个人简介

2012 American Chemical Society Macro 2012 Lecture Award (PMSE Division of ACS) 2012 Outstanding New Investigator Award (American Society of Gene and Cell Therapy) 2011 Lloyd H. Reyerson Chaired Professorship (U of MN) 2009 NIH Director’s New Innovator Award 2008 Camille Dreyfus Teacher-Scholar Award (Camille and Henry Dreyfus Foundation) 2007 Alfred P. Sloan Research Fellowship (Alfred P. Sloan Foundation) 2007 YWCA Rising Star (YWCA Academy of Career Women of Achievement) 2007-2009 Kavli Foundation Fellow (National Academy Frontiers of Science Program) 2007 OH Bioscience Thirty in Their 30s Award (BioOhio) 2006-2008 Lowenstein Scholar (Diana Lowenstein Endowment, UC) 2005 Beckman Young Investigator Award (Arnold and Mabel Beckman Foundation) 2005 Sigma Xi Outstanding Young Investigator Award (Sigma Xi Cincinnati Chapter) 2005 National Science Foundation CAREER Award 2003 American Chemical Society, Arthur K. Doolittle Award (Polymeric Materials Science and Engineering Division) 2002 National Institutes of Health, Individual National Research Service Award

研究领域

Nanoscience & Materials Chemistry/Chemical Biology/Polymer Chemistry

Materials chemistry is making a tremendous impact on modern medicine and biological research. We are interested in: 1) the development of novel carbohydrate-based polymers and dendrimers for the cellular delivery of RNA and DNA for research and therapeutic applications, 2) the design of glycopolymer and targeted contrast agents for magnetic resonance imaging and disease diagnosis, and 3) “theranostic” agents that combine the ability to perform therapeutic delivery and diagnostic imaging. Studies in these areas are centered both on understanding the fundamental mechanisms involved in biomaterial function and applied clinical use of our compounds for advanced diagnostic and treatment strategies. Our research is highly interdisciplinary and students in the Reineke lab routinely receive training in several areas of chemistry, biology, and medicine.

近期论文

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J. J. Gallagher, M. A. Hillmyer, T. M. Reineke “Isosorbide-based Polymethacrylates” ACS Sustainable Chemistry & Engineering, 2015, Just Accepted. ACS Editors’ Choice [link] W. Shearouse, L. Lillie, T. M. Reineke, W. Tolman “Sustainable Polyesters Derived from Glucose and Castor Oil: Building Block Structure Impacts Properties” ACS Macro Lett., 2015, 4, 284–288. [link] X. Wang, Y. Chen, L. Xue, N. Pothyaee, R. Zhang, J. Riffle, T. M. Reineke, L. A. Madsen “Diffusion of Drug Delivery Nanoparticles into Biogels using Time-Resolved MicroMRI” J. Phys. Chem. Lett., 2014, 5, 3825–3830. [link] J. M. Ting, T. S. Navale, F. S. Bates, T. M. Reineke “Design of Tunable Multicomponent Polymers as Modular Vehicles to Solubilize Highly Lipophilic Drugs” Macromolecules, 2014, 47, 6554–6565. [link] M. Nasiri, A. Bertrand, T. M. Reineke, M. A. Hillmyer “Polymeric nanocylinders by combining block copolymer self-assembly and nanoskiving” ACS Appl. Mater. Interfaces, 2014, 6, 16283–16288. [link] D. Sprouse, T. M. Reineke “Investigating the Effects of Block versus Statistical Glycopolycations Containing Primary and Tertiary Amines for Plasmid DNA Delivery” Biomacromolecules, 2014, 15, 2616–2628. [link] S. Tale, L. Yin, T. M. Reineke “Trehalose-functionalized block copolymers form serum-stable micelles” Polymer Chemistry, 2014, 5, 5160-5167. [link] Y. Wu, M. Wang, D. Sprouse, A. E. Smith, T. M. Reineke “Glucose-Containing Diblock Polycations Exhibit Molecular Weight, Charge, and Cell-Type Dependence for pDNA Delivery” Biomacromolecules, 2014, 15, 1716–1726. [link] S. S. Kelkar, L. Xue, T. S. Richard, T. M. Reineke “Lanthanide-Containing Polycations for Monitoring Polyplex Dynamics via Lanthanide Resonance Energy Transfer” Biomacromolecules, 2014, 15, 1612–1624. [link] J. J. Gallagher, M. A. Hillmyer, T. M. Reineke “Degradable Thermosets from Sugar-Derived Dilactones” Macromolecules, 2014, 47, 498–505. [link] M. C. Dalsin , S. Tale , and T. M. Reineke “Solution-State Polymer Assemblies Influence BCS Class II Drug Dissolution and Supersaturation Maintenance” Biomacromolecules, 2014, 15, 500–511. [link] X. Wang, S. S. Kelkar, A. G. Hudson, R. B. Moore, T. M. Reineke, L. A. Madsen “Quantitation of Complexed versus Free Polymers in Interpolyelectrolyte Polyplex Formulations” ACS Macro Lett., 2013, 2, 1038–1041. [link] P. A. Burke, S. H. Pun, T. M. Reineke “Advancing Polymeric Delivery Systems Amidst a Nucleic Acid Therapy Renaissance” ACS Macro Lett., 2013, 2, 928–934. [link] A. Sizovs, L. Xue, Z. Tolstyka, N. P. Ingle, Y. Wu, M. Cortez, T. M. Reineke “Poly(trehalose): Sugar-Coated Nanocomplexes Promote Stabilization and Effective Polyplex-Mediated siRNA Delivery” J. Am. Chem. Soc., 2013, 135, 15417–15424. [link]. L. Xue, N. P. Ingle, T. M. Reineke “Highlighting the Role of Polymer Length, Carbohydrate Size, and Nucleic Acid Type in Potency of Glycopolycation Agents for pDNA and siRNA Delivery” Biomacromolecules, 2013, 14, 3903–3915. [link] N. P. Ingle, L. Xue, T. M. Reineke “Spatio-Temporal Cellular Imaging of Polymer-pDNA Nanocomplexes Affords In Situ Morphology and Trafficking Trends” Mol. Pharm., 2013, 10, 4120–4135. [link] J. M. Ting, T. S. Navale, F. S. Bates, T. M. Reineke “Precise Compositional Control and Systematic Preparation of Multimonomeric Statistical Copolymers” ACS Macro Lett., 2013, 2, 770-774. [link] H. Li, M. A. Cortez, H. R. Phillips, Y. Wu, T. M. Reineke “Poly(2-deoxy-2-methacrylamidoglycopyranose)-b-Poly(methacrylate amine)s: Optimization of Diblock Glycopolycations for Nucleic Acid Delivery” ACS Macro Lett., 2013, 2, 230–235. [link] K. M. Fichter, N. P. Ingle, P. M. McLendon, T. M. Reineke “Polymeric Nucleic Acid Vehicles Exploit Active Interorganelle Trafficking Mechanisms” ACS Nano, 2013, 7, 347–364. [link] J. M. Bryson, J. W. Reineke, T. M. Reineke “Macromolecular Imaging Agents Containing Lanthanides: Can Conceptual Promise Lead to Clinical Potential?” Macromolecules, 2012, 45, 8939–8952. [link]