个人简介
招生专业
070703-海洋生物学
100701-药物化学
招生方向
海洋微生物天然产物
海洋微生物药物
教育背景
2009-09--2012-06 中国海洋大学 博士
2006-09--2009-06 青岛科技大学 硕士
2002-09--2006-06 青岛科技大学 学士
工作简历
2019-03~2020-03,美国加州大学洛杉矶分校, 访问学者
2016-12~现在, 中国科学院南海海洋研究所, 副研究员
2012-09~2016-12,中国科学院南海海洋研究所, 助理研究员
专利成果
（ 1 ） 一类新颖结构倍半萜化合物及其在制备抗炎药物中的应用, 发明, 2019, 第 1 作者, 专利号: ZL201610578329.5
（ 2 ） 海洋曲霉SCSIO 05879制备Versicoloids A 和B及在抗胶孢炭疽菌药物中的应用, 发明, 2018, 第 1 作者, 专利号: ZL201710505896.2
（ 3 ） 抗生素Versicoloids A 和B及其制备方法和在制备抗植物病原菌药物中的应用, 发明, 2017, 第 1 作者, 专利号: ZL201610046509.9
（ 4 ） 一种α-吡喃酮混源萜及其制备方法和应用, 发明, 2017, 第 1 作者, 专利号: ZL201510244085.2
（ 5 ） 吡啶酮生物碱类化合物及其制备方法和在制备抗肿瘤药物中的应用, 发明, 2016, 第 1 作者, 专利号: ZL201410021280.4
（ 6 ） 生物碱类化合物在制抗肠道病毒及乙酰胆碱酯酶抑制剂药物中的应用, 发明, 2015, 第 1 作者, 专利号: ZL201410021315.4
（ 7 ） 一种水杨醇类化合物及其在制备抗肠道病毒药物中的应用, 发明, 2019, 第 1 作者, 专利号: ZL201710052984.1
出版信息
已在Org. Lett., Org. Chem. Front., J. Nat. Prod., Org. Biomol. Chem., Bioorg. Med. Chem.等刊物上发表SCI论文90余篇，近五年第一/通讯作者
科研项目
（ 1 ） 影响PI3K/Akt通路的西南沙海绵真菌来源功能分子的发现及其机理研究, 主持, 国家级, 2018-01--2021-12
（ 2 ） 三株西沙海绵来源真菌中抗手足口病致病病毒EV71活性代谢产物的发现, 主持, 国家级, 2016-01--2018-12
（ 3 ） 西沙海绵真菌来源的靶向抗肿瘤活性次生代谢产物的研究, 主持, 省级, 2016-01--2018-12
（ 4 ） 南海微生物中靶向AKT/ERK/CASP信号通路的抗肿瘤活性代谢产物及其作用机制研究, 主持, 省级, 2017-05--2020-04
（ 5 ） 红树拟盘多毛孢菌中抗H1N1流感病毒活性代谢产物的发现, 主持, 市地级, 2015-05--2017-04
（ 6 ） 南极来源真菌中抗菌活性次生代谢产物的研究, 主持, 市地级, 2014-01--2015-12
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
35. Han W, Cai J, Zhong W, Xu G, Wang F, Tian X, Zhou X*, Liu Q*, Liu Y, Wang J*. Protein tyrosine phosphatase 1B (PTP1B) inhibitors from the deep-sea fungus Penicillium chrysogenum SCSIO 07007. Bioorg Chem, 2020, 96, 103646.
34. Chen W, Li K, Lin X, Liao S, Yang B, Zhou X, Wang J, Liu Y*, Wang J*. Antioxidant CPA-type indole alkaloids produced from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Nat Prod Res, 2020, doi: 10.1080/14786419.2020.1749614.
33. Chen W, Liu H, Long J, Tao H, Lin X, Liao S, Yang B, Zhou X, Liu Y*, Wang J*. Asperpentenone A, A novel polyketide isolated from the deep-sea derived fungus Aspergillus sp. SCSIO 41024. Phytochem Lett, 2020, 35: 99–102. (Highlighted by Natural Products Reports)
32. Pang X, Lin X, Zhou X, Yang B, Tian X, Wang J*, Xu S*, Liu Y*. New quinoline alkaloid and bisabolane-type sesquiterpenoid derivatives from the deep-sea-derived fungus Aspergillus sp. SCSIO06786. Fitoterapia, 2020, 140: 104406.
