Degnan, Bernie - University of Queensland - School of Biological Sciences

研究领域

Genomes, Development & Evolution We are interested in the genomic, cellular and developmental mechanisms that underpin the formation and evolution of animals. Our lab studies a wide range of marine invertebrates, some that have traits of economic value and others that act as models to address fundamental questions in biology and biomedicine. 1. The origin of animal complexity The genome orchestrates the formation and maintenance of animal body plans. We seek to understand the nature and origin of the fundamental genomic rules governing animal multicellularity and complexity. Many of our studies focus on a simple marine sponge, and current research efforts include the analysis of development, stem cells and regeneration. 2. Functional genomics and evolution of biomineralization The instructions to fabricate shells and skeletons of phenomenal strength, purity and beauty are encoded in the genomes of a wide range of animals. We investigate how genes and their products come together to direct the formation and patterning of the biominerals that build these structures. Some of these projects are in collaboration with industry partners with interests in the fabrication of materials of commercial value. 3. Marine invertebrate biology We have a general interest in the life cycles of coral reef invertebrates, and currently study a range of organismal phenomena from molecular, cellular and developmental perspectives. Larval biology and metamorphosis are long-standing points of focus.

近期论文

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McDougall, Carmel, Woodcroft, Ben J. and Degnan, Bernard M. (2016) The widespread prevalence and functional significance of silk-like structural proteins in metazoan biological materials. PLoS ONE, 11 7: . doi:10.1371/journal.pone.0159128 Wang, Tianfang, Nuurai, Parinyaporn, McDougall, Carmel, York, Patrick S., Bose, Utpal, Degnan, Bernard M. and Cummins, Scott F. (2016) Identification of a female spawn-associated Kazal-type inhibitor from the tropical abalone Haliotis asinina. Journal of Peptide Science, 22 7: 461-470. doi:10.1002/psc.2887 Kocot, Kevin M., Aguilera, Felipe, McDougall, Carmel, Jackson, Daniel J. and Degnan, Bernard M. (2016) Sea shell diversity and rapidly evolving secretomes: insights into the evolution of biomineralization. Frontiers in Zoology, 13 23: . doi:10.1186/s12983-016-0155-z Levin, Michal, Anavy, Leon, Cole, Alison G., Winter, Eitan, Mostov, Natalia, Khair, Sally, Senderovich, Naftalie, Kovalev, Ekaterina, Silver, David H., Feder, Martin, Fernandez-Valverde, Selene L., Nakanishi, Nagayasu, Simmons, David, Simakov, Oleg, Larsson, Tomas, Liu, Shang-Yun, Jerafi-Vider, Ayelet, Yaniv, Karina, Ryan, Joseph F., Martindale, Mark Q., Rink, Jochen C., Arendt, Detlev, Degnan, Sandie M., Degnan, Bernard M., Hashimshony, Tamar and Yanai, Itai (2016) The mid-developmental transition and the evolution of animal body plans. Nature, 531 7596: 637-+. doi:10.1038/nature16994 Fernandez-Valverde, Selene L. and Degnan, Bernard M. (2016) Bilaterian-like promoters in the highly compact Amphimedon queenslandica genome. Scientific Reports, 6 Art No.: 22496: . doi:10.1038/srep22496 Sogabe, Shunsuke, Nakanishi, Nagayasu and Degnan, Bernard M. (2016) The ontogeny of choanocyte chambers during metamorphosis in the demosponge Amphimedon queenslandica. Evodevo, 7 6: 1-13. doi:10.1186/s13227-016-0042-x Jindrich, Katia and Degnan, Bernard M. (2016) The diversification