in the Human Fetus. J Histochem Cytochem, 2008, 56(6): 531-538 [36].Minghua Wu#, He Huang#, Qiong Chen, Dan Li, Zhaoyang Zeng, Wei Xiong, Yanhong Zhou, Xiaoling Li, Ming Zhou, Jianhong Lu, Shourong Shen, Guiyuan Li Leucine-rich Repeat C4 Protein is Involved in Nervous Tissue Development and Neurite Outgrowth, and Induction of Glioma Cell Differentiation. Acta Biochimica et Biophysica Sinica, 2007, 39(10): 731-738. (#Co-First Author, SCI) [37].Yang Y, Zhou H, Yang Y, Li W, Zhou M, Zeng Z, Xiong W, Wu M, Huang H, Zhou Y, Peng C, Huang C, Li X, Li G. Lipopolysaccharide (LPS) regulates TLR4 signal transduction in nasopharynx epithelial cell line 5-8F via NFkappaB and MAPKs signaling pathways. Mol Immunol. 2007 Feb,44(5):984-92. IF:2.827 [38].Minghua Wu, Chen Huang, Kai Gan, He Huang, Qiong Chen, Jue Ouyang, Yunlian Tang, Xiayu Li, Yixin Yang, Houde Zhou, Yanhong Zhou, Zhaoyang Zeng, Xiaoling Li, Dan Li, Ke Tang, Shourong Shen, Guiyuan Li*. LRRC4, a Putative Tumor Suppressor Gene, Requires a Functional LRR Cassette Domain to Inhibit Proliferation of Glioma Cells In Vitro by Modulating the ERK/Akt/NF-{kappa}B Pathway. Mol Biol Cell, 2006, 17(8):3534-3542. IF: 7.454 [39].Houde Zhou, Songqin Fan, Jin Zhao, Donghai Huang, Ming Zhou, Huaying Liu, Zhaoyang Zeng, Yixin Yang, He Huang, Xiaoling Li, Shourong Shen, Guiyuan Li*. Tissue distribution of the secretory protein, SPLUNC1, in the human fetus. Histochem Cell Biol. 2005, 30: 1- 10 [40].Jie Zhou, Jian Ma, Bicheng Zhang, Xiaoling Li, Shourong Shen, Shiguo Zhu, Wei Xiong, Huaying Liu, He Huang, Ming Zhou, Guiyuan Li*. BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways. J Cell Physiol, 2004, 200(1): 89- 98. (IF:4.8) [41].Wei Xiong, …, He Huang, …, Gui Yuan Li*. A Susceptibility Locus at Chromosome 3p21 Linked to Familial Nasopharyngeal Carcinoma. Cancer Res, 2004, 64: 1972- 1974. (IF:8.318) [42].彭聪,梁宋平,谭琛,吕红斌,黄河,周鸣,王蓉,李小玲,李桂源.运用蛋白质组学技术研究鼻咽癌候选抑瘤基因BRD7. 生物化学与生物物理学报, 2003, 35(9): 816- 822 [43].熊炜,曾朝阳,沈守荣,李小玲,李伟芳,王蓉,熊芳,彭聪,张秋红,周鸣,杨一新,周厚德,黄河,李桂源. 高频等位基因不平衡位点D6S1581 与鼻咽癌的遗传易感性研究.中华医学遗传学杂志, 2003, 20(4): 311- 314 [44].彭聪,谭琛,张秋红,王晓艳,周鸣,黄河,王蓉,李小玲. 新基因BRD7对鼻咽癌蛋白质表达谱影响的初步研究. 生物化学与生物物理进展, 2003, 30(5): 721- 725

学术兼职

[1] 2012.12-至今 湖南省解剖学会,常务理事、秘书长 [2] 2014.8-至今 中国解剖学会理事 [3] 2014.8-至今 中国解剖学会第十五届组织学与胚胎学分会委员 [4] 2016.7-至今 中国中医药信息研究会临床研究分会常务理事 [5] 2016.6-至今 中华医学会医学细胞生物学分会青年委员 [6] 2012.12-至今 湖南省解剖学会常务理事、秘书长

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