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Hu X, Guo F*. Amino Acid Sensing in Metabolic Homeostasis and Health. Endocr Rev 2020 Oct 14:bnaa026 (Invited review)
#Selected as "Featured article" by Endocrine Reviews.
Yuan F#, Yin H#, Deng Y, Jiao F, Jiang H, Niu Y, Chen S, Ying H, Zhai Q, Chen Y, Guo F*. Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling. Mol Metab 2020 Dec;42:101084
Yuan F, Jiang H, Yin H, Jiang X, Jiao F, Chen S, Ying H, Chen Y, Zhai Q, Guo F*. Activation of GCN2/ATF4 Signals in Amygdalar PKC-δ Neurons Promotes WAT Browning Under Leucine Deprivation. Nat Commun 2020 Jun 5;11(1):2847
Deng J, Guo Y, Yuan F, Chen Si, Yin H, Jiang X, Jiao F, Wang F, Ji H, Hu G, Ying H, Chen Y, Zhai Q, Xiao F*, Guo F*. Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening. Autophagy 2020 Mar;16(3):451-465
Hu X, Deng J, Yu T, Chen S, Ge Y, Zhou Z, Guo Y, Ying H, Zhai Q, Chen Y, Yuan F, Niu Y, Shu W, Chen H, Ma C, Liu Z*, Guo F*. ATF4 Deficiency Promotes Intestinal Inflammation in Mice by Reducing Uptake of Glutamine and Expression of Antimicrobial Peptides. Gastroenterology 2019 Mar;156(4):1098-1111
Xiao F, Guo Y, Deng J, Yuan F, Xiao Y, Hui L, Li Y, Hu Z, Zhou Y, Li K, Han X, Fang Q, Jia W, Chen Y, Ying H, Zhai Q, Chen S, Guo F*. Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals. Mol Metab 2019 Feb;20:138-148
Deng Y, Xiao Y, Yuan F, Liu Y, Jiang X, Deng J, Fejes-Toth G, Naray-Fejes-Toth A, Chen S, Chen Y, Ying H, Zhai Q, Shu Y*, Guo F*. SGK1/FOXO3 signaling in hypothalamic POMC neurons mediates glucocorticoid-increased adiposity. Diabetes 2018 Apr;67(4):569-580
Guo Y, Yu J, Wang C, Li K, Liu B, Du Y, Xiao F, Chen S, Guo F*. miR-212-5p suppresses lipid accumulation by targeting FAS and SCD1. J Mol Endocrinol 2017 Oct;59(3):205-217
Xiao Y, Deng Y, Yuan F, Xia T, Liu H, Li Z, Chen S, Liu Z, Ying H, Liu Y, Zhai Q, Guo F*. An ATF4-ATG5 signaling in hypothalamic POMC neurons regulates obesity. Autophagy 2017 Jun 3;13(6):1088-1089
Wang L, Pan Y, Huang M, You X, Guo F, Chen Y*. PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling. Cell Signal 2017 May;33:98-106
He C#, Yu T#, Shi Y, Ma C, Yang W, Fang L, Sun M, Wu W, Xiao F, Guo F, Chen M, Yang H, Qian J, Cong Y, Liu Z*. MicroRNA 301A promotes intestinal inflammation and colitis-associated cancer development by inhibiting BTG1. Gastroenterology 2017 May;152(6):1434-1448.e15
Xiao Y, Deng Y, Yuan F, Xia T, Liu H, Li Z, Liu Z, Ying H, Liu Y, Zhai Q, Chen S, Guo F*. An ATF4/ATG5 signaling in hypothalamic POMC neurons regulates fat mass via affecting energy expenditure. Diabetes 2017 May;66(5):1146-1158
Deng J#, Yuan F#, Guo Y, Xiao Y, Niu Y, Deng Y, Han X, Guan Y, Chen S, Guo F*. Deletion of ATF4 in AgRP neurons promotes fat loss mainly via increasing energy expenditure. Diabetes 2017 Mar;66(3):640-650
Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y*. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology 2016;64(2):425-438
Li K#, Xiao Y#, Yu J, Xia T, Liu B, Guo Y, Deng J, Chen S, Wang C, Guo F*. Liver-specific gene inactivation of the transcription factor ATF4 alleviates alcoholic liver steatosis in mice. The Journal of Biological Chemistry 2016;291(35):18536-18546
Guo Y#, Yu J#, Deng J, Liu B, Xiao Y, Li K, Xiao F, Yuan F, Liu Y, Chen S, Guo F*. A novel function of hepatic FOG2 in insulin sensitivity and lipid metabolism through peroxisome proliferator–activated receptor alpha. Diabetes 2016;65(8):2151-2163
Xiao F#, Deng J#, Guo Y, Niu Y, Yuan F, Yu J, Chen S, Guo F*. BTG1 ameliorates liver steatosis by decreasing stearoyl-CoA desaturase 1 (SCD1) abundance and altering hepatic lipid metabolism. Science Signaling 2016;9(428):ra50
Xiao Y#, Liu H#, Yu J, Zhao Z, Xiao F, Xia T, Wang C, Li K, Deng J, Guo Y, Chen S, Chen Y, Guo F*. MAPK1/3 regulate hepatic lipid metabolism via ATG7-dependent autophagy, Autophagy 2016, 12(3):592-593
Xiao Y#, Liu H#, Yu J, Zhao Z, Xiao F, Xia T, Wang C, Li K, Deng J, Guo Y, Chen S, Chen Y, Guo F*. Activation of ERK1/2 ameliorates liver steatosis in leptin receptor deficient (db/db) mice via stimulating ATG7-dependent autophagy, Diabetes 2016, 65(2):393-405
Xiao F, Deng J, Yu J, Guo Y, Chen S, Guo F*. A novel function of B-cell translocation gene 1 (BTG1) in the regulation of hepatic insulin sensitivity in mice via c-Jun. The FASEB Journal 2016;30(1):348-359