of the basic leucine zipper family in eukaryotes correlates with the evolution of multicellularity. BMC Evolutionary Biology, 16 28: 1-12. doi:10.1186/s12862-016-0598-z McDougall, Carmel, Moase, Patrick and Degnan, Bernard M. (2016) Host and donor influence on pearls produced by the silver-lip pearl oyster, Pinctada maxima. Aquaculture, 450 313-320. doi:10.1016/j.aquaculture.2015.08.008 Wollesen, Tim, Rodriguez Monje, Sonia Victoria, McDougall, Carmel, Degnan, Bernard M. and Wanninger, Andreas (2015) The ParaHox gene Gsx patterns the apical organ and central nervous system but not the foregut in scaphopod and cephalopod mollusks. EvoDevo, 6 1: . doi:10.1186/s13227-015-0037-z Wollesen, Tim, Rodriguez Monje, Sonia Victoria, Todt, Christiane, Degnan, Bernard M. and Wanninger, Andreas (2015) Ancestral role of Pax2/5/8 in molluscan brain and multimodal sensory system development. BMC Evolutionary Biology, 15 10: 1-19. doi:10.1186/s12862-015-0505-z Gaiti, Federico, Fernandez-Valverde, Selene L., Nakanishi, Nagayasu, Calcino, Andrew D., Yanai, Itai, Tanurdzic, Milos and Degnan, Bernard M. (2015) Dynamic and Widespread lncRNA Expression in a Sponge and the Origin of Animal Complexity. Molecular Biology and Evolution, 32 9: 2367-2382. doi:10.1093/molbev/msv117 Fernandez-Valverde, Selene L., Calcino, Andrew D. and Degnan, Bernard M. (2015) Deep developmental transcriptome sequencing uncovers numerous new genes and enhances gene annotation in the sponge Amphimedon queenslandica. BMC Genomics, 16 1: 1-11. doi:10.1186/s12864-015-1588-z Grice, Laura F. and Degnan, Bernard M. (2015) The origin of the ADAR gene family and animal RNA editing. BMC Evolutionary Biology, 15 1: 1-7. doi:10.1186/s12862-015-0279-3 Baughman, Kenneth W., McDougall, Carmel, Cummins, Scott F., Hall, Mike, Degnan, Bernard M., Satoh, Nori and Shoguchi, Eiichi (2014) Genomic organization of Hox and ParaHox clusters in the echinoderm, Acanthaster planci. Genesis: The Journal of Genetics and Development, 53 12: 952-958. doi:10.1002/dvg.22840 Wollesen, Tim, McDougall, Carmel, Degnan, Bernard M. and Wanninger, Andreas (2014) POU genes are expressed during the formation of individual ganglia of the cephalopod central nervous system. EvoDevo, 5 41: . doi:10.1186/2041-9139-5-41 Sellars, Melony J., Rao, Min, O'Leary, Zach, Wood, Andrew, Degnan, Bernard M. and Cowley, Jeff A. (2014) Reduced loads of pre-existing Gill-associated virus (GAV) infection in juvenile Penaeus monodon injected with single or multiple GAV-specific dsRNAs. Aquaculture, 434 272-276. doi:10.1016/j.aquaculture.2014.08.017 Budd, Alyssa, McDougall, Carel, Green, Kathryn and Degnan, Bernard M. (2014) Control of shell pigmentation by secretory tubules in the abalone mantle. Frontiers in Zoology, 11 1: . doi:10.1186/s12983-014-0062-0 Nakanishi, Nagayasu, Sogabe, Shunsuke and Degnan, Bernard M. (2014) Evolutionary origin of gastrulation: Insights from sponge development. BMC Biology, 12 26: . doi:10.1186/1741-7007-12-26 Anavy, Leon, Levin, Michal, Khair, Sally, Nakanishi, Nagayasu, Fernandez-Valverde, Selene L., Degnan, Bernard M. and Yanai, Itai (2014) BLIND ordering of large-scale transcriptomic developmental timecourses. Development (Cambridge), 141 5: 1161-1166. doi:10.1242/dev.105288 Watson, Jabin R., Brennan, Timothy C. R., Degnan, Bernard M., Degnan, Sandie M. and Kromer, Jens O. (2014) Analysis of the biomass composition of the demosponge Amphimedon queenslandica on Heron Island Reef, Australia. Marine Drugs, 12 6: 3733-3753. doi:10.3390/md12063733