唐云平 - 浙江海洋大学 - 食品与医药学院

个人简介

2003.09-2007.06 浙江工商大学生物工程本科 2007.09-2010.06 浙江工商大学生物化工硕士 2011.09-2016.06 浙江大学生物化工博士 2016.09-至今任教于浙江海洋大学食品与医药学院药学系、浙江省海洋生物医用制品工程技术研究中心 2018.08-至今浙江工业大学-长兴制药有限公司生物化工博士后教学情况承担本科生课程《制药工艺学》、《蛋白质与酶工程》指导本科生毕业设计和课程设计指导国家级大学生创新创业训练计划项目1项指导浙江省大学生新苗人才计划1项科研项目 [1] 国家青年自然科学基金，基于MAPK/NF-κB和PI3K/Akt/NF-κB信号通路的海洋多肽CSP免疫调节机制研究，项目编号NO.41806153，2019.1.1-2021.12.31，课题主持人。 [2] 浙江省博士后择优项目，羰基还原酶的挖掘及催化制备氯醇类化合物的关键技术，2019.06-2022.06，课题主持人 [3] 企业横向课题，羰基还原酶的挖掘及催化制备氯醇类化合物的关键技术，长兴制药股份有限公司，2017.09-2019.12，课题主持人。

研究领域

海洋生物活性物质的功能研究：免疫调节和护肝、羰基还原酶催化制备关键手性药物中间体

近期论文

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(1) YafengZhou, QiaojunZhao, ShuyaoZhou, FandiQue, GuifangLi, and YunpingTang*. Efficient biosynthesis of (R)-2-chloro-1-(2, 4-dichlorophenyl) ethanol using a mutant short-chain dehydrogenase from Novosphingobium aromaticivorans. Tetrahedron Letters, 2020, https:// doi.org/10.1016/j.tetlet.2020.151914. (2019 IF 2.259, 中科院分区三区). (2) Fangmiao Yu*, Kang He, Xiaoze Dong, Zhuangwei Zhang, Fenglei Wang, Yunping Tang*, Yan Chen, Guofang Ding. Immunomodulatory activity of low molecular-weight peptides from Nibea japonica skin in cyclophosphamide-induced immunosuppressed mice. Journal of Functional Foods, 2020, 68: 103888. (2019 IF 3.197, 中科院分区二区). (3) Xiaoxia Jiang, Yafeng Zhou, Yun Zhang*, Diying Tian, Su Jiang, YunpingTang*. Hepatoprotective effect of pyrroloquinoline quinone against alcoholic liver injury through activating Nrf2-mediated antioxidant and inhibiting TLR4-mediated inflammation responses. Process Biochemistry, 2020, 92: 303-312. (2019 IF 2.883, 中科院分区三区). (4) Yunping Tang*, Yafeng Zhou, Qiaojun Zhao, Qiaoling Zhao, Zhao Wang*. Enzymatic synthesis of an orlistat intermediate using a mutant short-chain dehydrogenase from Novosphingobium aromaticivorans. Process Biochemistry, 2020, https://doi.org/10.1016/j.procbio.2020.02.015. (2019 IF 2.883, 中科院分区三区). (5) Yingyue Chen, Huoxi Jin, Fei Yang, Shujie Jin, Chenjuan Liu, Liukai Zhang, Ju Huang, Shiguang Wang, Zhongyong Yan, Xuwei Cai, Rui Zhao, Fangmiao Yu, Zuisu Yang, Guofang Ding, Yunping Tang*. Physicochemical, antioxidant properties of giant croaker (Nibea japonica) swim bladders collagen and wound healing evaluation. International Journal of Biological Macromolecules, 2019, 138: 483-491. (2019 IF 4.784, 中科院分区二区, TOP). (6) Nan Chen, Yinyue Chen, Yunping Tang*, Qiaoling Zhao, Chenjuan Liu, Wenwen Niu, Peiyang Huang, Fangmiao Yu, Zuisu Yang, Guofang Ding. Efficient synthesis of (S)-2-chloro-1-(2, 4-dichlorophenyl) ethanol using a tetrad mutant alcohol dehydrogenase from Lactobacillus kefir, Process Biochemistry, 2019, 85:78-83. (2019 IF 2.883, 中科院分区三区). (7) Chuhong Zong, Xu Zhang, Fei Yang, Yafeng Zhou, Nan Chen, Zuisu Yang, Guofang Ding, Fangmiao Yu* and Yunping Tang*. Biotransformation of a Crizotinib intermediate using a mutant alcohol dehydrogenase of Lactobacillus kefir coupled with glucose dehydrogenase. Preparative Biochemistry & Biotechnology 2019, 49(6):578-583. (2019 IF 1.117, 中科院分区四区). (8) Xiaoxia Jiang, Fei Yang, Qiaojun Zhao, Diying Tian, Yunping Tang*. Protective effects of pentadecapeptide derived from Cyclaina sinensis against cyclophosphamide-induced hepatotoxicity. Biochemical and Biophysical Research Communications, 2019, 520(2):392-398. (2019 IF 2.705, 中科院分区三区). (9) Fei Yang, Shujie Jin, Yunping Tang*. Marine Collagen Peptides Promote Cell Proliferation of NIH-3T3 Fibroblasts via NF-κB Signaling Pathway. Molecules, 2019, 24(22), 4201. (2019 IF3.06, 