当前位置: X-MOL首页全球导师 国内导师 › 邱菊

个人简介

2017-至 今 中国科学院上海营养与健康研究所 研究员 2014-2016年 中国科学院上海生命科学研究院/上海交通大学医学院 健康科学研究所 研究员 2009-2014年 西北大学Feinberg医学院 微生物与免疫学系 博士后 2009.04-2009.11 爱因斯坦医学院 细胞生物学系 博士后 2004-2009年 上海交通大学医学院 免疫学 医学博士 1999-2004年 泰山医学院(现山东第一医科大学)临床医学 学士

研究领域

粘膜免疫与天然淋巴细胞,天然淋巴细胞(Innate lymphoid cells, ILC)是一群谱系阴性(Lin-)、缺乏T、B细胞抗原特异性受体的天然免疫细胞亚群。ILC广泛存在于多种器官及粘膜组织,在感染性疾病、过敏性疾病、自身免疫病及肿瘤中发挥重要作用。我们利用炎症性疾病模型、细胞过继转移、细胞体外分化、多色流式及生物信息学等手段,主要研究调控ILC2和ILC3发育和功能的分子机制及对炎症性疾病的影响,以为诊断或治疗炎症性疾病提供理论依据和新手段。

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Qi X, Qiu J, Chang J, Ji Y, Yang Q, Cui G, Sun L, Chai Q, Qin J* and Qiu J*. (2020) Brg1 restrains the pro-in?ammatory properties of ILC3s and modulates intestinal immunity. Mucosal Immunol. Jul 1. doi: 10.1038/s41385-020-0317-3. link: https://rdcu.be/b5mgc Yaya Pian, Qian Chai, Boyang Ren, Yue Wang, Mengjie Lv, Ju Qiu, Mingzhao Zhu. (2020) Type 3 Innate Lymphoid Cells Direct Goblet Cell Differentiation via the LT-LTβR Pathway During Listeria Infection. J Immunol. Jun 26;ji2000197 Deng T, Suo C, Chang J, Yang R, Li J, Cai T, Qiu J*. (2020) ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice. Cell Mol Immunol. 17(2):163-177 Li J#, Shi W#, Sun H, Ji Y, Chen Y, Guo X, Sheng H, Shu J, Zhou L, Cai T and Qiu J*. (2019) Activation of DR3 signaling causes loss of ILC3s and exacerbates intestinal inflammation. Nat Commun. Jul 29;10(1):3371 Ting Cai#, Jinxin Qiu#, Yan Ji, Wenjing Li, Zhaoyun Ding, Caixia Suo, Jiali Chang, Jingjing Wang, Rui He, Youcun Qian, Xiaohuan Guo, Liang Zhou, Huiming Sheng*, Lei Shen*, Ju Qiu*. (2019) IL-17-producing-ST2+ILC2 plays a pathogenic role in lung inflammation. J Allergy Clin Immunol. 143(1):229-244 Ye J*, Qiu J*, Bostick JW, Ueda A, Schjerven H, Li S, Jobin C, Chen ZE, Zhou L. (2017) The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells. Cell Rep. 21(8):2277-2290 Suo C, Fan Z, Zhou L, Qiu J*. (2017) Perfluorooctane sulfonate affects intestinal immunity against bacterial infection. Sci Rep. 7(1):5166 Ruomeng Qiu, Wenli Shi, Ting Cai, Siyu Pei, Ting Tang, Yafei Huang, Huan Wang, Liming Shao, Ju Qiu*, Yonghui Wang*. (2016) Design, synthesis and phenotypic evaluation of N-biaryl amides for IL-17A suppression. Med Chem Commun. 7,2344-2348 Song Y, Kumar V, Wei HX, Qiu J, Stanley P. (2016) Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development. J Immunol. 196,232-243 Song X, Dai D, He X, Zhu S, Yao Y, Gao H, Wang J, Qu F, Qiu J, Wang H, Li X, Shen N, Qian Y. (2015) Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage. Immunity. 43,488-501 Liu Q, Huang X, Oh JH, Lin RZ, Duan S, Yu Y, Yang R, Qiu J, Melero-Martin JM, Pu WT, Zhou B. (2014) Epicardium-to-fat transition in injured heart. Cell Res. 24,1367-1369 Heller JJ, Schjerven H, Li S, Lee A, Qiu J, Chen ZM, Smale ST, Zhou L. (2014) Restriction of IL-22-producing T cell responses and differential regulation of regulatory T cell compartments by zinc finger transcription factor Ikaros. J Immunol. 193,3934-3946 Guo X, Qiu J, Tu T, Yang X, Deng L, Anders RA, Zhou L, Fu YX. (2014) Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection. Immunity. 40,25-39 Qiu J, Zhou L. (2013) Aryl hydrocarbon receptor promotes RORγt(+) group 3 ILCs and controls intestinal immunity and inflammation. Semin Immunopathol. 35(6):657-670 Qiu J, Guo X, Chen ZM, He L, Sonnenberg GF, Artis D, Fu YX, Zhou L. (2013) Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora. Immunity. 39,386-399 Do-Umehara HC, Chen C, Urich D, Zhou L, Qiu J, Jang S, Zander A, Baker MA, Eilers M, Sporn PH, Ridge KM, Sznajder JI, Budinger GR, Mutlu GM, Lin A, Liu J. (2013) Suppression of Inflammation and Acute Lung Injury by Miz1 via Repression of C/EBP-δ. Nat Immunol. 14(5):461-469 Qiu J, Heller JJ, Guo X, Chen ZM, Fish K, Fu YX, Zhou L. (2012) The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells. Immunity. 36,92-104 Heller JJ, Qiu J, Zhou L. (2011) Nuclear receptors take center stage in Th17 cell-mediated autoimmunity. J Clin Invest. 121(2):519-521 Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ. (2008) Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis. J Immunol. 181,1491-1498 Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G. (2007) Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1. Nat Immunol. 8,817-824 Wang Z#, Qiu J#, Guo TB#, Liu A#, Wang Y#, Li Y*, Zhang JZ#*. (2007) Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis. J Immunol. 179,5958-5965

推荐链接
down
wechat
bug