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个人简介

博士生/博士后导师,现任中南大学基础医学院病理学系/湘雅医院病理科副主任、分子病理诊断中心主任。病理学国家级精品课程主讲教师、病理学国家级资源共享课程主讲教师及基础医学形态学国家级教学团队、卫计委临床重点专科骨干成员,副主编及参编《病理学》全国高等学校医学规划教材及配套教材7本,人民卫生出版社国家医学教育题库病理学学科副主编,获校级教学成果奖8项;参与或主持了教育部教改项目、教育部修购专项资助项目、教育部985资助项目、国家自然科学基金及湖南省科技计划项目10项。发表本专业SCI论文30余篇。获湖南省自然科学奖三等奖一项。 教育经历 2003.9-2006.7 中南大学 | 基础医学 | 博士学位 | 研究生(博士)毕业 1999.9-2002.7 中南大学 | 基础医学 | 硕士学位 | 硕士研究生毕业 1991.9-1996.7 湖南医科大学 | 临床医学 | 学士学位 | 本科(学士) 工作经历 2017.9-至今 中南大学 | 教授 2008.9-2017.8 中南大学 | 副教授 2003.9-2008.8 中南大学 | 病理学系 | 讲师 1996.7-2003.8 湖南医科大学 | 病理学系 | 助教 科研项目 染色质重塑蛋白LSH在肺癌细胞DNA损伤修复中的作用及其机制,在研,主持,国家自然科学基金委员会 EphA2调控Wnt/beta-catenin 信号通路的机制研究及其临床意义,已结题,参加,国家自然科学基金委员会 教学成果 病理学标本陈列馆的建设和开放性教学的实践,2006-10-18 病理学教学改革与创新,2004-09-23 病理网络教学探索与学生创新能力培养,2006-07-20 病理学多功能开放性实验平台的设计与建设,2007-08-30 首批国家精品课程”病理学”实验教学的改革与探索,2010-08-30 产学研相结合,促进病理学精品课程可持续发展,2012-10-01 获奖信息 湖南省自然科学奖|2018

