章海兵 - 中国科学院上海营养与健康研究所 -

个人简介

2017–至今：中国科学院上海营养与健康研究所研究员 2013-2016年：中国科学院上海生命科学研究院营养科学研究所研究员 2012-2013年：费城儿童医院博士后 2006-2012年：托马斯杰弗逊大学博士后 2000-2006年：中科院上海生命科学研究院健康研究所博士 1993-1997年：山东大学微生物系

研究领域

细胞死亡与免疫代谢，细胞死亡是维持多细胞生命活动的基础，过多或过少的细胞死亡都会引起疾病的发生。细胞死亡主要包括细胞凋亡和细胞坏死，而近年发现的细胞程序性坏死（Necroptosis）是由包含RIP1/RIP3/MLKL的坏死复合物精密调控的一种重要细胞坏死形式，并且显示细胞程序性坏死通过多种途径参与炎症信号的调控。本研究组主要研究细胞程序性坏死与炎症的调控机制，及在相关代谢性疾病中的作用机理。通过探索细胞程序性坏死、炎症与代谢性疾病之间的作用关系，为相关疾病的防治提供理论依据。

近期论文

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H Zhang, XX Wu, XM Li, M Li, F Li, LX Wang, XX Zhang, Y Zhang, Y Luo, H Zhang*. Crucial role of the Receptor-interacting protein homotypic interaction motifs (RHIM) of RIPK3 in RIPK1 dependent cell death and lymphoproliferative disease. Cell Reports. 2020 May 19;31(7):107650. XX Zhang#, HW Zhang#, CX Xu, XM Li, M Li, XX Wu, WJ Pu, B Zhou, HK Wang, DL Li, QR Ding, H Ying, H Wang, H Zhang*. Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Communication. 2019 Sep 13;10(1):4158. Zhao Q#, Yu X#, Li M, Liu Y, Han Y, Zhang X, Li XM, Wu X, Qin J, Fang J, Zhang H*. MLKL attenuates colon inflammation and colitis-tumorigenesis via suppression of inflammatory responses. Cancer Letter. 2019 Sep 10;459:100-111. C Xu, X Wu, X Zhang, Q Xie, C Fan, H Zhang*. Embryonic lethality and host immunity of RelA-deficient mice is mediated by both apoptosis and necroptosis. Journal of Immunology. 2018 Jan 1;200(1):271-285. Zhang X, Zhang H*. Chemotherapy drugs induce pyroptosis through caspase-3-dependent cleavage of GSDME. Sci China Life Sci. 2018 Jun;61(6):739-740. Zhao Q, Yu X, Zhang H, Liu Y, Zhang X, Wu X, Xie Q, Li M, Ying H, H Zhang*. RIPK3 Mediates Necroptosis during Embryonic Development and Postnatal Inflammation in Fadd-Deficient Mice. Cell Reports. 2017 Apr 25;19(4):798-808. Y Liu#, C Fan#, Y Zhang, X Yu, X Wu, X Zhang, Q Zhao, H Zhang, Q Xie, M Li, X Li, Q Ding, H Ying, D Li, H Zhang*. RIP1 Kinase Activity dependent roles in embryonic development of Fadd-deficient mice. Cell Death and Differentiation. 2017 Aug;24(8):1459-1469. X Yu#, Q Zhao#, X Zhang, H Zhang, Y Liu, X Wu, M Li, X Li , J Zhang, X Ruan, H Zhang*. Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation. Oncotarget. 2017 Jun 27;8(40):67300-67314. X Zhang#, C Fan#, HW Zhang, Q Zhao, Y Liu, C Xu, Q Xie, X Wu, X Yu, J Zhang, H Zhang*. MLKL and FADD are Critical for Suppressing Progressive Lymphoaccumulative Disease and Activating NLRP3 Inflammasome. Cell Reports. 2016 Sep 20;16(12):3247-3259. C Fan, W Pu, X Wu, X Zhang, L He, B Zhou*, H Zhang*. Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality. Cell Death and Disease. 2016 Sep 1;7(9):e2351. Yu X, Zhao Q, Zhang H, Fan C, Zhang X, Xie Q, Xu C, Liu Y, Wu X, Han Q*, H Zhang*. Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages. Acta Biochim Biophys Sin. 2016 May;48(5):454-461. Zhang HW, Zhang X, Fan C, Xie Q, Xu C, Qun Zhao, Liu Y, Wu X, H Zhang*. A novel sgRNA selection system for CRISPR-Cas9 in mammalian cells. Biochem Biophys Res Commun. 2016 Mar 18;471(4):528-532. Zhang H, Zhou X, McQuade T, Li J, Chan FK*, Zhang J*. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature. 2011 Mar 17;471(7338):373-376. Zhang H, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang J*. A role for cFLIP in B cell proliferation and stress MAPK regulation. J Immunol. 2009 Jan 1;182(1):207-215. Zhang H#, Hou YJ#, Han SY, Zhang EC, Huebner K, Zhang J*. Mammalian nitrilase 1 homologue Nit1 is a negative regulator in T cells. Int Immunol. 2009 Jun;21(6):691-703.