张兰 - 中国科学院植物保护研究所 -

个人简介

张兰，女，1978年11月出生，辽宁葫芦岛人，博士，副研究员，硕士生导师。 2002年7月获中国农业大学植物保护专业学士学位，2007年6月获中国农业大学农学博士学位。1999.07 至今，在中国农科院植保所从事农药毒理及天然产物化学研究工作。工作期间主持国家自然科学基金项目4项，作为骨干参加国家重点研发计划项目1项，参加多项国家自然科学基金及农业公益性行业科技专项。以第一作者或通讯作者发表 SCI 论文 13篇，参编著作 1 部，获中华科技奖一等奖 1 项（第15完成人）。

研究领域

现从事植物源农药研发和作用机制和农药环境毒理研究。在植物源活性物质对昆虫细胞诱导凋亡作用机制研究和植物源活性物质作用靶标探索取得进步。在昆虫毒理和分子生物学方面研究较多，对由于昆虫靶标不敏感和解毒代谢能力增强而导致的杀虫剂不敏感机制研究取得成绩。具有农药环境安全评价毒理试验能力。

近期论文

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1、Ren X, Zhang L, Zhang Y, Mao L, Jiang H. 2017. Mitochondria response to camptothecin and hydroxycamptothecine-induced apoptosis in Spodoptera exigua cells. Pestic Biochem Physiol. 140:97-104. 2、Zhang P, Zhang L, Zhang Y, Mao L, Jiang H. 2017. Substitutions in Spodoptera exigua topoisomerase I modulate its relaxation activity and camptothecin sensitivity. Pest Manag Sci. 73:1179-1186 3、Wang L, Li Z, Zhang L, Zhang Y, Mao L, Jiang H. 2017. Synthesis, insecticidal activity and inhibition on topoisomerase I of 20(S)-t-Boc-amino acid derivatives of camptothecin. Pestic Biochem Physiol. 139:46-52. 4、Zhang Y, Zhang L, Feng L, Mao L, Jiang H. 2017. Oxidative stress of imidaclothiz on earthworm Eisenia fetida, Comparative Biochemistry and Physiology, Part C, 191: 1-6. 5、Feng L, Zhang L, Zhang Y, Zhang P, Jiang H. 2015. Inhibition and recovery of biomarkers of earthworm Eisenia fetida after exposure to thiacloprid, Environmental Science and Pollution Research. 22: 9475-9482. 6、Zhang L, Feng X, Ma D, Yang J, Jiang H, Zhang Y, He W. 2013. Brusatol Isolated from Brucea javanica (L.) Merr. Induces Apoptotic Death of Insect Cell Lines. Pestic Biochem Physiol. 107: 18–24. 7、Zhang L, Ma D, Zhang Y, He W, Yang J, Li C, Jiang H. 2013. Characterization of DNA topoisomerase-1 in Spodoptera exigua for toxicity evaluation of camptothecin and hydoxy-camptothecin. PLoS One. 8:e56458. 8、Zhang L, Zhang Y, He W, Ma D, Jiang H. 2012. Effects of camptothecin and hydrocamptothecin on insect cell lines Sf21 and IOZCAS-Spex-II. Pest Manag Sci. 68: 652-657. 9、Shi J, Zhang L, Gao X. 2011. Characterisation of spinosad resistance in the housefly Musca domestica (Diptera: Muscidae). Pest Manag Sci. 67:335-340. 10、Li J, Wang Q, Zhang L, GaoX. 2012. Characterization of imidacloprid resistance in the housefly Musca domestica (Diptera: Muscidae)，Pestic Biochem Physiol. 102:109-114. 11、Zhang L, Shi J, Shi X, Liang P, Gao J, Gao X. 2010. Quantitative and qualitative changes of the carboxylesterase associated with beta-cypermethrin resistance in the housefly, Musca domestica (Diptera: Muscidae). Comp Biochem Physiol B: Biochemistry & Molecular Biology. 156: 6-11. 12、Zhang L, Shi J, Gao X. 2008. Inheritance of beta-cypermethin resistance in a strain of the housefly, Musca domestica (Diptera: Muscidae), Pest Manag Sci. 64: 185-190. 13、Zhang L, Gao X, Liang P. 2007. Beta-cypermethrin resistance associated with high carboxylesterase activity in a strain of house fly, Musca domestica (Diptera: Muscidae), Pestic Biochem Physiol. 89: 65-72,