31. Guo C, Wang P, Lin X, Salendra L, Kong F, Liao S, Yang B, Zhou X, Wang J*, Liu Y*. Phloroglucinol heterodimers and bis-indolyl alkaloids from the Sponge-Derived Fungus Aspergillus sp. SCSIO 41018. Org Chem Front, 2019, 6: 3053–3059. (Front Cover Article, Best Cover Winner in 2019)
30. Liu N, Peng S, Yang J, Cong Z, Lin X, Liao S, Yang B, Zhou X, Zhou X, Liu Y*, Wang J*. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301. Fitoterapia, 2019, 135: 27-32.
29. Guo C, Lin X, Liao S, Yang B, Zhou X, Yang X, Tian X, Wang J*, Liu Y.* Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720. Nat Prod Res, 2019, doi: 10.1080/14786419.2018.1553880.
28. Cong Z, Huang X*, Liu Y, Liu Y, Wang P, Liao S, Yang B, Zhou X, Huang D, Wang J*. Cytotoxic anthracycline and antibacterial tirandamycin analoguesfrom a marine-derived Streptomyces sp. SCSIO 41399. J Antibiot, 2019, 72: 45–49.
27. Pang X, Cai G, Lin X, Salendra L, Zhou X, Yang B, Wang J, Wang J*, Xu S*, Liu Y*. New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015. Mar. Drugs, 2019, 17, 398.
26. Wang J, Qing L, Zhao B, Cai L, Zhong Z, Liu Y, Zhou X*. Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium. Org Biomol Chem, 2019, 17(1): 195–202.
25. Wang J, Cong Z, Huang X, Hou C, Chen W, Tu Z, Huang D, Liu Y*. Soliseptide A, acyclic hexapeptidepossessing piperazicacid groups from Streptomyces solisilvae HNM30702. Org Lett, 2018, 20(5): 1371–1374.
24. Pang X, Lin X, Yang J, Zhou X, Yang B, Wang J*, Liu Y*. Spiro-Phthalides and isocoumarinsisolated from the marine-sponge-derived fungus Setosphaeria sp. SCSIO41009. J Nat Prod, 2018, 81(8), 1860−1868. (Top 20 Most Read Articles in August, 2018)
23. Pang X, Lin X, Wang P, Zhou X, Yang B, Wang J*, Liu Y*. Perylenequione derivatives with anticancer activities isolated from the marine sponge-derived fungus, Alternaria sp. SCSIO41014. Mar. Drugs, 2018, 16(8), 280.
22. Wang J*, Zhou L, Chen S, Yang B, Liao S, Kong F, Lin X, Wang F, Zhou X, Liu Y*. New chlorinated diphenyl ethers and xanthones from a deep-sea-derivedfungus Penicillium chrysogenum SCSIO 41001. Fitoterapia, 2018, 125, 49–54.
21. Pang X, Lin X, Wang J*, Liang R, Tian Y, Salendra L, Luo X, Zhou X, Yang B, Tu Z, Liu Y*. Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp. SCSIO41007. Steroids, 2018, 129, 41–46.
20. Wang J, He W, Kong F, Tian T, Wang P, Zhou X*, Liu Y*. Ochracenes A−I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis. J Nat Prod, 2017, 80(6): 1725–1733. (Highlighted by Natural Products Reports)
19. Wang J, Liang R, Liao S, Yang B, Tu Z, Lin X, Wang B, Liu Y*. Vaccinols J–S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii. Fitoterapia, 2017, 120: 164–170.
18. He W, Zhou X, Qin X, Mai Y, Lin X, Liao S, Yang B, Zhang T, Tu Z, Wang J*, Liu Y*. Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derivedfungus Gliomastix sp. ZSDS1-F7. Nat Prod Res, 2017, 31(5): 604–609.
17. Wang J, Wei X, Qin X, Tian X, Liao L, Li K, Zhou X, Yang X, Wang F, Tu Z, Chen B, Liu Y*. Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702, J Nat Prod, 2016, 79(1): 59–65. (Highlighted by Natural Products Reports)
16. Wang J, He W, Huang X, Tian X, Liao S, Yang B, Wang F, Zhou X, Liu Y*. Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879, J Agric Food Chem, 2016, 64(16): 2910–2916.
