向志明 - 中国科学院大学

个人简介

招生专业 085238-生物工程 070703-海洋生物学招生方向细胞凋亡与免疫学，发育生物学，再生生物学，发酵工程教育背景 2006-09--2010-06 中山大学博士 2003-09--2006-06 湖南师范大学硕士 1998-09--2002-06 湖南农业大学学士专利申报 1、向志明，瞿符发，肖述，喻子牛。一种血清淀粉样蛋白A及其编码基因和应用，国家发明专利, 专利号: ZL 201410084163.2 2、向志明，瞿符发，喻子牛。一种纤维胶凝蛋白及其编码基因和应用，国家发明专利, 专利号: 201410137128.2 项目基金 1. 主持科研项目： 1、国家自然科学青年基金：香港巨牡蛎Fas 信号通路在诱导细胞凋亡和免疫防御中的功能研究，（No.31202021，2013-2015），24万，结题。 2、广东省海洋渔业科技推广专项：海洋生物抗菌肽制备的关键技术攻关，（A201301B08，2013-2015），30万，结题。 3、国家自然科学面上基金：逆境胁迫下香港牡蛎DNA损伤与线粒体凋亡途径的活化机制, （No. 31572661，2016-2019），71.3万，在研。 4、广州市自然科学基金：香港巨牡蛎凋亡标志性基因Caspase-3 的功能分析与应用，（ 2017-2020），20万，在研。 2. 参与部分科研项目： 1、国家农业领域973项目：贝类抗病和抗逆的关键基因及其网络调控机制（2010CB126404）2010-14，487万； 2、国家-广东联合基金项目：近江牡蛎广盐高温耐受/适应性及高效生物矿化的基因资源发掘与分子调控研究（U1201215 2013-16，218万； 3、科技部863项目子课题：牡蛎全基因组选育技术及新品种培育（2012AA10A405）2012-15，83万； 4、中国科学院科技服务网络计划（STS计划）海产品精深加工相关技术与对虾种业技术研发与产业化示范，2016-18，240万； 5、中国科学院A类战略性先导科技专项，生物种群的恢复与重建技术研发2016-19，1000万。

研究领域

主要研究无脊椎动物在病理胁迫下的先天性免疫、细胞凋亡、以及个体胚胎发育以及器官再生等生理现象，并揭示在此过程中相关分子的调控功能；在国内、外刊物上发表学术论文50余篇，其中在国际知名SCI 论文40余篇；申请并公开专利多项；先后主持国家自然基金青年项目1 项，省部属基金2项，国家自然基金面上项目1 项；参加973 研究项目、广东-国家联合基金和海洋先导专项等课题多项；担任国家自然科学基金委评审委员，以及Cellular & Molecular Biology Letters, Fish & Shellfish Immunology 等国际学术期刊审稿人；同时在生态调查研究方面也做了一些相关的工作，在国南海沙群岛的多个岛屿进行了长期的生物学资源的调查，为国家生物资源的可持续性发展提供了材料。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. XiangZM, Qi L, Chen W, Dong C, Liu Z, Liu D, He JG*. Characterization of a TnMAVS protein from Tetraodon nigroviridis. Dev Comp Immunol. 2011 35:1103-15. 2. XiangZM, Dong C, Qi L, Chen W, Huang L, Li Z, He JG*. Characteristics of the interferon regulatory factor pairs zfIRF5/7 and their stimulation expression by ISKNV Infection in zebrafish (Danio rerio). Dev Comp Immunol. 2010 34:1263-73. 3. XiangZM, Yuan W, Luo N, Wang Y, Tan K, Deng Y,Liu MY,Wu XS*. A novel human zinc finger protein ZNF540 interacts with MVP and inhibits transcriptional activities of the ERK signal pathway. Biochem Biophys Res Commun. 2006 347:288-96. 4. XiangZM, Qu F, Qi L, Zhang Y, Xiao S, Yu ZN*. A novel ortholog of serum response factor (SRF) with immune defense function identified in Crassostrea hongkongensis. Fish Shellfish Immunol. 2014 36:75-82. 5. XiangZM, Qu F, Li J, Qi L, Yang Z, Kong X, Yu ZN*. Activator protein-1 (AP-1) and response to pathogen infection in the Hong Kong oyster (Crassostrea hongkongensis). Fish Shellfish Immunol. 2014 36:83-9. 6. XiangZM, Qu F, Qi L, Zhang Y, Tong Y, Yu ZN*. Cloning, characterization and expression analysis of a caspase-8 like gene from the Hong Kong oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 2013 35:1797-803. 7. XiangZM, Qu F, Qi L, Ying T, Li J, Shu X, Yu ZN*. Cloning and characterization of an apoptosis-related DNA fragmentation factor (DFF) from oyster, Crassostrea hongkongensis. Fish Shellfish Immunol. 2014, 38:119-126. 8. XiangZM, Weng S, Qi H, He JG*, Dong C*. Identification and characterization of a novel FstK-like protein from spotted knifejaw iridovirus (genus Megalocytivirus). Gene. 2014 545:233-40. 