Chen, Chen - University of Queensland - School of Biomedical Sciences

研究领域

The Chen laboratory focuses on the link of cell biological properties and functions. Functions of cells may be the secretion of hormones in endocrine cells, contraction and dilation of cardiomyocytes, or proliferation and apoptosis of cancer cells. Endocrine hormones are key elements regulating cell functions and also depending on normal cell functions to maintain a normal profile of every hormone. We concentrate on hormones, which are important in controlling growth, development, metabolic balance, body mass composition, ageing process, and the plasma glucose levels, such as growth hormone, leptin, orexin, insulin, glucagon, and other adipocyte-derived hormones and factors. Several endogenous and synthetic regulatory peptides have been tested for their regulatory roles in neuroendocrine pituitary and peripheral pancreatic islet endocrine cells on the membrane ion channel kinetics, exocytosis / endocytosis, key molecule expression and synthesis, and receptor expression. The long-term goal of these researches is to find effective way to therapeutically correct growth hormone and insulin deficiency in treating obesity and diabetes. In addition, possible paracrine or autocrine effect of a newly discovered hormone, Ghrelin, in the regulation of uterine endometrial cancer development, is under the investigation in this laboratory. We also investigate the function of cardiomyocytes in chronic heart failure, atrial fibrillation, ischemic cardiomyopathy and diabetic cardiomyopathy. The laboratory is using cutting edge techniques in single cell research, including patch clamping, single cell exocytosis measurement, cell image analysis, single cell shortening (contraction), and super-sensitive hormone assay methods. Modern molecular biology techniques are also employed in the laboratory for different projects, including GFP-transgenic mouse, shRNA-gene knock down using virus transfection, and real-time PCR. One recent development of this lab in supersensitive hormone assay has clarified growth hormone pulsatile profile in mouse, which leads to a series of work on regulation of this hormone profiles using transgenic mouse models.

近期论文

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Cheng, Feifei, Zhao, Lu, Wu, Yuanyuan, Huang, Tiantian, Yang, Gangyi, Zhang, Zhanyu, Wu, Yijia, Jia, Fang, Wu, Jinlin, Chen, Chen and Liu, Dongfang (2016) Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment. Clinical Endocrinology, 84 3: 386-393. doi:10.1111/cen.12950 Zhang, Yibei, Qiao, Haiou, Chen, Chen, Wang, Zhilun and Xia, Xiaodong (2016) Determination of nitrofurans metabolites residues in aquatic products by ultra-performance liquid chromatography-tandem mass spectrometry. Food Chemistry, 192 612-617. doi:10.1016/j.foodchem.2015.07.035 Xie, T. Y., Ngo, S. T., Veldhuis, J. D., Jeffery, P. L., Chopin, L. K., Tschop, M., Waters, M. J., Tolle, V., Epelbaum, J., Chen, C. and Steyn, F. J. (2015) Effect of deletion of ghrelin-o-acyltransferase on the pulsatile release of growth hormone in mice. Journal of Neuroendocrinology, 27 12: 872-886. doi:10.1111/jne.12327 Lv, Lixia, Chen, Hewen, Sun, Jiaying, Lu, Di, Chen, Chen and Liu, Dongfang (2015) PRMT1 promotes glucose toxicity-induced β cell dysfunction by regulating the nucleo-cytoplasmic trafficking of PDX-1 in a FOXO1-dependent manner in INS-1 cells. Endocrine, 49 3: 669-682. doi:10.1007/s12020-015-0543-8 Carrasco-Pozo, Catalina, Gotteland, Martin, Castillo, Rodrigo L. and Chen, Chen (2015) 3,4-dihydroxyphenylacetic acid, a microbiota-derived metabolite of quercetin, protects against pancreatic β-cells dysfunction induced by high cholesterol. Experimental Cell Research, 334 2: 270-282. doi:10.1016/j.yexcr.2015.03.021 Mosa, Rasha Mofeed Habeeb, Zhang, Zhen, Shao, Renfu, Deng, Chao, Chen, Jiezhong and Chen, Chen (2015) Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases. Endocrine, 49 2: 307-323. doi:10.1007/s12020-015-0531-z Yi K.J., So K.H., Hata Y., Suzuki Y., Kato D., Watanabe K., Aso H., Kasahara Y., Nishimori K., Chen, Chen, Katoh K. and Roh S.G. (2015) The regulation of oxytocin receptor gene expression during adipogenesis. Journal of Neuroendocrinology, 27 5: 335-342. doi:10.1111/jne.12268 Chen, Jiezhong, Gu, Wenyi, Yang, Lei, Chen, Chen, Shao, Renfu, Xu, Kewei and Xu, Zhi Ping (2015) Nanotechnology in the management of cervical cancer. Reviews in Medical Virology, 25 S1: 72-83. doi:10.1002/rmv.1825 Guillou, Anne, Romano, Nicola, Steyn, Frederik, Abitbol, Karine, Le Tissier, Paul, Bonnefont, Xavier, Chen, Chen, Mollard, Patrice and Martin, Agnès O. (2015) Assessment of lactotroph axis functionality in mice: longitudinal monitoring of PRL secretion by ultrasensitive-ELISA. Endocrinology, 1-7. doi:10.1210/en.2014-1571 Chen, Jiezhong, Shao, Renfu and Chen, Chen (2015) Possible therapeutic implication of PDL-1/PD-1 axis in endometrial cancer. Journal of Solid Tumors, 5 1: 10-17. doi:10.5430/jst.v5n1p10 Huang, Lili, Tan, Hwee Y., Fogarty, Matthew J., Andrews, Zane B., Veldhuis, Johannes D., Herzog, Herbert, Steyn, Frederik J. and Chen, Chen (2014) Actions of NPY, and its Y1 and Y2 receptors on pulsatile growth hormone secretion during the fed and fasted state. Journal of Neuroscience, 34 49: 16309-16319. doi:10.1523/JNEUROSCI.4622-13.2014 Chen, Chen, Chen, Jiezhong and Zhao, Kong-Nan (2014) Signalling pathways in anti-cancer drug resistance. Current Medicinal Chemistry, 21 26: 3007-3008. Li, Shengbin, Li, Bo, Cheng, Cheng, Xiong, Zijun, Liu, Qingbo, Lai, Jianghua, Carey, Hannah V., Zhang, Qiong, Zheng, Haibo, Zheng, Haibo, Wei, Shuguang, Zhang, Hongbo, Chang, Liao, Liu, Shiping, Zhang, Shanxin, Yu, Bing, Zeng, Xiaofan, Huo, Yong, Nie, Wenhui, Guo, Youmin, Chen, Teng, Han, Jiuqiang, Wang, Jian, Wang, Jun, Chen, Chen, Liu, Jiankang, Stambrook, Peter J., Xu, Ming, Zhang, Guojie, Gilbert, Thomas P., Yang, Huanming, Jarvis, Erich D., Yu, Jun and Yan, Jianqun (2014) Genomic signatures of near-extinction and rebirth of the crested ibis and other endangered bird species. Genome Biology, 15 557: 1-16. doi:10.1186/s13059-014-0557-1 Chen, Jiezhong, Zhao, Kong-Nan and Chen, Chen (2014) The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis. Annals of Translational Medicine, 2 1: . doi:10.3978/j.issn.2305-5839.2013.03.02