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个人简介

招生专业 071005-微生物学 071009-细胞生物学 085238-生物工程 招生方向 登革热、基孔肯雅病毒和寨卡病毒致病的细胞机理 登革热、基孔肯雅病毒和寨卡病毒疫苗和特效药的开发 其他新发病毒Co-infection和virus-virus interaction相关研究 教育背景 2009-02--2009-12 里昂高等师范学院ENS de Lyon (Normal Superior School) Habilitation to Direct Research (HDR) 1997-10--2000-11 法国国家医学与健康科学研究院 ENS de Lyon U412 INSERM, France 博士 PhD 1994-09--1997-10 法国里昂大学 Lyon University, France 硕士 Master 1991-09--1994-09 法国第戎大学 Dijon University, France 学士 Bachelor 工作简历 2014-11~现在, 中科院上海巴斯德研究所 Institut Pasteur of Shanghai, CAS, 研究员 Principal investigators 2012-11~2014-11,法国国家科学研究院 CNRS, France, 副教授 Tenure staff scientist position(CNRS CR1) 2011-01~2011-12,牛津大学Glycobiology Institute. Oxford (UK), 访问学者 Visiting scientist 2003-05~2012-11,法国国家医学与健康研究院 INSERM U758, ENS de Lyon, France, 副教授 Tenure staff scientist position(CNRS CR1) 2001-02~2003-05,美国俄勒冈卫生科学大学 OHSU, Portland,USA, 博士后 Post Doc 2000-11~2001-02,美国Mayo医学中心 Mayo Clinic, Minnesota, USA, 项目访问学者 Visiting scientist 奖励信息 (1) 第五批上海“****”引进人才, 一等奖, 省级, 2015 (2) 中国科学院2015年度第二批“****”A类, 院级, 2015 专利成果 ( 1 ) LENTIVIRAL VECTORS PSEUDOTYPED WITH MUTANT BaEV GLYCOPROTEINS, 发明, 2012, 第 3 作者, 专利号: EP2761010 ( 2 ) Procedimiento de detección de la expresión de una proteína de cubierta de un retrovirus endógeno humano y utilizaciones de un gen que codifica para esta proteína, 发明, 2000, 第 4 作者, 专利号: es2444649 ( 3 ) METHOD FOR DETECTING ENVELOPE PROTEIN EXPRESSION OF HUMAN ENDOGENOUS RETROVIRUS, AND USE OF GENE ENCODING THE SAME PROTEIN, 发明, 2008, 第 4 作者, 专利号: JP2009072194 ( 4 ) Method for detecting the expression of an envelope protein of a human endogenous retrovirus and uses of a gene coding for said protein, 发明, 2000, 第 4 作者, 专利号: US7442550 ( 5 ) METHODS FOR IDENTIFYING RECEPTOR UP- AND DOWNMODULATORS, 发明, 2002, 第 4 作者, 专利号: WO2002095400 ( 6 ) METHOD FOR DETECTING THE EXPRESSION OF AN ENVELOPE PROTEIN OF A HUMAN ENDOGENOUS RETROVIRUS AND USES OF A GENE CODING FOR SAID PROTEIN, 发明, 2000, 第 4 作者, 专利号: EP1212359 ( 7 ) METHOD FOR DETECTING THE EXPRESSION OF AN ENVELOPE PROTEIN OF A HUMAN ENDOGENOUS RETROVIRUS AND USES OF A GENE CODING FOR SAID PROTEIN, 发明, 2000, 第 5 作者, 专利号: WO2001016171 ( 8 ) NEW POLYPEPTIDES AND THEIR USE FOR THE RESCUE OF FUSION DEFECTIVE VIRUS OR RETROVIRUS GLYCOPROTEINS, 发明, 2000, 第 3 作者, 专利号: WO2000071578 ( 9 ) USE OF A PROLINE-RICH SEQUENCE TO IMPROVE THE FUSOGENIC CHARACTER OF RETROVIRAL ENVELOPES, 发明, 1999, 第 2 作者, 专利号: CA2317026 ( 10 ) USE OF A PROLINE-RICH SEQUENCE TO IMPROVE THE FUSOGENIC CHARACTER OF RETROVIRAL ENVELOPES, 发明, 1999, 第 2 作者, 专利号: WO1999036561 ( 11 ) CHIMERIC VIRUS -LIKE PARTICLES (VLP) CONTAINING FUNCTIONAL HMPV PROTEINS, 发明, 2013, 第 5 作者, 专利号: WO2013132107 ( 12 ) Chimeric virus-like particles (VLP) containing functional hMPV proteins, 发明, 2012, 第 4 作者, 专利号: EP2636413 ( 13 ) LENTIVIRAL VECTORS PSEUDOTYPED WITH MUTANT BaEV GLYCOPROTEINS, 发明, 2012, 第 3 作者, 专利号: WO2013045639 ( 14 ) Procedimiento de detección de la expresión de una proteína de cubierta de un retrovirus endógeno humano y utilizaciones, 发明, 2012, 第 4 作者, 专利号: es2376726 ( 15 ) Method for detecting the expression of a human endogenous retrovirus envelope protein and uses of a coding gene for said protein, 发明, 2000, 第 4 作者, 专利号: EP2385058 ( 16 ) METHODS FOR ENHANCING THE POTENCY OF HCV NEUTRALIZING ANTIBODIES, 发明, 2000, 第 3 作者, 专利号: WO2006103493 ( 17 ) USE OF A PROLINE-RICH SEQUENCE TO IMPROVE THE FUSOGENIC CHARACTER OF RETROVIRAL ENVELOPES, 发明, 1999, 第 2 作者, 专利号: EP1047791 ( 18 ) LENTIVIRAL VECTORS PSEUDOTYPED WITH MUTANT BaEV GLYCOPROTEINS, 发明, 2012, 第 3 作者, 专利号: US20140235700 ( 19 ) LENTIVIRAL VECTORS PSEUDOTYPED WITH MUTANT BaEV GLYCOPROTEINS, 发明, 2014, 第 3 作者, 专利号: US20140235700 ( 20 ) LENTIVIRAL VECTORS PSEUDOTYPED WITH MUTANT BaEV GLYCOPROTEINS, 发明, 2014, 第 3 作者, 专利号: EP2761010 ( 21 ) Procedimiento de detección de la expresión de una proteína de cubierta de un retrovirus endógeno humano y utilizaciones de un gen que codifica para esta proteína, 发明, 2014, 第 4 作者, 专利号: es2444649 发表著作 (1) 细胞融合:调节和控制 http://www.amazon.cn/Cell-Fusions-Regulation-and-Control/dp/9048197716, Cell Fusions: Regulation and Control .A Comparative Portrait of Retroviral Fusogens and Syncytins. , Springer; 1 , 2010-11, 第 3 作者 (2) HCV进入宿主细胞的机制, The mechanism of HCV entry into host cells. , Progress in Molecular Biology and Translational Science--Elsevier, 2014-12, 第 2 作者 科研项目 ( 1 ) 中国科学院****A类:Virus-host interactions at the cell level, 主持, 部委级, 2016-01--2018-12 ( 2 ) 寨卡病毒感染致病机制及综合防控, 主持, 国家级, 2017-10--2019-12 参与会议 (1)“Interaction between Dengue, Zika and Chikungunya Viruses during Coinfection in Mosquito” 2017-09-26 (2) “The evolution and consequences of Zika virus post translational modifications” 2017-06-16 (3)Zika in China, infection cell entrance and molecular structures 2004年中法防治新发传染病合作协议的指导委员会会议 2016-07-01 (4)Modulation of Zika tropism in insect and mammal cells, Zika 国际Zika 交流会议 2016-06-01 (5)Strong specialization of HCV envelope glycoproteins is associated with the establishment of B-lymphocyte reservoirs in chronically infected patients. 第十四次全国肝炎会仪 F Douam, LM Bobay, G Maurin, J Fresquet, FL Cosset, C Féray et D Lavillette 2014-01-23 (6)Identification of functional networks in E1E2 glycoproteins unveils Hepatitis C virus fusion mechanisms and new therapeutic opportunities. 第五届欧洲国会病毒学会议 F Douam, L Dib, VL Dao Thi, G Maurin, L Schwaller, J Fresquet, D Mompelat, FL Cosset, A Carbone, D Lavillette. 2013-09-11 (7)Cell entry process of in vitro and in vivo produced hepatitis C virus (HCV) 第五届欧洲国会病毒学会议 S.CALATTINI, L.DAO-THI, F. FUSIL, J. MANCIP, D. LAVILLETTE, F.L. COSSET*, M. DREUX* 2013-09-11 (8)Baboon retrovirus envelope pseudotyped LVs allow efficient transduction of progenitor T cells, thymocytes and adult T and B cells. 第五届欧洲国会病毒学会议 Anais GIRARD, Fouzia AMIRACHE, Caroline COSTA, Camille LEVY, Dimitri LAVILLETTE, Didier NEGRE, Francois-Lo?c COSSET and Els VERHOEYEN. 2013-09-11 (9)Association d’approches expérimentales et bioinformatiques pour déterminer le r?le fonctionnel de domaines qui co-évoluent au sein de protéines virales: application aux glycoprotéines d’enveloppe du virus de l’hépatite C. 第十五届全法语病毒会议 F Douam, VL Dao Thi, G Maurin, J Fresquet, D Mompelat, FL Cosset and D Lavillette 2013-04-18 (10)Active role of E1 in the conformation of E1E2 and in the exposition of receptor binding domains. 第十二次全国肝炎会议 Florian Douam, Guillemette Maurin, Judith Fresquet, Fran?ois-Lo?c Cosset and Dimitri Lavillette. 2013-01-24 (11)Prevention from Chikungunya virus experimental infection in macaques by live attenuated and replicating vaccine. 第六届欧洲动物传播病毒会议 Lavillette D, Dereuddre-Bosquet N, Lotteau V, Cosset FL, Roques P, Le Grand R. 2011-10-01 (12)Active role of E1 in the conformation of E1E2 and in the exposition of receptor binding domains. 第十八届丙肝及相关病毒的国际研讨会 F Douam, G Maurin, J Fresquet, FL Cosset and D Lavillette 2011-09-08 (13)Identification of an interaction between the N-terminal and the transmembrane domains of E1 envelope glycoprotein important for HCV cell entry process. Mutations in SR-BI or in HCV-E2 that abrogate SR-BI/H 第十七届丙肝及相关病毒的国际研讨会 Guillemette Maurin, Judith Fresquet, Ophelia Granio, Fran?ois-Lo?c Cosset, Dimitri Lavillette 2010-09-10