9. XiangZM, Qu F, Wang F, Li J, Zhang Y, Yu Z*. Characteristic and functional analysis of a ficolin-like protein from the oyster Crassostrea hongkongensis. Fish Shellfish Immunol. 2014 40:514-23. 10. XiangZM, Qu FF, Wang FF, Shu X, Li J , Zhang Y, Yu ZN*. ChBax/Bak as key regulators of the mitochondrial 1 apoptotic pathway:cloned and characterized in Crassostrea hongkongensis. Fish Shellfish Immunol. 2014, 42: 225-232. 11. XiangZM, Xiao S, Wang F, Qin Y, Wu J, Ma H, Yu ZN*. Cloning, characterization and comparative analysis of four death receptorTNFRs from the oyster Crassostrea hongkongensis. Fish Shellfish Immunol. 2016 59:288-97. 12. Qi L, XiangZM*. Molecular cloning and expression analysis of an apoptosis-associated gene Daxx from zebrafish, Danio rerio. Fish Shellfish Immunol. 2015, 45, 59-66. 13. Wang F, Xiao S, Zhang Y, Liu Y, Yan Y, Xiang ZM*, Yu ZN*. ChAkt1 involvement in orchestrating the immune and heat shock responses in Crassostrea hongkongensis: Molecular cloning and functional characterization. Fish Shellfish Immunol. 2015 47:1015-23. 14. Qu F, XiangZM*, Zhang Y, Li J, Xiao S, Mao F, Yu ZN*. A novel p38 MAPK indentified from Crassostrea hongkongensis and its involvement in host response to immune challenges. Mol Immunol. 2016 79:113-24. 15. Fufa Qu, XiangZM*, Xiao S, Wang FF, Li J, Zhang Y, , Zhang YH, Qin YP, Ziniu Yu*. c-Jun N-terminal kinase (JNK) is involved in immune defense against bacterial infection in Crassostrea hongkongensis. Developmental and Comparative Immunology. 2016 32 1-9. 16. Fufa Qu, XiangZM*, Li J, Xiao S, Mao F, Qin YP, Zho u YL, Ma HT, Yu ZN*. A molluscan extracellular signal-regulated kinase is involved in host response to immune challenges in vivo and in vitro. Fish and Shellfish Immunology. 2017. 17. Fufa Qu, XiangZM*, Zhang Y, Li J, Xiao S, Zhang YH, Qin YP, Zhou YL, Yu ZN*. Molecular identification and functional characterization of a tumor necrosis factor (TNF) gene in Crassostrea hongkongensis. Immunobiology.2017. 18. Qu F, XiangZM#, Yu ZN*. The first molluscan acute phase serum amyloid A (A-SAA) identified from oyster Crassostrea hongkongensis: Molecular cloning and functional characterization. Fish Shellfish Immunol. 2014 39:145-51. 19. Qu F, XiangZM#, Zhang Y, Li J, Yu ZN*. The identification of the first molluscan Akirin2 with immune defense function in the Hong Kong oyster Crassostrea hongkongensis. Fish Shellfish Immunol. 2014, 41:455-465. 20. Fufa Qu,Xiang ZM#, Wang FF, Yu ZN*. A novel prostaglandin E receptor 4 (PTGER4) gene involved in host protection against immune challenges in Crassostrea hongkongensis. Fish Shellfish Immunol. 2014, 42: 316-324. 21. Qu F, XiangZM#, Wang F, Zhang Y, Li J, Xiao S, Yu ZN*. Identification and function of an evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) from Crassostrea hongkongensis. Dev Comp Immunol. 2015, 53(1):244-252. 22. Liu F, Zhu C, Xiao J, Wang Y, Tang W, Yuan W, Xiang ZM et al. A novel human KRAB-containing zinc-finger gene ZNF446 inhibits transcriptional activities of SRE and AP-1. Biochem Biophys Res Commun. 2005 333:5-13. 