王洁 - 中南大学 - 基础医学院

个人简介

王洁，女，1973年11月生。中南大学基础医学院免疫学系教师，曾在美国德克萨斯大学圣安东尼奥健康科学中心微生物学与免疫学系任访问学者3年。主要从事免疫相关因子与疾病关系的研究，包括口腔癌前病变及口腔癌的免疫发病机制、肿瘤免疫逃逸与免疫防治、衣原体感染的致病机制及防治等。主持国家自然科学基金2项，湖南省科技计划项目4项，以第2参与人完成国家自然科学基金及湖南省科技计划项目等共7项；发表论文35篇，其中SCI收录论文21篇；获实用新型专利7项；主编（或副主编）教材4本，参编教材7本；获湖南省自然科学奖二等奖1项，获第十届湖南医学科技奖二等奖1项，获2012年中南大学优秀博士学位论文，获校级教学成果奖5项，教学质量优秀奖4项，获中南大学第三届青年教师“十佳教案”奖1项，获中南大学2017年度卢惠霖教学奖励金优秀教师奖。

研究领域

肿瘤免疫感染免疫

近期论文

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[1].A Genome-Wide Profiling of the Humoral Immune Response to Chlamydia trachomatis Infection Reveals Vaccine Candidate Antigens Expressed in Humans.:J Immunol,2010 [2].PTMA, a new identified autoantigen for oral submucous fibrosis, regulates oral submucous fibroblast proliferation and extracellular matrix.:Oncotarget,2017 [3].Oral squamous cell carcinoma suppressed antitumor immunity through induction of PD-L1 expression on tumor-associated macrophages.:Immunobiology,2016 [4].Correlations of abnormally upregulated CC chemokine ligand 18 (CCL18) with clinical stage and cervical lymph node metastasis status in serum and tumor tissue of patients with oral squamous cell carcinoma.:Int J Clin Exp Pathol,2016 [5].Clinico-pathological significance of MHC-I type chain- associated protein A expression in oral squamous cell carcinoma.:Asian Pac J Cancer Prev.,2012 [6].A Genome-Wide Profiling of the Humoral Immune Response to Chlamydia trachomatis Infection Reveals Vaccine Candidate Antigens Expressed in Humans.:J Immunol,2010 [7].A chlamydial type III-secreted effector protein (Tarp) is predominantly recognized by antibodies from humans infected with Chlamydia trachomatis and induces protective immunity against upper genital tract pathologies in mice.:Vaccine,2009 [8].Immunodominant regions of a Chlamydia trachomatis type III secretion effector protein, Tarp.:Clin Vaccine Immunol,2010 [9].Chlamydia muridarum with Mutations in Chromosomal Genes tc0237 and/or tc0668 Is Deficient in Colonizing the Mouse Gastrointestinal Tract.:Infect Immun.,2017 [10].Chlamydia trachomatis antigens recognized in women with tubal factor infertility, normal fertility, and acute infection.:Obstet Gynecol,2012 [11].Genome-wide identification of Chlamydia trachomatis antigens associated with tubal factor infertility.:Fertil Steril,2011 [12].Associationo tubal factor infertility with elevated antibodies to Chlamydia trachomatis caseinolytic protease P.:Am J Obstet Gynecol,2010 [13].Chlamydia vaccine candidates and tools for chlamydial antigen discovery.:Expert Rev. Vaccines.,2009 [14].Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells.:Appl Environ Microbiol,2008 [15].Localization and characterization of GTP-binding protein CT703 in the Chlamydia trachomatis-Infected cells.:Curr Microbiol,2011 [16].Chlamydia trachomatis antigens recognized in women with tubal factor infertility, normal fertility, and acute infection:Obstet Gynecol,2012 [17].A regulator from Chlamydia trachomatis modulates the activity of RNA polymerase through direct interaction with the beta subunit and the primary sigma subunit.:Genes Dev,2009 [18].Cytotoxic T cell responses to Streptococcus are associated with improved prognosis of oral squamous cell carcinoma.:Exp Cell Res,2018 [19].Streptococcus salivarius-mediated CD8+ T cell stimulation required antigen presentation by macrophages in oral squamous cell carcinoma.:Exp Cell Res,2018 [20].Chlamydia trachomatis ct143 stimulates secretion of proininflammatory cytokines via activating the p38/MAPK signal pathway in THP-1 cells.:Molecular Immunology,2019

学术兼职

兼任中国微生物学会医学微生物学与免疫学专委会四体学组副组长，中国微生物学会医学微生物学与免疫学专委会青年学组常务委员，中国微生物学会人兽共患病病原学专业委员会会员，湖南省免疫学会第二届理事会常务理事。