李昌琪 - 中南大学 - 基础医学院

个人简介

研究工作经历: 2010年10月-至今，中南大学，基础医学院人体解剖与神经生物学系，教授 2005年9月-2010年10月，中南大学，基础医学院人体解剖与神经生物学系，副教授 1998年7月-2005年9月，中南大学，基础医学院人体解剖与神经生物学系，讲师主持科研项目（课题）及人才计划项目情况: 1. 湖南省自然科学基金项目，2019JJ40369，早期正、负性事件经历对大鼠前额皮质-下丘脑突触环路重塑的研究，10万元，2019/01-2021/12，主持 2. 国家自然科学基金面上项目，31371212，社会情境下大鼠掠食决策行为脑机制的实验研究，2014/01-2017/12，79万元，已结题，主持 3. 国家自然科学基金面上项目，31171151，大鼠幼年期丰富环境经历对其社会竞争行为的影响与机制，2012/01-2015/12，60万元，已结题，主持 4. 国家自然科学基金面上项目，30971533，吗啡成瘾与戒断事件的跨代影响与机制研究，2010/01-2012/12，31万元，已结题，主持 5 湖南省自然科学基金面上项目，08JJ5034，成年大鼠杏仁核内新神经元的产生与恐惧记忆，2008/01-2010/12, 0.5万元，已结题，主持主要论著（近5年来已发表的主要论著目录）教育经历 1995.9-1998.6 中南大学 | 人体解剖与组织胚胎学 | 硕士学位 | 硕士研究生毕业 2000.9-2004.6 中南大学 | 精神卫生与精神病 | 博士学位 | 博士研究生毕业

研究领域

社会决策行为的脑机制精神行为异常（抑郁、药物成瘾、PTSD）的神经生物学机制

近期论文

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1．Wen-Yu Cao，Zhao-Lan Hu，Yang Xu，Wen-Juan Zhang，Fu-Lian Huang，Xiao-QingQiao，Yan-Hui Cui，Wei Wan，Xue-qin Wang, Dan Liu, Ru-Ping Dai ，Fang Li，Chang-Qi Li* .Role of early environmental enrichment on the social dominance tube test at adulthood in the rat，Psychopharmacology，2017 Nov, 234(22): 3321-3334 2. Wang HT, Huang FL, Hu ZL, Zhang WJ, Qiao XQ, Huang YQ, Dai RP, Li F, Li CQ*. Early-life social isolation-induced depressive-like behavior in rats results in microglial activation and neuronal histone methylation that are mitigated by minocycline. Neurotox Res, 2017, 31: 505-520 3. Fang Li，Wen‑Yu Cao，Fu‑Lian Huang，Wen‑Jing Kang，Xiao‑Lin, Zhong，Zhao‑Lan Hu，Hong‑Tao Wang，Juan Zhang，Jian‑Yi Zhang，Ru‑Ping Dai，Xin‑Fu Zhou, Chang‑Qi Li*. Roles of NMDA and dopamine in food-foraging decision-making strategies of rats in the social setting. BMC Neuroscience, 2016 Jan 11; 17(1):3. doi: 10.1186/s12868-015-0233-8. 4. Luo YW, Xu Y, Cao WY, Zhong XL, Duan J, Wang XQ, Hu ZL, Li F, Zhang JY, Zhou M, Dai RP, Li CQ*. Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress. Neuropharmacology, 2015, 89:318-324. 5. Li CQ, Luo YW, Bi FF, Cui TT, Song L, Cao WY, Zhang JY, Li F, Xu JM, Hao W, Xing XW, Zhou FH, Zhou XF, Dai RP. Development of anxiety-like behavior via hippocampal IGF-2 signaling in the offspring of parental morphine exposure: effect of enriched environment. , Neuropsychopharmacology, 2014 Nov;39(12):2777-87. 6. Cao W, Duan J, Wang X, Zhong X, Hu Z, Huang F, Wang H, Zhang J, Li F, Zhang J, Luo X, Li CQ*. Early enriched environment induces an increased conversion of proBDNF to BDNF in the adult rat's hippocampus. Behav Brain Res. 2014 May 15;265:76-83. 7. Huang F, Yang Z, Liu X, Li CQ*. Melatonin facilitates extinction, but not acquisition or expression, of conditional cued fear in rats. BMC Neurosci. 2014 Jul 15;15:86. 8. Cao WY, Xu Y, Luo YW, Zhong XL, Duan J, Wang XQ, Hu ZL, Li F, Dai RP, Luo XG, Zhang JY, Li CQ*. Activation of ERK1/2 is required for normal response of isosexual social interactions in male rats. Brain Res. 2013 Nov 13;1538:51-60. 9. Li F, Cao WY, Li MB, Xu Y, Zhang JW, Zhang JY, Luo XG, Dai RP, Zhou XF, Li CQ*. A simple method for detection of food foraging behavior in the rat: involvement of NMDA and dopamine receptors in the behavior. Neuroscience, 2012 Mar 15;205:73-80 10. Si Chen, Tuo Liang, Fiona H. Zhou, Ye Cao, Chao Wang, Fei-Yifan Wang,Fang Li, Xin-Fu Zhou, Jian-Yi Zhang and Chang-Qi Li*. Regular Music Exposure in Juvenile Rats Facilitates Conditioned Fear Extinction and Reduces Anxiety after Foot Shock in Adulthood. Biomed Res Int. 2019 Jul 14;2019:8740674. doi: 10.1155/2019/8740674. eCollection 2019 11. Tu BX, Wang LF, Zhong XL, Hu ZL, Cao WY, Cui YH, Li SJ, Zou GJ1, Liu Y, Zhou SF, Zhang WJ, Su JZ, Yan XX, Li F, Li CQ*. Acute restraint stress alters food-foraging behavior in rats: taking the easier way while suffered. Brain Res Bull. 2019 Jul; 149:184-193. 12.Zhaolan Hu, Yanhui Cui, Xiaoqing Qiao, Xinwen He, Fang Li, Cong Luo, Shuang Wang, Changqi Li* and Ruping Dai. Silencing miR-150 ameliorates experimental autoimmune encephalomyelitis. Front Neurosci. 2018 Jul 10;12:465