Phipps, Simon - University of Queensland - School of Biomedical Sciences

研究领域

Innate immune processes that underlie the pathogenesis of allergic asthma, emphysema and bronchiolitis. Dr. Phipps’ research program employs both in vitro and in vivo model systems to elucidate the relationship between innate pattern recognition receptors (PRR) and the programming of aberrant immunologic processes that underlie the development of distinct endophenotypes of asthma, emphysema and virus-associated bronchiolitis. The group also has an interest in understanding the cellular and molecular mechanisms that contribute to bronchus-associated lymphoid tissue (BALT) formation and the contribution of BALT to host defense.

近期论文

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1.G.E.Kaiko, Z.Loh, K.Spann, A.Lalwani, S.Davidson, Z.Zhang, S.Uematsu, S.Akira, K.Baines, J.L. Simpson, P.S. Foster and S.Phipps. TLR7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice. J.Allergy Clin.Immunol. (2013) 131(5), 1331-9 [Impact Factor: 11.0] By modelling a clinically relevant gene-environment interaction, we have developed a unique and sophisticated mouse model of virus-induced asthma that will accelerate the understanding of pathogenic processes that underlie the pathogenesis of asthma. 2 S.Davidson, G.Kaiko, Z.Loh. A.Lalwani, V.Zhang, K.Spann, S.Y.Foo, N.Hansbro, S.Uematsu, S.Akira, K.I.Matthaei, H.F.Rosenberg, P.S.Foster, S.Phipps. Plasmacytoid Dendritic Cells Promote Host Defense Against Acute Pneumovirus Infection via theTLR7-MyD88-Dependent Signaling Pathway. J. Immunol. (2011) 186(10), 5938-4 [Impact Factor: 5.65] This paper demonstrates that TLR7 expression by pDC promotes the induction of antiviral immunity in early life against low dose infection with the mouse-specific Pneumovirus, Pneumonia virus of mice (PVM). 3.J.Mattes, A.Collison, M.Plank, S.Phipps, P.S.Foster. MicroRNAs Bridge Innate and Adaptive Immunity: Induction of Th2 Mediated Allergic Airways Disease. Proceedings of the National Academy of Sciences (2009) 106(44):18704-9 [Impact Factor: 9.60] This paper was the first to report a role for a micro-RNA in the development of allergen induced Th2 immunity. 4.S.Phipps, C.E.Lam, G.E.Kaiko, A.Foo, A.Collison, J.Mattes, J.Barry, S.Davidson, K.Oreo, L.Smith, A.Mansell, K.I.Matthaei, P.S.Foster. Toll-Interleukin-1 signalling is critical for house dust mite-specific Th2 and Th17 responses. Am. J. Respir. Crit. Care Med. (2009) 179:883-93 [Impact Factor: 10.19] This landmark publication, together with an article by Lambrecht and colleagues published in Nature Medicine (also 2009) demonstrated that house-dust mite-induced Th2 responses were dependent on TLR4 and not TLR2. 5.S.Phipps, C.E.Lam, S.Mahalingam, M.Newhouse, R.Ramirez, H.F.Rosenberg, P.S.Foster, K.I.Matthaei. Eosinophils contribute to innate anti-viral immunity in the lung and promote clearance of respiratory syncytial virus. Blood. (2007) 110: 1578-1586 [Impact Factor: 10.9] This publication challenged the accepted dogma that eosinophils do not protect against virus infections, and demonstrated that eosinophils express functional toll-like receptors. 6.H.F.Rosenberg, S.Phipps, P.S.Foster. Eosinophil Trafficking in Allergy and Asthma. J. Aller. Clin. Immunol. (2007) 119: 1303-10 [Impact Factor: 7.7] This state-of-the-art review article summarised new knowledge surrounding the recruitment and migration of eosinophils. 7.S.Phipps, F.Benyahia, T.Ou, J.Barkans, D.S.Robinson and A.B.Kay. Acute allergen-induced airway remodeling in atopic asthma. Am J Respir Cell Mol.Biol. (2004) 31: 626-632 [Impact Factor: 4.175] This paper demonstrated that features of airway remodelling occur rapidly in response to allergen challenge, debunking the idea that such alterations occur slowly and in response to chronic inflammation. 8.S.Phipps, P.Flood-Page, A.Menzies-Gow, Y.E.Ong, and A.B.Kay. Effect of intravenous administration of an anti-IL-5 monoclonal antibody (mepolizumab) on allergen-induced tissue eosinophils,the late-phase allergic skin reaction and tenascin deposition in human atopic subjects. J. Invest. Dermatol. (2004) 122:1406-1412 [Impact Factor: 4.238] Using a humanised mAb to anti-IL-5 in vivo, this clinical paper demonstrated that eosinophils induce fibroblast tenascin expression during the cutaneous late phase reaction, identifying a new role for eosinophils. 9.P.Flood-Page, A.Menzies-Gow, S.Phipps, S.Ying, A.Wangoo, M.Ludwig, N.Barnes, D.S.Robinson, and A.B.Kay. Anti-IL-5 treatment (mepolizumab) reduces deposition of extracellular matrix proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics: evidence for a role for eosinophils in airways remodeling. J Clin Invest. (2003) 112:1029-36 [Impact Factor: 14.307] This paper definitively showed that eosinophil depletion in man decreases the deposition of matrix proteins at epithelial basement membrane of asthmatics, establishing a new function of eosinophils. 10.S.Phipps, S.Ying, A.Wangoo, Y.E.Ong, F.Levi-Schaffer, and A.B.Kay. The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin. J Immunol. (2002) 169:4604-4612 [Impact Factor: 7.014]