中科院分区三区). (10) Fangmiao Yu*, Zhuangwei Zhang, Shengwang Ye, Xiaoxia Hong, Huoxi Jin, Fangfang Huang, Zuisu Yang, Yunping Tang*, Yan Chen, Guofang Ding. Immunoenhancement effects of pentadecapeptide derived from Cyclina sinensis on immune-deficient mice induced by Cyclophosphamide. Journal of Functional Foods, 2019 (60):103408. (2019 IF 3.197, 中科院分区二区). (11) Shuoqi Jiang, Yinglu Jia, Yunping Tang*, Die Zheng, Xingbiao Han, Fangmiao Yu, Yan Chen, Fangfang Huang, Zuisu Yang and Guofang Ding*. Anti-Proliferation activity of a decapeptide from Perinereies aibuhitensis toward human lung cancer H1299 cells. Marine Drugs 2019, 17(2), 122. (2019 IF 3.772, 中科院分区二区). (12) Yanan Chen, Yunping Tang*, Yanhua Tang, Zuisu Yang and Guofang Ding*. Serine protease from Nereis virens inhibits H1299 lung cancer cell proliferation via the PI3K/AKT/mTOR pathway. Marine Drugs 2019, 17(6), 366. (2019 IF 3.772, 中科院分区二区). (13) Xinhui Lin, Yinyue Chen, Huoxi Jin, Qiaoling Zhao, Chenjuan Liu, Renwei Li, Fangmiao Yu, Yan Chen*, Fangfang Huang, Zuisu Yang, Guofang Ding and Yunping Tang*. Collagen extracted from bigeye tuna (Thunnus obesus) skin by isoelectric precipitation: physicochemical properties, proliferation, and migration activities. Marine Drugs, 2019, 17, 261. (2019 IF 3.772, 中科院分区二区). (14) Wei Li, Shengwang Ye, Zhuangwei Zhang, Jiachao Tang, Huoxi Jin, Fangfang Huang, Zuisu Yang, Yunping Tang*, Yan Chen, Guofang Ding and Fangmiao Yu*. Purification and characterization of a novel pentadecapeptide from protein hydrolysates of Cyclina sinensis and its immunomodulatory effects on RAW264.7 cells. Marine Drugs, 2019, 17, 30-45. (2019 IF 3.772, 中科院分区二区). (15) Yunping Tang, Shujie Jin, Xiaoyan Li, Xiaojuan Li, Xuyang Hu, Yan Chen, Fangfang Huang, Zuisu Yang, Fangmiao Yu* and Guofang Ding*. Physicochemical properties and biocompatibility evaluation of collagen from the skin of giant croaker (Nibea japonica). Marine Drugs, 2018, 16, 222-232. (2018 IF 4.379, 中科院分区二区). (16) Xiaojuan Li, Yunping Tang*, Fangmiao Yu, Yu Sun, Fangfang Huang, Yan Chen, Zuisu Yang and Guofang Ding*. Inhibition of prostate cancer DU-145 cells proliferation by Anthopleura anjunae oligopeptide (YVPGP) via PI3K/AKT/mTOR signaling pathway. Marine Drugs, 2018, 16, 325-340. (2018 IF 4.379, 中科院分区二区). (17) Fangmiao Yu, Chuhong Zong, Shujie Jin, Jiawen Zheng, Nan Chen, Ju Huang, Yan Chen, Fangfang Huang, Zuisu Yang, Yunping Tang* and Guofang Ding, Optimization of extraction conditions and characterization of pepsin-solubilised collagen from skin of giant croaker (Nibea japonica). Marine Drugs, 2018, 16, 29-40. (2018 IF 4.379, 中科院分区二区). (18) Yunping Tang*, Guomei Zhang, Zheng Wang, Dan Liu, Linglu Zhang, Yafeng Zhou, Ju Huang, Fangmiao Yu, Zuisu Yang and Guofang Ding*, Efficient synthesis of a (S)-fluoxetine intermediate using carbonyl reductase coupled with glucose dehydrogenase. Bioresource Technology, 2018, 250: 457-463. (2018 IF: 5.807, 中科院分区一区, Top). (19) Yunping Tang, Fangmiao Yu, Guomei Zhang, Zuisu Yang, Fangfang Huang, Guofang Ding*, A purified serine protease from Nereis virens and its impaction of apoptosis on human lung cancer cells. Molecules, 2017, 22, 1123-1138. (2017 IF 2.9, 中科院分区三区). (20) Yunping Tang, Xiuliang Yang, Baojian Hang, Jiangtao Li, Lei Huang, Feng Huang, Zhinan Xu*, Efficient production of hydroxylated human like collagen via the co-expression of three key genes in E. coli Origami (DE3). Applied Biochemistry and Biotechnology, 2016, 178, 1458-1470. (2016 IF 1.751, 中科院分区三区).