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Medicinal Chemistry Structural Biology and Biochemistry

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Chen, Kuan I., Challinor, Victoria L., Kielmann, Linda, Sharpe, Philip C., De Voss, James J., Kappler, Ulrike, McEwan, Alastair G. and Bernhardt, Paul V. (2014) Electrochemically mediated enantioselective reduction of chiral sulfoxides. Journal of Biological Inorganic Chemistry, 20 2: 395-402. doi:10.1007/s00775-014-1215-5 Singh, Arti A., Rowley, Jessica A., Schwartz, Brett D., Kitching, William and De Voss, James J. (2014) Oxidative carbon-carbon bond cleavage is a key step in spiroacetal biosynthesis in the fruit fly Bactrocera cacuminata. Journal of Organic Chemistry, 79 17: 7799-7821. doi:10.1021/jo500791y Alonso, Hernan, Kleifeld, Oded, Yeheskel, Adva, Ong, Poh C., Liu, Yu C., Stok, Jeanette E., De Voss, James J. and Roujeinikova, Anna (2014) Structural and mechanistic insight into alkane hydroxylation by Pseudomonas putida AlkB. Biochemical Journal, 460 2: 283-293. doi:10.1042/BJ20131648 Cryle, Max J., Hayes, Patricia Y. and De Voss, James J. (2012) Enzyme-substrate complementarity governs access to a cationic reaction manifold in the P450(BM3) -catalysed oxidation of cyclopropyl fatty acids. Chemistry : A European Journal, 18 50: 15994-15999. doi:10.1002/chem.201203035 Challinor, Victoria L., Stuthe, Julia M. U., Parsons, Peter G., Lambert, Lynette K., Lehmann, Reginald P., Kitching, William and De Voss, James J. (2012) Structure and bioactivity of steroidal saponins isolated from the roots of Chamaelirium luteum (False Unicorn). Journal of Natural Products, 75 8: 1469-1479. doi:10.1021/np300393y Johnston, Jonathan B., Singh, Arti A., Clary, Anaelle A., Chen, Chiung-Kuan, Hayes, Patricia Y., Chow, Sharon, De Voss, James J. and de Montellano, Paul R. O. (2012) Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1. Bioorganic and Medicinal Chemistry, 20 13: 4064-4081. doi:10.1016/j.bmc.2012.05.003 Slessor, Kate E., Hawkes, David B., Farlow, Anthony, Pearson, Andrew G., Stok, Jeanette E. and De Voss, James J. (2012) An in vivo cytochrome P450(cin) (CYP176A1) catalytic system for metabolite production. Journal of Molecular Catalysis B: Enzymatic, 79 15-20. doi:10.1016/j.molcatb.2012.03.007 Challinor, Victoria L., Piacente, Sonia and De Voss, James J. (2012) NMR assignment of the absolute configuration of C-25 in furostanol steroidal saponins. Steroids, 77 6: 602-608. doi:10.1016/j.steroids.2012.02.002 Challinor, Victoria L., Parsons, Peter G., Chap, Sonet, White, Eve F., Blanchfield, Joanne T., Lehmann, Reginald P. and De Voss, James J. (2012) Steroidal saponins from the roots of Smilax sp.: Structure and bioactivity. Steroids, 77 5: 504-511. doi:10.1016/j.steroids.2012.01.009 Challinor, Victoria L. and De Voss, James J. (2012) Assignment of stereochemistry in open-chain steroidal saponins. Pure and Applied Chemistry, 84 6: 1469-1478. doi:10.1351/PAC-CON-11-09-12 Challinor, Victoria L., Hayes, Patricia Y., Bernhardt, Paul V., Kitching, William, Lehmann, Reginald P. and De Voss, James J. (2011) Revision of the absolute configurations of bethosides B and C and their aglycone. Journal of Organic Chemistry, 76 17: 7275-7280. doi:10.1021/jo2012797 Matovic, Nicholas J., Stuthe, Julia M. U., Challinor, Victoria L., Bernhardt, Paul V., Lehmann, Reginald P., Kitching, William and De Voss, James J. (2011) The truth about false unicorn (Chamaelirium luteum): Total synthesis of 23R,24S-Chiograsterol B defines the structure and stereochemistry of the major saponins from this medicinal herb. Chemistry-A European Journal, 17 27: 7578-7591. doi:10.1002/chem.201100503 Matovic, Nicholas J., Hayes, Patricia Y., Penman, Kerry, Lehmann, Reginald P. and De Voss, James J. (2011) Polyunsaturated alkyl amides from Echinacea: Synthesis of diynes, enynes, and dienes. Journal of Organic Chemistry, 76 11: 4467-4481. doi:10.1021/jo200289f Slessor, KE, Farlow, AJ, Cavaignac, SM, Stok, JE and De Voss, JJ (2011) Oxygen activation by P450(cin): Protein and substrate mutagenesis. Archives of Biochemistry And Biophysics, 507 1: 154-162. doi:10.1016/j.abb.2010.09.009 Booth, Yvonne K., Kitching, William and De Voss, James J. (2011) Biosynthesis of the spiroacetal suite in bactrocera tryoni. ChemBioChem, 12 1: 155-172. doi:10.1002/cbic.201000481 Hawkes, David B., Slessor, Kate E., Bernhardt, Paul V. and De Voss, James J. (2010) Cloning, expression and purification of cindoxin, an unusual FMN-containing cytochrome P450 redox partner. ChemBioChem, 11 8: 1107-1114. doi:10.1002/cbic.201000119

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