Gillam, Elizabeth - University of Queensland - School of Chemistry and Molecular Biosciences

研究领域

Biomolecular Chemistry Medicinal Chemistry Molecular Genetics and Genomics Science Education

近期论文

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Zaugg, Julian, Gumulya, Yosephine, Gillam, Elizabeth M. J. and Bodén, Mikael (2014). Computational tools for directed evolution: a comparison of prospective and retrospective strategies. In Elizabeth M. J. Gillam, Janine N. Copp and David F. Ackerley (Ed.), Directed evolution library creation: methods and protocols 2nd ed. (pp. 315-333) New York, NY, United States: Humana Press. doi:10.1007/978-1-4939-1053-3_21 Behrendorff, James B. Y. H, Johnston, Wayne A. and Gillam, Elizabeth M. J (2014) Restriction Enzyme-Mediated DNA Family Shuffling. Methods in Molecular Biology, 1179 175-187. doi:10.1007/978-1-4939-1053-3_12 Gillam, Elizabeth M. J. and Hayes, Martin A. (2013) The evolution of cytochrome P450 enzymes as biocatalysts in drug discovery and development. Current Topics in Medicinal Chemistry, 13 18: 2254-2280. doi:10.2174/15680266113136660158 Behrendorff, James B. Y. H., Moore, Chad D., Kim, Keon-Hee, Kim, Dae-Hwan, Smith, Christopher A., Johnston, Wayne A., Yun, Chui-Ho, Yost, Garold S. and Gillam, Elizabeth M. J. (2012) Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli. Chemical Research in Toxicology, 25 9: 1964-1974. doi:10.1021/tx300281g Johnston, Wayne A., Hunter, Dominic J. B., Noble, Christopher J., Hanson, Graeme R., Stok, Jeanette E., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2011) Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes. Journal of Biological Chemistry, 286 47: 40750-40759. doi:10.1074/jbc.M111.300871 Hunter, D.J.B., Behrendorff, J.B.Y.H., Johnston, W.A., Hayes, P.Y., Huang, W., Bonn, B., Hayes, M.A., De Voss, J.J. and Gillam, E.M.J (2011) Facile production of minor metabolites for drug development using a CYP3A shuffled library. Metabolic Engineering, 13 6: 682-693. doi:10.1016/j.ymben.2011.09.001 Johnston, Wayne A., Huang, Weiliang, De Voss, James J., Hayes, Martin A. and Gillam, Elizabeth M.J. (2008) Quantitative whole-cell cytochrome P450 measurement suitable for high-throughput application. Journal of Biomolecular Screening, 13 2: 135-141. doi:10.1177/1087057107312780 Gillam, E. M. J. (2008) Engineering cytochrome P450 enzymes. Chemical Research in Toxicology, 21 1: 220-231. doi:10.1021/tx7002849 Johnston, Wayne A., Huang, Weiliang, De Voss, James J., Hayes, Martin A. and Gillam, Elizabeth M.J. (2007) A shuffled CYP1A library shows both structural integrity and functional diversity. Drug Metabolism And Disposition, 35 12: 2177-2185. doi:10.1124/dmd.107.017939 Huang, Weiliang, Johnston, Wayne A., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2007) A shuffled CYP2C library with a high degree of structural integrity and functional versatility. Archives of Biochemistry And Biophysics, 467 2: 193-205. doi:10.1016/j.abb.2007.08.023 Gillam, E. M. J. and Hunter, D. J. B. (2007). Chemical Defence and Exploitation: Biotransformation of Xenobiotics by Cytochrome P450 Enzymes. In Astrid Sigel, Helmut Sigel and Roland K. O. Sigel (Ed.), Metal Ions in Life Sciences (pp. 477-560) West Sussex: John Wiley and sons. Avent, Kathryn M., DeVoss, J. J. and Gillam, Elizabeth M. J. (2006) Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites. Chemical Research In Toxicology, 19 7: 914-920. doi:10.1021/tx0600090 Shukla, Alka, Gillam, Elizabeth M., Mitchell, Deanne J. and Bernhardt, Paul V. (2005) Direct electrochemistry of enzymes from the cytochrome P4502C family. Electrochemistry Communications, 7 4: 437-442. doi:10.1016/j.elecom.2005.02.021 Notley, LM, Crewe, KH, Taylor, PJ, Lennard, MS and Gillam, EMJ (2005) Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives. Chemical Research In Toxicology, 18 10: 1611-1618. doi:10.1021/tx050140s