Ngo, Shyuan - University of Queensland - School of Biomedical Sciences

研究领域

My current research focuses on the causes and consequences of metabolic dysfunction in MND. I am particularly interested in identifying which metabolic pathways are disrupted in MND and how targeting these pathways might correct for defective energy balance, and prolong survival in MND. I collaborate with international researchers and neurologists in Paris, Strasbourg, and Utrecht, and with neurologists at the Royal Brisbane & Women’s Hospital with the broader goal of translating basic research in animal and stem cell models of MND to the clinic. In collaboration with leading stem cell biologists in Australian and China, I am also interested in investigating how induced pluripotent stem cells may be used as a therapeutic avenue in MND.

近期论文

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Ioannides, Z. A., Ngo, S. T., Henderson, R. D., McCombe, P. A. and Steyn, F. J. (2016) Altered metabolic homeostasis in amyotrophic lateral sclerosis: mechanisms of energy imbalance and contribution to disease progression. Neurodegenerative Diseases, 15 5-6: 382-397. doi:10.1159/000446502 Ngo, S. T., Steyn, F. J., Huang, L., Mantovani, S., Pfluger, C. M. M., Woodruff, T. M., O'Sullivan, J. D., Henderson, R. D. and McCombe, P. A. (2015) Altered expression of metabolic proteins and adipokines in patients with amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 357 1-2: 22-27. doi:10.1016/j.jns.2015.06.053 Ngo, S. T. and Steyn, F. J. (2015) The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis. Cell Regeneration, 4 5: 1-14. doi:10.1186/s13619-015-0019-6 Palamiuc, Lavinia, Schlagowski, Anna, Ngo, Shyuan T., Vernay, Aurelia, Dirrig-Grosch, Sylvie, Henriques, Alexandre, Boutillier, Anne-Laurence, Zoll, Joffrey, Echaniz-Laguna, Andoni, Loeffler, Jean-Philippe and René, Frédérique (2015) A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis. EMBO Molecular Medicine, 7 5: 526-546. doi:10.15252/emmm.201404433 Ngo, Shyuan T., Steyn, Frederik J., McCombe, Pamela A. and Borges, Karin (2015). High Caloric diets for amyotrophic lateral sclerosis. In Ronald Ross Watson and Victor R. Preedy (Ed.), Bioactive nutraceuticals and dietary supplements in neurological and brain disease: prevention and therapy (pp. 355-361) London, United Kingdom: Academic Press. doi:10.1016/B978-0-12-411462-3.00036-9 Ngo, S. T., Steyn, F. J. and McCombe, P. A. (2014) Gender differences in autoimmune disease. Frontiers in Neuroendocrinology, 35 3: 347-369. doi:10.1016/j.yfrne.2014.04.004 Ngo, S.T., Steyn, F.J. and McCombe, P.A. (2014) Body mass index and dietary intervention: Implications for prognosis of amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 340 1-2: 5-12. doi:10.1016/j.jns.2014.02.035 Steyn, F. J., Lee, Kevin, Fogarty, M. J., Veldhuis, J. D., McCombe, P. A,, Bellingham, M. C., Ngo, S. T. and Chen, C (2013) Growth hormone secretion is correlated with neuromuscular innervation rather than motor neuron number in early-symptomatic male amyotrophic lateral sclerosis mice. Endocrinology, 154 12: 4695-4706. doi:10.1210/en.2013-1570 Steyn, F. J., Xie, T. Y., Huang, L., Ngo, S. T., Veldhuis, J. D., Waters, M. J. and Chen, C. (2013) Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain. Journal of Endocrinology, 218 2: 233-244. doi:10.1530/JOE-13-0084 Ngo, Shyuan T. and Bellingham, Mark C. (2013). Neurophysiological recording of the compound muscle action potential for motor unit number estimation in mice. In Pilowsky, Paul M., Farnham, Melissa M. J. and Fong, Angelina Y. (Ed.), Stimulation and inhibition of neurons (pp. 225-235) New York, NY, United States: Humana Press. doi:10.1007/978-1-62703-233-9_13 Ngo, S. T., Baumann, F., Ridall, P. G., Pettitt, A. N., Henderson, R. D., Bellingham, M. C. and McCombe, P. A. (2012) The relationship between Bayesian motor unit number estimation and histological measurements of motor neurons in wild-type and SOD1(G93A) mice. Clinical Neurophysiology, 123 10: 2080-2091. doi:10.1016/j.clinph.2012.01.028 Ngo, Shyuan T., Cole, Rebecca N., Sunn, Nana, Phillips, William D. and Noakes, Peter G. (2012) Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering through muscle-specific kinase phosphorylation. Journal of Cell Science, 125 6: 1531-1543. doi:10.1242/jcs.095109 Steyn, F. J., Ngo, S. T, Lee, J. D., Leong, J. W., Buckley, A. J., Veldhuis, J. D., McCombe, P. A., Chen, C. and Bellingham, M. C. (2012) Impairments to the GH-IGF-I axis in hSOD1(G93A) mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis. Endocrinology, 153 8: 3735-3746. doi:10.1210/en.2011-2171 Muttenthaler, Marcus, Nevin, Simon T., Grishin, Anton A., Ngo, Shyuan T., Choy, Peng T., Daly, Norelle L., Hu, Shu-Hong, Armishaw, Christopher J., Wang, Ching-I. A., Lewis, Richard J., Martin, Jennifer L., Noakes, Peter G., Craik, David J., Adams, David J. and Alewood, Paul F. (2010) Solving the alpha-conotoxin folding problem: Efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antaqonists. Journal of the American Chemical Society, 132 10: 3514-3522. doi:10.1021/ja910602h Chen, F, Qian, L, Yang, ZH, Huang, Y, Ngo, ST, Ruan, NJ, Wang, J, Schneider, C, Noakes, PG, Ding, YQ, Mei, L and Luo, ZG (2007) Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction. Neuron, 55 2: 247-260. doi:10.1016/j.neuron.2007.06.031