Bellingham, Mark - University of Queensland - School of Biomedical Sciences

研究领域

Electrophysiology of synaptic transmission, ion currents and central pattern generation in CNS neurones Current research focuses on the electrophysiology of central nervous system neurones using various in vitro slice preparations, patch clamp techniques, imaging, molecular biology and computer modelling. Projects include - Synaptic transmission: - Electrophysiology of neurotransmitter receptors and ion channels in motor neurons and other central neurons - Real time PCR and single cell RT-PCR to determine neurotransmitter receptor and ion channel subunits - Developmental changes in and mechanisms of short and long term synaptic plasticity - Using RNA interference molecules to block neurotransmitter receptors or ion channels during in vivo (with Prof. Martha Constantine-Paton, MIT) Neurotransmitter receptors and ion currents in CNS neurones: - Differences in neurotransmitter receptor and ion channel types in the neuromotor control system potential role in motor neurone death or survival in an animal model of motor neurone disease (with Assoc Prof. Peter Noakes, Dr Shyuan Ngo and Prof. Martha Constantine-Paton MIT) - Estimation of motor unit number and motor neuron survival in motor neuron disease (with Dr. Pamela McCombe and Rob Henderson at Centre of Clinical Research) - Cholinergic receptor modulation of motor neurones - neuropharmacology and second messenger systems, roles in neurodegerative disease - Effects of anaethetic agents on motor neuron excitability Rhythmic control of movements: - Role of glycine and GABA A receptors in programmed cell death of motor neurones and rhythmic movements in normal and transgenic knockout mice (with Dr. Peter Noakes, SBMS UQ) - Studies of ion currents controlling rhythm generation and computer models of single neurones and rhythmic networks

近期论文

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Kanjhan, Refik, Fogarty, Matthew J., Noakes, Peter G. and Bellingham, Mark C. (2015) Developmental changes in the morphology of mouse hypoglossal motor neurons. Brain Structure and Function, 1-32. doi:10.1007/s00429-015-1130-8 Fogarty, Matthew J., Noakes, Peter G. and Bellingham, Mark C. (2015) Motor cortex layer V pyramidal neurons exhibit dendritic regression, spine loss, and increased synaptic excitation in the presymptomatic hSOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroscience, 35 2: 643-647. doi:10.1523/JNEUROSCI.3483-14.2015 Fogarty, Matthew J., Yanagawa, Yuchio, Obata, Kunihiko, Bellingham, Mark C. and Noakes, Peter G. (2013) Genetic absence of the vesicular inhibitory amino acid transporter differentially regulates respiratory and locomotor motor neuron development. Brain Structure and Function, Online First 1-16. doi:10.1007/s00429-013-0673-9 Bellingham, Mark C. (2013) Pre- and postsynaptic mechanisms underlying inhibition of hypoglossal motor neuron excitability by riluzole. Journal of Neurophysiology, 110 5: 1047-1061. doi:10.1152/jn.00587.2012 Ireland, Matthew F., Funk, Gregory D. and Bellingham, Mark C. (2012) Muscarinic acetylcholine receptors enhance neonatal mouse hypoglossal motoneuron excitability in vitro. Journal of Applied Physiology, 113 7: 1024-1039. doi:10.1152/japplphysiol.00699.2011 Bellingham, Mark C. (2011) A review of the neural mechanisms of action and clinical efficiency of Riluzole in treating Amyotrophic Lateral Sclerosis: What have we learned in the last decade?. CNS Neuroscience and Therapeutics, 17 1: 4-31. doi:10.1111/j.1755-5949.2009.00116.x van Zundert, B., Peuscher, M. H., Hynynen, M., Chen, A., Neve, R. L., Brown, R. H., Constantine-Paton, M. and Bellingham, M. C. (2008) Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis. Journal of Neuroscience, 28 43: 10864-10874. doi:10.1523/JNEUROSCI.1340-08.2008 Banks, GB, Kanjhan, R, Wiese, S, Kneussel, M, Wong, LM, O'Sullivan, G, Sendtner, M, Bellingham, MC, Betz, H and Noakes, PG (2005) Glycinergic and GABAergic synaptic activity differentially regulate motoneuron survival and skeletal muscle innervation. Journal of Neuroscience, 25 5: 1249-1259. doi:10.1523/JNEUROSCI.1786-04.2005