近期论文
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1. Wang S,Li J,Liu Y,Zhang J,ZhengX,Sun X,Lei S,Kang Z,Chen X,Lei M,Hu H, Zeng X, Hao L. Distinct roles of calmodulin and Ca2+/calmodulin-dependent protein kinase II in isopreterenol-induced cardiac hypertrophy. Biochem Biophys Res Commun. 2020 Jun 11;526(4):960-966.
2. Liu Y, Yan S, Chen S, Zhang J, Shen Y, Su J, He G, Feng R, Shao D,Hao L. Calmodulin mutant in central linker reduces the binding affinity with PreIQ and IQ while interacting with CaV1.2 channels. Biochem Biophys Res Commun. 2020 May 21;526(1):78-84.
3. Su J, Gao Q, Yu L, Sun X, Feng R, Shao D, Yuan Y, Zhu Z, Sun X, Kameyama M, Hao L. The LQT-associated calmodulin mutant E141G induces disturbed Ca2+-dependent binding and a vibration-like gating mode of the CaV1.2 channel. Am J Physiol Cell Physiol. 2020 May 1;318(5):C991-C1004.
4. Li J, Wang S, Zhang J, Liu Y, Zheng X, Ding F, Sun X, Zhao M,Hao L. The CaMKII phosphorylation site Thr1604 in the CaV1.2 channel is involved in pathological myocardial hypertrophy in rats. Channels. 2020 Apr;14(1):151-162.
5. Hu H, Zhou S, Sun X, Xue Y, Yan L, Sun X, Lei M, Li J, Zeng X, Hao L. A potent antiarrhythmic drug N-methyl berbamine extends the action potential through inhibiting both calcium and potassium currents. J Pharmacol Sci. 2020 Apr;142(4):131-139.
6. Mao N, Gao Q, Hu H, Zhu T, Hao L. BPA disrupts the cardioprotection by 17 beta-oestradiol against ischemia/reperfusion injury in isolated guinea pig hearts. Steroids. 2019 Jun;146:50-56.
7. Wang Y, Gu Z, Cao Z, Hao L. Nonylphenol can aggravate allergic rhinitis in a murine model by regulating important Th cell subtypes and their associated cytokines.Int Immunopharmacol. 2019 May;70:260-267.
8. Lei, M, Xu J, Gao Q, Minobe E, Kameyama M, Hao L. PKA phosphorylation of Cav1.2 channel modulates the interaction of calmodulin with the C terminal tail of the channel.J Pharmacol Sci.2018 Jun;137(2):187-194.
9. Zhao M, Lian W, Li Z, Shao D, Chen S, Sun X, Hu H, Feng R, Guo F, Hao L. Astragaloside IV Inhibits Membrane Ca2+ Current but Enhances Sarcoplasmic Reticulum Ca2+ Release. Am J Chin Med. 2017;45(4):863-877.
10. Yu L, Xu J, Minobe E, Kameyama A, Yang L, Feng R, Hao L, Kameyama M. Role of protein phosphatases in the run down of guinea pig cardiac Cav1.2 Ca2+ channels. Am J Physiol Cell Physiol. 2016 May 15;310(10):C773-9.
11. Zhao M, Feng R, Shao D, Liu S, Lei M, Wang H, Sun X, Guo F, Hu H, Kameyama M, Hao L. Mg(2+)-dependent facilitation and inactivation of L-type Ca(2+) channels in guinea pig ventricular myocytes. J Pharmacol Sci. 2015 Nov;129(3):143-9.
12. Sun X, MinD, WangY, Hao L.Potassium Aspartate Inhibits SH-SY5Y Cell Damage and Apoptosis Induced by Ouabain and H2O2. Mol Med Rep. 2015 Aug;12(2):2842-8.
13. Gao Q, Liu S, Guo F, Liu S, Yu X, Hu H, Sun X, Hao L, Zhu T. Nonylphenol affects myocardial contractility and L-type Ca(2+) channel currents in a non-monotonic manner via G protein-coupled receptor 30. Toxicology. 2015 Aug 6;334:122-9.
