Clark, Richard - University of Queensland - School of Biomedical Sciences

研究领域

The role of bioactive peptides in human disease We are interested in studying the role of naturally occurring bioactive peptide in a broad range of human diseases. Peptides have a diverse range of functions in human biology including acting as hormones, neuro-regulators and in the protection against pathogens. Our work in this area is focused on understanding the molecular mechanism that these peptide use to elicit a biological response with the hope of using this knowledge to develop new drug leads. Peptide-based drug design The study of endogenous human peptides and proteins and the isolation and characterisation of bioactive peptides from natural sources has generated huge interest in the development of these molecules for the treatment of a broad range of human diseases. Although there are many advantages of using peptides as therapeutics, there are still a number of hurdles that need to be overcome before this source of promising drug leads fulfil their vast potential. Our goal is to create potent and selective drug leads based on naturally occurring peptides for the treatment of human diseases and to develop novel strategies to provide these molecules with the ability to resist the body’s natural degradation pathways so they are able to reach their biological target.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Kompella, Shiva N., Hung, Andrew, Clark, Richard J., Mari, Frank and Adams, David J. (2015) Alanine scan ofα-conotoxin regIIA reveals a selective α3β4 nicotinic acetylcholine receptor antagonist. Journal of Biological Chemistry, 290 2: 1039-1048. doi:10.1074/jbc.M114.605592 Berecki, Géza, McArthur, Jeffrey R., Cuny, Hartmut, Clark, Richard J. and Adams, David J. (2014) Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation. Journal of General Physiology, 143 4: 465-479. doi:10.1085/jgp.201311104 Clark, Richard J., Tan, Chia Chia, Preza, Gloria C., Nemeth, Elizabeta, Ganz, Tomas and Craik, David J. (2011) Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chemistry and Biology, 18 3: 336-343. doi:10.1016/j.chembiol.2010.12.009 Henriques, Sonia Troeira, Tan, Chia Chia, Craik, David J. and Clark, Richard J. (2010) Structural and functional analysis of human liver-expressed antimicrobial peptide 2. ChemBioChem, 11 15: 2148-2157. doi:10.1002/cbic.201000400 Clark, Richard J., Jensen, Jonas, Nevin, Simon T., Callaghan, Brid P., Adams, David J. and Craik, David J. (2010) The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angewandte Chemie (International Edition), 49 37: 6545-6548. doi:10.1002/anie.201000620