Li K, Zhang J, Yu J, Liu B, Guo Y, Deng J, Chen S, Wang C*, Guo F*. MicroRNA-214 suppresses gluconeogenesis by targeting activating transcriptional factor 4. The Journal of Biological Chemistry 2015;290(13):8185-8195
Xia T#, Zhang Q#, Xiao Y, Wang C, Yu J, Liu H, Liu B, Zhang Y, Chen S, Liu Y, Chen Y, Guo F*. CREB/TRH pathway in the central nervous system regulates energy expenditure in response to deprivation of an essential amino acid. International Journal of Obesity 2015;39(1):105-113
Yu J, Xiao F, Guo Y, Deng J, Liu B, Zhang Q, Li K, Wang C, Chen S, Guo F*. Hepatic phosphoserine aminotransferase 1 (PSAT1) regulates insulin sensitivity in mice via tribbles homolog 3 (TRB). Diabetes 2015;64(5):1591-1602
Xiao F#, Xia T#, Lv Z#, Zhang Q, Xiao Y, Yu J, Liu H, Deng J, Guo Y, Wang C, Li K, Liu B, Chen S, Guo F*. Central prolactin receptors (PRLRs) regulate hepatic insulin sensitivity in mice via signal transducer and activator of transcription 5 (STAT5) and the vagus nerve. Diabetologia 2014;57(10):2136-2144
Xiao F#, Yu J#, Liu B, Guo Y, Li K, Deng J, Zhang J, Wang C, Chen S, Du Y, Lu Y, Xiao Y, Zhang Z, Guo F*. A novel function of MicroRNA 130a-3p in hepatic insulin sensitivity and liver steatosis. Diabetes 2014;63(8):2631-2642
Xiao F, Yu J, Guo Y, Deng J, Li K, Du Y, Chen S, Zhu J*, Sheng H*, Guo F*. Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice. Metabolism-Clinical and Experimental 2014;63(6):841-850
Yan S, Zhang Q, Zhong X, Tang J, Wang Y, Yu J, Zhou Y, Zhang J, Guo F, Liu Y, FitzGerald GA, Yu Y*. I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT. Diabetes 2014;63(9):2911-2923
Zhang Q, Liu B, Cheng Y, Meng Q, Xia T, Jiang L, Chen S, Liu Y*, Guo F*. Leptin signaling is required for leucine deprivation-enhanced energy expenditure. The Journal of Biological Chemistry 2014;289(3):1779-1787
Wang L, Wang X, Li Z, Xia T, Zhu L, Liu B, Zhang Y, Xiao F, Pan Y, Liu Y, Guo F, Chen Y*. PAQR3 has modulatory roles in obesity, energy metabolism and leptin signaling. Endocrinology 2013;154(12):4525-4535
Yu J#, Xiao F#, Zhang Q, Liu B, Guo Y, Lv Z, Xia T, Chen S, Li K, Du Y, Guo F*. Prolactin receptor (PRLR) regulates hepatic insulin sensitivity in mice via signal transducer and activator of transcription (STAT)5. Diabetes 2013;62(9):3103-3113
Zhang Q, Yu J, Lv Z, Liu B, Xia T, Xiao F, Chen S, Guo F*. Central activating transcription factor (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve. Diabetes 2013;62(7):2230-2239
Wang X, Wang L, Zhu L, Pan Y, Xiao F, Liu W, Wang Z, Guo F, Liu Y, Thomas WG, Chen Y*. PAQR3 modulates insulin signaling by shunting phosphoinositide 3-Kinase p110α to the golgi apparatus. Diabetes 2013;62(2):444-456
Wang C, Xia T, Du Y, Meng Q, Li H, Liu B, Chen S, Guo F*. Effects of ATF4 on PGC1a expression in brown adipose tissue and metabolic responses to cold stress. Metabolism-Clinical and Experimental 2013;62(2):282-289
Xia T, Cheng Y, Zhang Q, Xiao F, Liu B, Chen S, Guo F*. S6K1 in the central nervous system regulates energy expenditure via MC4R/corticotrophin -releasing hormone pathways in response to deprivation of an essential amino acid. Diabetes 2012;61(10):2461-2471
Du Y, Meng Q, Zhang Q, Guo F*. Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT. Amino Acids 2012;43(2):725-734
Chen Y*, Lin X, Liu Y, Xie D, Fang J, Le Y, Ke Z, Zhai Q, Wang H, Guo F, Wang F, Liu Y. Research advances at the institute for nutritional sciences at Shanghai, China. Advances in Nutrition 2011;2(5):428-439
Cheng Y#, Zhang Q#, Meng Q, Xia T, Huang Z, Wang C, Liu B, Chen S, Xiao F, Du Y, Guo F*. Leucine deprivation stimulates fat loss via increasing corticotrophin releasing hormone (CRH) expression in the hypothalamus and activating sympathetic nervous system (SNS). Molecular Endocrinology 2011;25(9):1624-1635
Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, Liu Y, Guo F*. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes 2011;60(3):746-756
Zhang Q, Li H, Guo F*. Amygdala, an important regulator for food intake (Invited Review). Frontier in Biology 2011;6:82-85
Cheng Y#, Meng Q#, Wang C, Li H, Huang Z, Chen S, Xiao F, Guo F*. Leucine deprivation decreases fat mass by stimulation of lipolysis in WAT and upregulation of UCP1 in BAT. Diabetes 2010;59(1):17-25
Wang C, Huang Z, Du Y, Cheng Y, Chen S, Guo F*. ATF4 regulates lipid metabolism and thermogenesis. Cell Res 2010;20(2):174-184
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