研究领域

肺癌、表观遗传学

肺癌,表观遗传学

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Yuqing Wu,Siwei Zhang, Xiaoxiao Gong, Samantha Tam.The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression:Mol Cancer,2020,19(1):39 Shan Lu,Can Lu, YuXuan Xiao, Wei Zhu, QiuYan He, Bin Xie, JianHua Zhou, YongGuang Tao, Shuang Liu.Comparison of EML4-ALK fusion gene positive rate in different detection methods and samples of non–small cell lung cancer:J Cancer,2020,11(6):1525-1531 Yating Liu,Chao Mao, Min Wang, Na Liu, Lianlian Ouyang, Shouping Liu, Haosheng Tang, Ya Cao, Shuang Liu, Xiang Wang, Desheng Xiao, Ceshi Chen.Cancer progression is mediated by proline catabolism in non-small cell lung cancer:oncogene,2020(39(11)):2358-2376 Xinyi Zhang,Kai Xie, Honghua Zhou, Yuwei Wu, Chan Li, Yating Liu, Zhaoya Liu, Qian Xu.Role of non-coding RNAs and RNA modifiers in cancer therapy resistance.[J]:Mol Cancer,2020,19(1):47 Min Wang,Chao Mao, Lianlian Ouyang, Yating Liu, Weiwei Lai, Na Liu, Ying Shi,Ling Chen, Desheng Xiao, Fenglei Yu, Xiang Wang, Hu Zhou, Ya Cao, Shuang Liu, Qin Yan.Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA:Cell Death Differ,2019,26(11):2329-2343 Ling Chen,Ying Shi, Na Liu, Zuli Wang, Rui Yang, Bin Yan, Xiaoli Liu, Weiwei Lai,Yating Liu, Desheng Xiao, Hu Zhou, Yan Cheng, Ya Cao, Shuang Liu.DNA methylation modifier LSH inhibits p53 ubiquitination and transactivates p53 to promote lipid metabolism:Epigenetics Chromatin,2019(12(1)):59 Jingyue Sun,Yao Long, Xin Peng, Desheng Xiao, Jianhua Zhou, Yongguang Tao.The survival analysis and oncogenic effects of CFP1 and 14-3-3 expression on gastric cancer:Cancer Cell Int,2019(19):225 Rui Yang,Na Liu, Ling Chen, Yiqun Jiang, Ying Shi, Chao Mao, Yating Liu, Min Wang, Weiwei Lai, Haosheng Tang, Menghui Gao, Desheng Xiao, Xiang Wang, Hu Zhou, Can-e Tang, Wenliang Liu, Fenglei Yu, Ya Cao, Qin Yan.GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH:Oncogene,2019,38(46):7133-7145 Chunhui Ouyang,Zhenghao Deng, Jianhua Zhou, Chunyan Fu, Shuang Liu, Yongguang Tao.Chromatin remodeling factor lymphoid-specific helicase links with Epstein-Barr virus associated the follicular germinal center B cell lymphomas:J Cancer Res Ther,2019,15(2):350-357 Rui Yang,Na Liu, Ling Chen, Yiqun Jiang, Ying Shi, Chao Mao, Yating Liu, Min Wang, Weiwei Lai, Haosheng Tang, Menghui Gao, Desheng Xiao, Xiang Wang, Fenglei Yu, Ya Cao.LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer:J Exp Clin Cancer Res,2019,38(1):280 Chao Mao,Min Wang, Banglun Qian, Lianlian Ouyang, Ying Shi, Na Liu, Ling Chen, Desheng Xiao, Xiang Wang, Ya Cao, Wenliang Liu.Aryl hydrocarbon receptor activated by benzo (a) pyrene promotes SMARCA6 expression in NSCLC:Am J Cancer Res,2018,8(7):1214-1227 Chao Mao,Xiang Wang, Yating Liu, Min Wang, Bin Yan, Yiqun Jiang, Ying Shi, Yi Shen, Xiaoli Liu, Weiwei Lai, Rui Yang, Desheng Xiao, Yan Cheng, Shuang Liu, Hu Zhou, Ya Cao, Weishi Yu, Kathrin Muegge, Herbert Yu.A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53:Cancer Res,2018,78(13):3484-3496 Shi Y,Liu N, Lai W, Yan B, Chen L, Liu S, Liu S, Wang X, Xiao D, Liu X, Mao C, Jiang Y, Jia J, Liu Y, Yang R, Cao Y.Nuclear EGFR-PKM2 axis induces cancer stem cell-like characteristics in irradiation-resistant cells:Cancer Lett,2018,422:81-93 Bin Yan,Ying Shi, Na Liu, Ling Chen, Xiang Wang, Desheng Xiao, Xiaoli Liu,Chao Mao, Yiqun Jiang, Weiwei Lai, Xing Xin, Can-E Tang, Dixian Luo, Tan Tan, Jiantao Jia,Yating Liu, Rui Yang, Jun Huang, Hu Zhou, Yan Cheng, Ya Cao, Weishi Yu, Kathrin Muegge.Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance:Cell Death Dis,2018,9(5):490 Bin Xie,Zhenghao Deng, Yu Pan, Chunyan Fu, Songqing Fan, Yongguang Tao, Jianhua Zhou.Post-transcriptional regulation DPC4 gene by miR-190 in colorectal cancer cells:J Cancer Res Ther,2018,14(4):838-843 Hongyu Liu,Cheng Lei, Qin He, Zou Pan, Desheng Xiao.Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer:Mol Cancer,2018,17(1):64 Jiantao Jia, Ying Shi,Ling Chen, Weiwei Lai, Bin Yan, Yiqun Jiang, Desheng Xiao, Sichuan Xi, Ya Cao, Shuang Liu, Yan Cheng.Decrease in Lymphoid Specific Helicase and 5-hydroxymethylcytosine Is Associated with Metastasis and Genome Instability:Theranostics,2017,7(16):3920-3932 Yiqun Jiang,Chao Mao, Rui Yang, Bin Yan, Ying Shi, Xiaoli Liu, Weiwei Lai, Yating Liu, Xiang Wang, Desheng Xiao, Hu Zhou, Yan Cheng, Fenglei Yu, Ya Cao, Shuang Liu, Qin Yan.EGLN1/c-Myc Induced Lymphoid-Specific Helicase Inhibits Ferroptosis through Lipid Metabolic Gene Expression Changes:Theranostics,2017,7(13):3293-3305 Desheng Xiao,Jun Huang, Yu Pan, Hao Li, Chunyan Fu, Chao Mao, Yan Cheng, Ying Shi, Ling Chen, Yiqun Jiang, Rui Yang, Yating Liu, Jianhua Zhou, Ya Cao, Shuang Liu.Chromatin Remodeling Factor LSH is Upregulated by the LRP6-GSK3β-E2F1 Axis Linking Reversely with Survival in Gliomas:Theranostics,2017,7(1):132-143 Yangying Zhou,Bin Xie, Yumei Duan, Weiping Su, Xiaoping Yi, Wei Liu, Chunyan Fu, Yongguang Tao, Jianhua Zhou.Primary gastric malignant melanoma might originate from amine precursor uptake and decarboxylation cells:Int J Clin Exp Pathol,2016(9(12)):13003-13009 Xiaozhen He, Bin Yan, Shuang Liu,Jiantao Jia, Weiwei Lai, Xing Xin, Can-e Tang, Dixian Luo, Tan Tan, Yiqun Jiang, Ying Shi, Yating Liu, Desheng Xiao, Ling Chen, Shao Liu, Chao Mao, Gang Yin, Yan Cheng, Jia Fan, Ya Cao, Kathrin Muegge.Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase:Cancer Research,2016,76(19):5743-5755 Desheng Xiao,Ying Shi, Chunyan Fu, Jiantao Jia, Yu Pan, Yiqun Jiang, Ling Chen, Shuang Liu, Wen Zhou, Jianhua Zhou.Decrease of TET2 expressionand increase of 5-hmC levels in myeloid sarcomas:Leukemia Research,2016,42:75-79 Yu Pan,Yongguang Tao, Chunyan Fu, Jiantao Jia, Shuang Liu.Assessment of PET/CT in multifocal myeloid sarcomas with loss of TET2: a case report and literature review:Int J Clin Exp Pathol,2015,8(10):13630-4 Desheng Xiao, Kuansong Wang,Huiqiu Cao, Zhenghao Deng, Yongbin Hu, Xia-hui Qu, Jifang Wen.Inhibition of fibroblast growth factor 2-induced apoptosis involves surviving expression, protein kinase Cα activation and subcellular translocation of Smac in human small cell lung cancer cells:Acta Biochim Biophy Sin,2008(40):297-303 .Effect of DPC4 gene on invasion and metastasis of colorectal carcinoma cells:Acta Biochim Biophy Sin,2006,38:883-892

学术兼职

中国医师协会病理学分会分子病理学组委员 中国医学装备人工智能联盟病理委员会常委 中国医疗保健国际交流促进会病理专业委员会委员 全国卫生产业企业管理协会实验医学专家委员会委员 中国研究型医院学会超微与分子病理学专业委员会委员 湖南省医师协会病理科医师分会副会长 湖南省医学会病理学专业委员会委员 湖南省临床病理质量控制中心委员 湖南省抗癌协会肺癌专业委员会委员

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