个人简介

1994-present Charles L. Huisking Professor of Chemistry, University of Notre Dame 1986-1994 Professor, University of Notre Dame 1980-1986 Associate Professor, University of Notre Dame 1974-1980 Assistant Professor, University of Notre Dame 1973-1974 Postdoctoral Research Associate, University of California, Santa Cruz 1973 Ph.D. in Chemistry, The Ohio State University 1968 B.S. in Chemistry, Seton Hall University Award: 2007 College of Science Shilts-Leonard Teaching Award 2006, 2002, 1999 Kaneb Teaching Award 1993 Thomas P. Madden Teaching Award 1977-1979 Alfred P. Sloan Fellowship

研究领域

Organic Chemistry

Professor Creary's research interests are a blend of synthetic and mechanistic organic chemistry. Studies in his laboratory are directed toward the study of novel reaction mechanisms and reactive intermediates. Reactions that proceed via carbocations, carbenes, free radicals, radical anions and radical cations are current areas of interest. In the carbocation area, studies are directed toward so-called "electron deficient cations", [R2CE]+. Studies have shown that a variety of such carbocations that are substituted with electron-withdrawing groups E (such as carbonyl, phosphoryl, and sulfonyl) can be generated and, in certain instances, are more stable than expected on the basis of the electron-withdrawing properties of the group E. Substitution mechanisms of halodiazirines are also of interest. It has been found via 15N labeling studies, that under appropriate conditions, either C-azidodiazirines, or N-azidodiazirines, can be formed as transient intermediates when halodiazirines react with azide ion. Substitution reactions can proceed via Sn2' or SRN1 mechanisms. The possible involvement of the isomeric and formally antiaromatic diazirinyl anions is under investigation. Carbene chemistry, and the effect of neighboring silicon on carbenic centers, is also an area of current interest. We have generated a number of silicon containing carbenes, and these carbenes rearrange to give products that are indicative of a special interaction between silicon and the carbenic center. Silicon-activated hydrogen migration to carbenic centers is one of the facile processes that silyl carbenes undergo. A novel β-thiolactam forming reaction has been discovered in our laboratory starting with readily available aryl esters. Subsequent ozonolysis allows preparation of a variety of b-lactam systems. The mechanism, scope, and obvious synthetic utility of this reaction are currently under investigation, as are carbocationic intermediates derived from such systems.

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Creary, X.; Heffron, A. "gamma-Silyl-Substituted Norbornyl Carbocations and Carbenes." J. Org. Chem. 2014, 79 (6), 2547-2555. Creary, X. "3-Trimethylsilylcyclobutylidene. The gamma-Effect of Silicon on Carbenes." J. Am. Chem. Soc. 2013, 135 (17), 6570-6578. Creary, X.; Anderson, A.; Brophy, C.; Crowell, F.; Funk, Z. "Method for Assigning Structure of 1,2,3-Triazoles." J. Org. Chem. 2012, 77 (19), 8756-8761. Creary, X.; Hinckley, J.; Kraft, C.; Genereux, M. "Photochemical Behavior of Cyclopropyl-Substituted Benzophenones and Valerophenones." J. Org. Chem. 2011, 76 (7), 2062-2071. Creary, X.; Kochly, E.D. "gamma-Silyl Cyclobutyl Carbocations." J. Org. Chem. 2009, 74 (23), 9044-9053. Creary, X.; Kochly, E.D. "Systematic Repression of beta-Silyl Carbocation Stabilization." J. Org. Chem. 2009, 74 (18), 7210.