余永耀 - 香港理工大学 - 应用生物及化学科技学系

个人简介

Awards Croucher Foundation Postdoctoral Fellowship 1993-1996 Best teaching award in ABCT 2011 ABCT Star Award, PolyU 2014 ABCT Star Award, PolyU 2016 Asian Core Program Lectureship Award (ICCEOCA-8) 2014 (Japan) Asian Core Program Lectureship Award (ICCEOCA-9) 2015 (Taiwan) Asian Core Program Lectureship Award (ICCEOCA-9) 2015 (China)

研究领域

We are aspired is to develop catalytic methods to convert unactivated carbon-hydrogen bonds to carbon-carbon and carbon-heteroatom (e.g. nitrogen) bonds. Our research would bring innovative solutions to conventional synthetic methods for productions of pharmaceutical and functional materials by improving atom- and steps-economy in chemical synthesis. Our current research on the fundamental reactivity of organotransition metal complexes with carboradicals, carbenes and nitrenes has already resulted breakthrough in regioselective catalytic C-H bond cross coupling reactions.

近期论文

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Lee PY, Liang P, Yu WY. Pd(II)-Catalyzed Direct ortho-C-H Acylation of Aromatic Ketones by Oxidative Decarboxylation of α-Oxocarboxylic Acids. Organic Letters. 2017;19(8):2082-5. Chan CM, Zhou Z, Yu WY. Rhodium-Catalyzed Oxidative Cycloaddition of N-tert-Butoxycarbonylhydrazones with Alkynes for the Synthesis of Functionalized Pyrroles via C(sp3)–H Bond Functionalization. Advanced Synthesis and Catalysis. 2016;358(24):4067-74. Lu YS, Yu WY. Cp∗Rh(III)-Catalyzed Cross-Coupling of Alkyltrifluoroborate with α-Diazomalonates for C(sp3)-C(sp3) Bond Formation. Organic Letters. 2016;18(6):1350-3. Ng FN, Lau YF, Zhou Z, Yu WY. [RhIII(Cp*)]-Catalyzed cascade arylation and chlorination of α-diazocarbonyl compounds with arylboronic acids and n -chlorosuccinimide for facile synthesis of α-aryl-α-chloro carbonyl compounds. Organic Letters. 2015;17(7):1676-9. Ng FN, Zhou Z, Yu WY. [RhIII(Cp*)]-catalyzed ortho-selective direct C(sp 2)-H bond amidation/amination of benzoic acids by N-chlorocarbamates and N-chloromorpholines. A versatile synthesis of functionalized anthranilic acids. Chemistry - A European Journal. 2014;20(15):4474-80. Ng KH, Zhou Z, Yu WY. [Cp*RhCl2]2-catalyzed ortho-C-H bond amination of acetophenone o-methyloximes with primary N-chloroalkylamines: Convenient synthesis of N-alkyl-2-acylanilines. Chemical Communications. 2013;49(63):7031-3. Ng KH, Zhou Z, Yu WY. Rhodium(III)-catalyzed intermolecular direct amination of aromatic C-H bonds with N-chloroamines. Organic Letters. 2012;14(1):272-5. Chan WW, Lo SF, Zhou Z, Yu WY. Rh-catalyzed intermolecular carbenoid functionalization of aromatic C-H bonds by α-diazomalonates. Journal of the American Chemical Society. 2012;134(33):13565-8. Ng KH, Ng FN, Yu WY. A convenient synthesis of anthranilic acids by Pd-catalyzed direct intermolecular ortho-C-H amidation of benzoic acids. Chemical Communications. 2012;48(95):11680-2. Ng KH, Chan ASC, Yu WY. Pd-catalyzed intermolecular ortho-C-H amidation of anilides by N-nosyloxycarbamate. Journal of the American Chemical Society. 2010;132(37):12862-4.