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招生专业 0710Z2-计算生物学 086000-生物与医药 招生方向 表观遗传组学 教育背景 2000-09--2005-07 北京大学 博士 1996-09--2000-07 北京大学 学士 工作简历 2012-01~现在, 中科院上海生命科学研究院计算生物学研究所, 研究员 2005-09~2011-12,美国国立健康研究院, 博士后研究助理 2000-09~2005-07,北京大学, 博士 1996-09~2000-07,北京大学, 学士 科研项目 ( 1 ) Th2 细胞分化过程中染色质长距离相互作用的调控功能, 主持, 国家级, 2013-01--2016-12 ( 2 ) 干细胞衰老的细胞分子机理及转化应用研究, 参与, 国家级, 2015-05--2019-08 ( 3 ) 细胞转分化过程中染色质高级结构的动态变化及其调控机制, 主持, 国家级, 2018-01--2021-12 ( 4 ) 非编码RNA介导的染色质高级结构动态变化对骨骼肌细胞谱系命运决定的调控功能及分子机制(中胚层), 参与, 国家级, 2016-07--2020-12

近期论文

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(1) Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model, Clinicla Epigenetics, 2016, 通讯作者 (2) A positive role for polycomb in transcriptional regulation via H4K20me1, Cell Research, 2016, 通讯作者 (3) Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes, Development, 2016, 第 4 作者 (4) Comparison of REST cistromes across human cell types reveals common and context-specific functions, PLoS Computational Biology, 2014, 第 4 作者 (5) Understanding human diseases with high-throughput quantitative measurement and analysis of molecular signatures, Science of China, 2013, 第 2 作者 (6) The transcription factor T-bet is induced by multiple pathways and prevents an endogenous Th2 cell program during Th1 cell responses, Immunity, 2012, 第 4 作者 (7) c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells., Cell, 2012, 第 3 作者 (8) Genome-wide mapping of nucleosome occupancy, histone modifications, and gene expression using next-generation sequencing technology, Methods of Enzymology, 2012, 第 1 作者 (9) Characterization of genome-wide enhancer-promoter interactions reveals co-expression of interacting genes and modes of higher order chromatin organization, Cell Research, 2012, 第 2 作者 (10) Genome-wide analyses of transcription factor GATA3-mediated gene regulation in distinct T cell types, Immunity, 2011, 第 1 作者 (11) Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription, Nature Structural and Molecular Biology, 2011, 第 2 作者 (12) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma, Immunity, 2010, 第 3 作者 (13) Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq, Cell Research, 2010, 第 3 作者 (14) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells, Proc Natl Acad Sci USA, 2009, 第 2 作者 (15) H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions, Nature Genetics, 2009, 第 3 作者 (16) Detection of single nucleotide variations in expressed exons of the human genome using RNA-Seq, Nucleic Acids Research, 2009, 第 2 作者 (17) Down-regulation of Gfi-1 expression by TGF-beta is important for differentiation of Th17 and CD103+ inducible regulatory T cells, Journal of Experimental Medicine, 2009, 第 3 作者 (18) Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells, Immunity, 2009, 第 1 作者

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