研究领域

以虫媒病毒为研究对象,感染哺乳动物细胞和蚊虫,通过体内外实验,揭示病毒致病因子、宿主促病毒因子或者限制性因子。特别关注i)在病毒进入细胞、跨种传播和易感性中发挥重要作用的宿主因子ii)蚊虫体内影响病毒复制和传播的细胞反应和信号通路。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

(1) A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism., PLoS Pathog, 2018, 通讯作者 (2) Chronic infection of mosquito by Chikungunya virus increases its susceptibility to Zika, Dengue and Yellow fever viruses during coinfection., Int.J.Mol.Sci, 2017, 通讯作者 (3) Specialization of hepatitis C virus envelope glycoproteins for B-lymphocytes in chronically infected patients., J Virol., 2016, 通讯作者 (4) New insights into the understanding of hepatitis C virus entry and cell-to-cell transmission by using the ionophore Monensin A, J VIROL (IF2014 4.43), 2015, 通讯作者 (5) The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions., J VIROL (IF2014 4.43), 2015, 通讯作者 (6) Low cross-neutralization of hepatitis C correlates with liver disease in immunocompromized patients, AIDS (IF2013 6.55), 2015, 通讯作者 (7) The mechanism of HCV entry into host cells., PROG MOL BIOL TRANSL SCI. (IF2013 3.11), 2015, 第 2 作者 (8) A Critical Interaction Between E1 and E2 Glycoproteins Determines Binding and Fusion Properties of Hepatitis C Virus During Cell Entry, HEPATOLOGY (IF2012 12.03), 2014, 通讯作者 (9) Baboon envelope pseudotyped lentiviral vectors outperform VSV-G pseudotyped lentiviral vectors for gene transfer into cytokine-stimulated and resting hematopoietic stem cells, BLOOD(IF2012 9), 2014, 通讯作者 (10) The Expression of the Hepatocyte SLAMF3 (CD229) Receptor Enhances the Hepatitis C Virus Infection, PLOS ONE(IF2013 3.53), 2014, 通讯作者 (11) Up-Regulation of the ATP-Binding Cassette Transporter A1 Inhibits Hepatitis C Virus Infection., PLOS ONE(IF2013 3.53), 2014, 通讯作者 (12) Virus-like particle vaccine induces cross-protection against human metapneumovirus infections in mice., VACCINE (IF2011 3.458), 2013, 通讯作者 (13) The antimalarial ferroquine is an inhibitor of hepatitis C virus, HEPATOLOGY (IF2012 12.00), 2013, 通讯作者 (14) Characterization of hepatitis C virus particle sub-populations reveals multiple usage of the scavenger receptor BI for entry steps, J BIOL CHEM (IF2011 5.11), 2012, 通讯作者 (15) Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle. , VOROLOGY (IF2011 3.35), 2012, 通讯作者 (16) Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2. , BIOCHEMICAL JOURNAL (IF2011 4.89), 2012, 通讯作者 (17) A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques., SCIENCE TRANSLATIONAL MEDICINE (IF2010 7.18), 2011, 通讯作者 (18) EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy. , NATURE MEDICINE (IF2010 25.43), 2011, 通讯作者 (19) Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol., PLOS ONE (IF2010 4.41), 2011, 第 4 作者 (20) Cell Entry of Enveloped Viruses, ADVANCES IN GENETICS (IF2011 3.77), 2011, 第 2 作者 (21) Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening, FASEB J. (IF2009 6.40), 2009, 通讯作者 (22) Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus, J VIROL. (IF2006 5.34), 2007, 第 1 作者 (23) Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection, J VIROL. (IF2005 5.1), 2005, 第 1 作者 (24) Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus, HEPATOLOGY (IF2005 9.8), 2005, 第 1 作者

学术兼职

2010-01-01-今,Treasurer and Active Member of the Advisory Council of the European Society for Virology , Treasurer and Active Member 2010-01-01-今,Member of the scientific council of FINOVI foundation , Member of the scientific council

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