Lavidis, Nicholas - University of Queensland - School of Biomedical Sciences

研究领域

The nervous system is highly adaptive to environmental influences. This is because the nervous system has enormous reserves that it can draw upon when stimulated appropriately. Sometimes such up regulation is advantages but many times these changes are detrimental. Dr Lavidis has for 26 years examined these changes and endeavoured to understand the mechanisms responsible for such up regulation. Dr Lavidis is currently examining the effect of stress on the nervous and immune system. He and his team of 9 PhD students in association with a number of academics within the School of Biomedical Sciences at The University of Queensland and the Department of Pharmacology at The University of Sydney are examining the effects of plant derived odours in ameliorating the effects of chronic stress. In collaboration with A/Prof. Noakes, we are examining the importance of adhesion molecules in synaptic formation. In collaboration with A/Prof. Meunier we are examining the mechanisms of synaptic vesicle recycling. In collaboration with Prof. Franklin, he is examining the neuro-protective mechanisms that allow an animal to hibernate or aestivate for years without adverse effects. In collaboration with Dr Moritz and Dr Burne, we are examining the effects of low chronic doses of alcohol on the hippocampus and behaviour. In collaboration with A/Prof. Sernia, we are examining the effect of stress on reactive oxygen species production and how plant derived odours may reduce such oxidative stress. In collaboration with Dr Borges we are examining the link between epilepsy and stress.

近期论文

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Knight, D., Mann, D.J., Jackson, V.M., Trout, S.J., Cunnane, T.C. and Lavidis, N.A. Correlation of non-uniform protein expression with variation in transmitter release probability. Synapse. 2005. 55:110-21. Husdon, N.J. Lavidis, N.A. Choy, P.T. and Franklin, C.E. Effect of prolonged inactivity on skeletal motor nerve terminals during aestivation in the burrowing frog, Cyclorana alboguttata. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2005. 191:373-37. Schenning, M., Proctor, D.T., Ragnarsson, L., Barbier J., Lavidis N.A., Molgo, J.J., Zamponi, G.W., Schiavo, G., and Meunier, F.A. Glycerotoxin stimulates neurotransmitter release from N-type Ca2+ channel expressing neurons. J Neurochem. 2006. 98(3):894-904. O’Leary, D.A., Noakes, P.G., Lavidis, N.A., Kola, I., Hertzog, P.J., and Ristevski, S. (2006) Targeting of the ETS factor Gapba disrupts neuromuscular junction synaptic function. Mol. Cell Biol. 27:3470-80. St Pierre L, Fischer H, Adams DJ, Schenning M, Lavidis N, de Jersey J, Masci PP, Lavin MF. (2007) Distinct activities of novel neurotoxins from Australian venomous snakes for nicotinic acetylcholine receptors. Cell Mol Life Sci. 64:2829-40. Lavidis NA, Hudson NJ, Choy PT, Lehnert SA, Franklin CE. (2008) Role of calcium and vesicle docking proteins in remobilising dormant neuromuscular junctions in desert frogs. J Comp Physiol A Neuroethol Sens Neural Behav Physiol.194:27-37 Meunier FA, Nguyen TH, Colasante C, Luo F, Sullivan RK, Lavidis NA, Molgó J, Meriney SD, Schiavo G. (2010) Sustained synaptic-vesicle recycling by bulk endocytosis contributes to the maintenance of high-rate neurotransmitter release stimulated by glycerotoxin. J Cell Sci. 123(Pt 7):1131-40