Gruber, Christian - University of Queensland - School of Biomedical Sciences

研究领域

Laboratory of Chemical Pharmacology The research interest of my team is to study molecular mechanisms in living organisms by employing a toolbox of nature-derived and synthetically optimized compounds with biological activity to be analyzed in vitro and in vivo. This includes the isolation, analysis, design and synthesis of biologically active peptides which will be useful for drug discovery or as diagnostic tools. Currently we study the biological function and pharmacological mechanism of peptides isolated from plants and invertebrates (e.g., peptide hormones, neuropeptides and peptide toxins), and the development of novel peptide therapeutics.

近期论文

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Koehbach J, O’Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, Freissmuth M, Gruber CW (2013) Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America 110: 21183-8. Gruber CW, Elliott AG, Ireland DC, Delprete PG, Dessein S, Göransson U, Trabi M, Wang CK, Kinghorn AB, Robbrecht E, Craik DJ (2008) Distribution and Evolution of Circular Miniproteins in Flowering Plants. Plant Cell 20: 2471-83. Gruber CW, Muttenthaler M (2012) Discovery of defense- and neuropeptides in social ants by genome-mining. Public Library of Science ONE 7(3): e32559. Gruber CW, Wang CK, Cemazar M, Siatskas C, Tagore P, Payne N, Sun G, Wang S, Bernard CC, Craik DJ (2014) Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chemical Biology, 9: 156-63. Gruber CW (2014) Physiology of invertebrate oxytocin and vasopressin neuropeptides. Experimental Physiology 99: 55-61.