23. Zhang DF, Jiang B, Xiang ZM, Wang SY*. Functional characterisation of altered outer membrane proteins for tetracycline resistance in Escherichia coli. Int J Antimicrob Agents. 2008 32:315-9. 24. Li Z, Xu X, Huang L, Wu J, Lu Q, Xiang ZM, Weng SP, He JG*. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish Shellfish Immunol. 2010 29:399-406. 25. Chen WJ, Guo CJ, Zhou ZC, Yuan LQ, Xiang ZM, Weng SP, He JG*. Molecular cloning of IKKbeta from the mandarin fish Siniperca chuatsi and its up-regulation in cells by ISKNV infection. Vet Immunol Immunopathol. 2011 139:61-6. 26. Li J, ZY, XiangZM, Xiao S, Yu F, Yu ZN*. High mobility group box 1 can enhance NF-kappaB activation and act as a pro-inflammatory molecule in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2013 35:63-70. Fish Shellfish Immunol. 2008 35:63-70. 27. Li J, Zhang Y, Xiang ZM, Tong Y, Qu F, Yu Z*. Genomic characterization and expression analysis of five novel IL-17 genes in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2014,40 455-465. 28. Li J, Zhang Y, Liu Y, Xiang ZM, Qu F, Yu Z*. Cloning and characterization of three suppressors of cytokine signaling (SOCS) genes from the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2015, 44(2):525-32. 29. Li J, Zhang Y, Liu Y, Xiang ZM, Qu F, Yu ZN*. A thymosin beta-4 is involved in production of hemocytes and immune defense of Hong Kong oyster, Crassostrea hongkongensis. Dev Comp Immunol. 2016, 57, 1-9. 30. Zhang Y, Li J, Yu F, Tong Y, Xiang ZM, Yu ZN*. Identification and functional characterization of SIMPL in Crassostrea gigas reveals its ancient origin and involvement in the regulation of Rel/NF-kappaB transcription activity. Fish Shellfish Immunol. 2014 40(1):239-44.. 31. Zhang Y, He X, Yu F, Xiang ZM, Li J, Thorpe KL, Yu ZN*. Characteristic and functional analysis of toll-like receptors (TLRs) in the lophotrocozoan, Crassostrea gigas, reveals ancient origin of TLR-mediated innate immunity. PLoS One. 2013 8:e76464. 32. Zhang Y, Sun J, Mu H, Li J, Xu F, Xiang ZM, Yu ZN*. Proteomic basis of stress responses in the gills of the Pacific oyster Crassostrea gigas. J Proteome Res. 2015;14(1):304-17. 33. Qu F, XiangZM, Wang F, Zhang Y, Tong Y, Li J, Yu ZN*. A novel molluscan Fos gene with immune defense function identified in the Hong Kong oyster, Crassostrea hongkongensis. Dev Comp Immunol. 2015;51(1):194-201. 34. Xu F, Zhang Y, Li J, Xiang ZM, Yu ZN*. Expression and Function analysis of two Naturally Truncated MyD88 variants in the Pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 2015 45(2):510-6. 35. Xu F, Li J, Zhang Y, Li X, Xiang ZM, Yu ZN*. CgIkappaB3, the third novel inhibitor of NF-kappa B (IkappaB) protein, is involved in the immune defense of thePacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2015 46(2):648-55. 36. Zhang YH, Zhang Y, Li J, Xiao S, Xiang ZM, Wang ZP, Yan XW, Yu ZN*. Artificial interspecific backcrosses between the hybrid of female Crassostreahongkongensis× male C. gigas and the two parental species. Aquaculture. 2016:450: 95–101.