个人简介

B.S., 1993, Texas Tech Univ. Ph.D., 1997, Massachusetts Institute of Technology Postdoctoral Research Fellow, 1998-1999, Massachusetts Institute of Technology AwardOrganizationDivisionLevel CodeType CodeStart DateEnd Date Alfred P. Sloan FellowshipAlfred P. Sloan FoundationProfessionalFellowship20042006 MemberAmerican Chemical SocietyMichigan State University Local SectionProfessionalAdministration20012002 Young Investigator AwardOffice of Naval ResearchProfessionalHonors20012004 Presidential Early Career Award for Scientists and Engineers (PECASE)ProfessionalHonors2000 Early Career Scientist and Engineer AwardDepartment of EnergyDefense ProgramsProfessionalHonors1999 Ph.D.Massachusetts Institute of TechnologyGraduateDegree1997 Texaco FellowMassachusetts Institute of TechnologyGraduateFellowship19951996 Bachelor of ScienceTexas Tech UniversityUndergraduateDegree1993 Hoercht-Celanese Academic ScholarshipUndergraduateScholarship19911993

研究领域

Inorganic Organic Organometallic

(Research Description PDF - 977 kb) Developing sustainable and environmentally friendly approaches to products is one of the major challenges facing chemists. Some important developing methodologies for producing target compounds in fewer steps with less waste are catalyzed multicomponent coupling reactions, which allow access to structurally complex compounds in a single step. In one project, our group is developing titanium-catalyzed multicomponent coupling procedures to make nitrogen-based heterocycles either in a single pot or in a single step. Titanium catalysis is advantageous in that the metal is both abundant and nontoxic. In the exploding diagram at right are some of the procedures developed for heterocyclic synthesis. These new protocols are applied to natural product synthesis and investigated for their biological activity. For example, with the Tepe group, we have discovered a new class proteasome inhibitors based on the quinoline core structure with potential applications in inflammatory disease and cancers like multiple myeloma. To evaluate ligands for early transition metal catalysis, like in the project above, we have developed a chromium(VI), d0-system that is very synthetically versatile, NCr(NPri2)2X, where X is the ligand under scrutiny. Using this system, we parameterize ligands based on their sterics and electronics. The experimental results for a large selection of anionic ligands have been published and are shown below. Ligands are evaluated sterically using either %Vbur or Solid G. An illustration from the %Vbur analysis for the X = Cl compound is shown below, where the ligand’s effect on the primary coordination sphere is estimated. These new parameters, dubbed Ligand Donor Parameters (LDP), have been correlated with spectroscopic and reactivity data from a variety of systems and will hopefully be a useful tool for chemists when optimizing and designing high valent catalysts. In these projects, and others, we are attempting to widen and optimize the applications of transition metals, and we are investigating new possibilities for applications in human health and other areas.

近期论文

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"Effective donor abilities of E-t-Bu and EPh (E = O, S, Se, Te) to a high valent transition metal", Bemowski, R. D.; Singh, A. K.; Bajorek, B. J.; DePorre, Y.; Odom, A. L. Dalton Trans. 2014, 43, 12299. Link "Titanium-catalyzed, One Pot Syntheseis of 2-Amino-3-cyano-pyridines", Dissanayake, A. A.: Staples, R. J.; Odom, A. L. .Adv. Synth. Catal., 2014, 356, 1811-1822. Link "A 4-coordinate Ru(II) Imido: Unusual Geometry, Synthesis, and Reactivity", Singh, A. K.; Levine, B. G.; Staples, R. J.; Odom, A. L. Chem. Commun., 2013, 49, 10799-10801. Link "Single-site N-N Bond Cleavage by Mo(IV): Possible Mechanisms of Hydrazido(1-) to Nitrido Conversion", DiFranco, S. A.; Staples, R. J.; Odom, A. L. Dalton Trans. 2013, 42, 2530-2539. Link "Regioselective Conversion of Alkynes to 4-substituted and 3,4-disubstituted Isoxazoles Using Titanium-Catalyzed Multicomponent Coupling Reactions", Dissanayake, A. A.; Odom, A. L. Tetrahedron 2012, 68, 807-812. Link "Evaluation of Donor and Steric Properties of Anionic Ligands on High Valent Transition Metals", DiFranco, S. A.; Maciulis, N. A.; Staples, R. J.; Batrice, R. J.; Odom, A. L. Inorg. Chem. 2012, 51, 1187-1200. Link "Single-Step Synthesis of Pyrazoles Using Titanium Catalysis", Dissanayake, A. A.; Odom, A. L. Chem. Commun., 2012, 48, 440-442. Link "Synthesis and Hydroamination Catalysis with 3-Aryl Substituted Pyrrolyl and Dipyrrolylmethane Titanium(IV) Complexes", Swartz, D. L. II, Staples, R. J.; Odom, A. L. Dalton Trans. 2011, 7762. Link "Conversions Between Metal-Ligand Multiple Bond Types and Their Applications", Odom, A. L. Dalton Trans. 2011, 40, 2689. Link "Exploring the Coordination Modes of Pyrrolyl Ligands in Bis(imido) Uranium(VI) Complexes", Swartz, D. L., II; Spencer, L. P.; Scott, B. L.; Odom, A. L.; Boncella, J. M. Dalton Trans. 2010, 39, 6841. Link "Titanium-catalyzed one-pot multicomponent coupling reactions for direct access to substituted pyrimidines", Majumder, S.; Odom, A. L. Tetrahedron 2010, 66, 3152. This paper was also selected by editors of Victor Snieckus and Toni Rantanen for republication in Synfacts 2010, 6, 0642. Link "A Multicomponent Coupling Sequence for Direct Access to Substituted Quinolines", Majumder, S.; Gipson, K. R.; Odom, A. L. Organic Letters 2009, 11, 4720. Link "A One-Step Route to 2,3-Diaminopyrroles using a Titanium-Catalyzed Four-component Coupling", Barnea, E.; Majumder, S.; Staples, R. J.; Odom, A. L. Organometallics, 2009, 28, 3876. Link "Pyrazole Synthesis Using a Titanium-Catalyzed Multicomponent Coupling Reaction and Synthesis of Withasomnine", Majumder S.; Gipson, K. R.; Staples, R. J.; Odom, A. L. Advanced Synthesis and Catalysis 2009, 351, 2013. Link "A Readily-Prepared and Efficient Solid-Supported Scavenger for Molybdenum Alkoxides and a Structurally Characterized Model Complex", Lokare, K. S.; Odom, A. L. J. Organometallic Chem., 2009, 694, 223. Link "Carbonyl Olefination Using Readily Prepared Tungsten Metallacycles", Lokare, K. S.; Odom, A. L., Inorg. Chem. 2008, 47, 11191. Link "Synthesis, Properties, and Structure of Tethered Molybdenum Alkylidenes", Lokare, K. S.; Staples, R. J.; Odom, A. L. Organometallics 2008, 27, 5130-5138. Link "Effects of 5,5-Substitution on Dipyrrolylmethane Ligand Isomerization", Swartz, D. L.; Odom, A. L. Dalton Trans., 2008, 4254-8. Link "Zirconium Complexes Bearing a Tetradentate Dipyrrolyl Ligand", Barnea, E.; Odom, A. L. Dalton Trans., 2008, 4050-4. Link "Group-4 Dipyrrolylmethane Complexes in Intramolecular Olefin Hydroamination", Majumder, S.; Odom, A. L. Organometallics 2008, 27, 1174-1177. Link