14. Zhao M, Shao D, Yu L, Sun X, Wang Y, Hu H, Feng R, Gao Q, Guo F, Hao L. Electrophysiological effect and the gating mechanism of astragaloside IV on L-type Ca(2+) channels of guinea-pig ventricular myocytes. Eur J Pharmacol. 2015 Aug 5;760:27-35.
15. Sun Y, XuJ, MinobeE, ShimoaraS, HaoL, Kameyama M. Regulation of the Cav1.2 Cardiac Channel by Redox via Modulation of CaM Interaction With the Channel. J Pharmacol Sci. 2015 Jul;128(3):137-43.
16. Feng R, Liu Y, Sun X, Wang Y, Hu H, Guo H, Zhao J, Hao L.Molecular Cloning and Expression of the Calmodulin Gene From Guinea Pig Hearts. Exp Ther Med. 2015 Jun;9(6):2311-2318.
17. LiuS, XuJ, MinobeE, GaoQ, FengR, ZhaoM, GuoF, YangL, HaoL, Kameyama M. Nucleotides Maintain the Activity of Cav1.2 Channels in Guinea-Pig Ventricular Myocytes. Biochem Biophys Res Commun. 2015 May 8;460(3):813-8.
18. Guo F, Zhou P, Gao Q, Gong J, Feng R, Xu X, Liu S, Hu H, Zhao M, Adam H, Cai J, Hao L. Low-Mg(2+) treatment increases sensitivity of voltage-gated Na(+) channels to Ca(2+)/calmodulin-mediated modulation in cultured hippocampal neurons. Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C594-605.
著作（近五年）
1.全国高等院校规划教材《药物毒理学实验指导和习题集》，清华大学出版社，2019，主编
2.成人教育规划教材《药物毒理学》，上海科学技术出版社，2016，主编
3.全国高等院校规划教材《药物毒理学》，清华大学出版社，2016，主编
4.全国高等院校规划教材《药物毒理学》，人民卫生出版社，2015，副主编
其他学术成果（近五年）
1. 郝丽英;新型多肽调控CaMKII与CaV1.2通道正反馈相互作用改善心肌肥厚的机制,第十二届海峡两岸心血管科学研讨会,南京, 2019-9-19至2019-9-22.会议报告
2. 郝丽英;新型多肽调控细胞内钙稳态改善心肌肥厚的作用机制, 2019中国生理学会心血管生理学术研讨会,太原, 2019-8-19至2019-8-22.会议报告
3. Hao, Liying; The role of persistent activation of calmodulin-dependent protein kinase II in cardiac hypertrophy and the recovering effects induced by new-tpye peptide,第12届国际钙信号和细胞功能研讨会,辽宁，沈阳, 2018-7-18至2018-7-22.会议报告
4. Chen, Sichong; Liu, Yan; Li, Songlin; Lei, Ming; Wang, Xiaoning; Zhu, Zhengnan; Hao, Liying; The Influences of CaMKII phosphorylation on the combination of calmodulin with Cav1.2 channel and molecular docking analysis on the key binding amino acids, American Heart Association's Scientific Sessions, Chicago, 2018-11-10至2018-11-12.
5. Li, Jingyuan; Li, Songlin; Li, Zhuo; Kang, Ze; Wang, Siqi; Zhu, Xudong; Zhu, Zhengnan; Zhao, Meimi; Hu, Huiyuan; Hao, Liying; The mechanism underlying the role of CaMKII-mediated phosphorylation of Cav1.2 channel in cardiac hypertrophy and the effects of new-type peptide, 18th world congress of basic and clinical pharmacology, Kyoto, 2018-7-1至2018-7-6.
6. 举办第12届国际钙信号和细胞功能研讨会, 2018-7-18至2018-7-22,沈阳,中国生物物理学会,郝丽英，王路阳
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