15. Wang J, Qin X, Chen Z, Ju Z, He W, Tan Y, Zhou X, Tu Z, Lu F*, Liu Y*. Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni), Phytochem Lett, 2016, 15: 13–15.
14. Zhao B#, Peng S#, He W, Liu Y, Wang J*, Zhou X*. Antitubercular and cytotoxic tigliane-type diterpenoidsfrom Croton tiglium, Bioorg Med Chem Lett, 2016, 26(20): 4996–4999.
13. Xu G#, Wang Z#, Zhao B, Liu N, Yang S, Liu Y, Wang J*, Zhou X*. Saniculamins A and B, two new flavonoids from Sanicula lamelligera Hance inhibiting LPS-inducednitric oxide release, Phytochem Lett, 2016, 18: 35–38.
12. Wang J, Wei X, Qin X, Lin X, Zhou X, Liao S, Yang B, Liu J, Tu Z, Liu Y*. Arthpyrones A–C, pyridine alkaloids from a sponge-derivied fungus Arthrinium arundinis ZSDS1-F3. Org Lett, 2015, 17(3): 656–659. (ACS Editors' Choice, Highlighted by Natural Products Reports)
11. Wang J, He W, Qin X, Wei X, Tian X, Liao L, Liao S, Yang B, Tu Z, Chen B, Wang F, Zhou X*, Liu Y*. Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp. SCSIO 05705, RSC Adv, 2015, 5(84): 68736–68742.
10. Wang J, Wang Z, Ju Z, Wan J, Liao S, Lin X, Zhang T, Zhou X, Chen H, Tu Z*, Liu Y*. Cytotoxic cytochalasins from marine-derived fungus Arthrinium arundinis. Planta Med, 2015, 81(2): 160–166.
9. Wang J, He W, Zhang X, Zhao B, Liu Y, Zhou X*. Dicarabrol, a new dimer icsesquiterpene from Carpesium abrotaoides L. Bioorg Med Chem Lett, 2015, 25(19): 4082–4084.
8. Wang J#, Yang S#, Liu Y, Li D, He W, Zhang X, Liu Y*, Zhou X*. Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium. Bioorg Med Chem Lett, 2015, 25(9): 1986–1989.
7. Yang S#, Liu Y#, Wang J*, Wang Y, Pan W, Sheng W, Cai R, Zhou X*. Isoquinoline alkaloids from Zanthoxylum simulans and their biological evaluation, J Antibiot, 2015, 68(4): 289–292.
6. Wang J, Wei X, Qin X, Chen H, Lin X, Zhang T, Yang X, Liao S, Yang B, Liu J, Zhou X, Tu Z*, Liu Y*. Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce. Phytochem Lett, 2015, 12: 59–62.
5. Wang J#, Qin X#, Xu F, Zhang T, Liao S, Lin X, Yang B, Liu J, Wang L, Tu Z*, Liu Y*. Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation. Nat Prod Res, 2015, 29(18): 1761–1765.
4. Wang J, Wei X, Lu X, Xu F, Wan J, Lin X, Zhou X, Liao S, Yang B, Tu Z, Liu Y*. Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel(L.) Druce. Tetrahedron, 2014, 70(51): 9695–9701.
3. Wang J, Deng Y, Yang S, Liu Y, Wang Y, Pan W, Zhou X*. Characterization and biological evaluation of six new dimericlignans with an unusual α,β-unsaturated ketone motif from Zanthoxylum simulans, Bioorg Med Chem Lett, 2014, 24(19): 4667–4671.
2. Wang J, Xu F, Wang Z, Lu X, Wan J, Yang B, Zhou X, Zhang T, Tu Z, Liu Y*. A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. Nat Prod Res, 2014, 28(14): 1070–1074.
1. Wang J#, Lin X#, Qin C, Liao S, Wan J, Zhang T, Liu J, Fredimoses M, Chen H, Yang B, Zhou X, Yang X, Tu Z*, Liu Y*. Antimicrobial and antiviral sesquiterpenoids from sponge-associated fungus, Aspergillus sydowii ZSDS1-F6. J Antibiot, 2014, 67(8): 581–583.
京公网安备 11010802027423号