个人简介

B.S., 1984, Univ. of Illinois at Urbana-Champaign Abbott Labs, 1984-1987 Ph.D., 1992, The Ohio State Univ. Postdoctoral Fellow, 1992-1995, American Cancer Society Univ. of Pennsylvania AwardOrganizationDivisionLevel CodeType CodeStart DateEnd Date Meritorious Faculty Award by the College of Natural Science Alumni AssociationProfessionalHonors2013 Merck Technology Symposium's Technology Collaboration AwardProfessionalHonors2013 Presidential Green Chemistry Challenge AwardProfessionalHonors2008 Smith First Edition Board of AdvisorsMcGraw HillProfessionalEditorial20032004 Yamanouchi USA Foundation Faculty AwardYamanouchi USA FoundationProfessionalHonors20012004 Teacher-Scholar AwardMichigan State UniversityCollege of Natural ScienceProfessionalHonors2001 Junior Faculty AwardSigma Xi Honor SocietyMichigan State UniversityProfessionalHonors2000 NSF Career AwardNational Science FoundationProfessionalHonors20002003 Novartis LecturerYale UniversityProfessionalProfessional Activities2000 MSU Senior Class Council Outstanding Faculty Award NomineeMichigan State UniversitySenior Class CouncilProfessionalHonors1998 MSU Chapter Mentor of the YearNational Organization for the Professional Advancement of Black Chemists and Chemical EngineersProfessionalHonors1998 NIH First AwardNational Institutes of HealthProfessionalHonors19982001 Advisory Board MemberNational Organization for the Professional Advancement of Black Chemists and Chemical EngineersProfessionalProfessional Activities1998 Postdoctoral FellowAmerican Cancer SocietyPostdoctoralFellowship19931995 Ph.D.The Ohio State UniversityGraduateDegree1992 Graduate Research AssociateThe Ohio State UniversityGraduateEducation19871992 Bachelor of ScienceUniversity of Illinois, Urbana-ChampaignUndergraduateDegree1984 Research AssistantshipAbbott LaboratoriesUndergraduateEducation19841987 Undergraduate ResearchUniversity of Illinois, Urbana-ChampaignUndergraduateEducation19831984 Air Force ROTC ScholarshipAir Force ROTCUndergraduateScholarship19801982 Dean's ListUniversity of Illinois, Urbana-ChampaignUndergraduateEducation

研究领域

Organic Organometallic

(Research Description PDF - 830 kb) Our group is interested in a) the total synthesis of biologically important natural products, b) the invention of new reactions and strategies in organic synthesis, and c) green chemistry. Green Chemistry: Central to our research is the development of efficient and environmentally benign reactions and strategies. The Pharmaceutical Roundtable of the American Chemical Society’s Green Chemistry Institute deemed cross-couplings that avoid haloaromatics as their top aspirational reaction. In collaboration with Professor Mitch Smith, we are inventing such reactions. Specifically, we are using catalytic C–H activation/borylation, often combined with subsequent chemical events, to generate pharmaceutically relevant building blocks for organic synthesis (Fig. 1). Another of our green chemistry ventures aims to minimizing the need for tin in various processes. For example, we were first to develop a Stille reaction that is catalytic in tin (Fig. 2). This chemistry employs polymethylhydrosiloxane (PMHS), which is an oligomeric non-toxic waste product of the silicon industry, as the stoichiometric reductant. We are now studying the kinetics and mechanism of this process so as to develop the next generation of this sequence. Invention of New Reactions: The principles of green chemistry also motivate us to create new synthetic methods. Here we have been focusing on the employment of organosilanes as both reagents and substrates in chemical transformations ranging from reductions using siloxane encapsulated Pd(0) nanoclusters, to enzymatic kinetic resolutions, to Wittig rearrangements (Fig. 3). Total Synthesis: The unifying thesis behind all of our methodological and mechanistic studies is that the chemistry to emerge from such studies should be applicable to real synthetic problems. We view target synthesis as the best proof of this concept. For example, as part of our green chemistry program, we look to make TMC-95A and autolytimycin by the strategic application of catalytic C–H borylations (Fig. 4).

近期论文

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"Synthesis and Structure-Activity Relationships of Novel Arylfluoroquinolone Antibacterial Agents" Chu, D. T. W.; Fernandes, P. B.; Claiborne, A. K.; Pihuleac, E.; Nordeen, C. W.; Maleczka, R. E., Jr.; Pernet, A. G. J. Med. Chem. 1985, 28, 1558–1564. "Synthesis and Structure-Activity Relationship of 1-Aryl-6,8-difluoroquinolone Antibacterial Agents" Chu, D. T. W.; Fernandes, P. B.; Maleczka, R. E., Jr.; Nordeen, C. W.; Pernet, A. G. J. Med. Chem. 1987, 30, 504–509. "Synthesis of 4-Oxo-4H-quino[2,3,4-i,j][1,4]-benoxazine-5-carboxylic Acid Derivatives" Chu, D. T. W.; Maleczka, R. E., Jr. J. Heterocyclic Chem. 1987, 24, 453–456. "Total Synthesis of Didemnins A, B, and C" Rinehart, K. L.; Kishore, V.; Nagarajan, S.; Lake, R. J.; Gloer, J. B.; Bozich, F. A.; Li, K.-M.; Maleczka, R. E., Jr.; Todsen, T. L.; Munro, M. H. G.; Sullins, D. W.; Sakai, R. J. Am. Chem. Soc. 1987, 109, 6846–6848. "Synthesis of 4,12-Dihydro-4-oxoquino-[1,8a,8-a,b]quinoxaline-5-carboxylic Acid Derivatives" Chu, D. T. W.; Maleczka, R. E., Jr.; Nordeen, C. W. J. Heterocyclic Chem. 1988, 25, 927–930. "Enantioselective Total Synthesis of (–)-9-Epiambrox, a Potent Ambergris-Type Olfactory Agent" Paquette, L. A.; Maleczka, R. E., Jr. J. Org. Chem. 1991, 56, 912–913. "Regio- and Stereoselective Oxidation of Unsaturated Bicyclo[2.2.2]octanones with Selenium Dioxide" Paquette, L. A.; Maleczka, R. E., Jr.; Qiu, F.-y. J. Org. Chem. 1991, 56, 2455–2461. "Adaptation of Oxyanionic Sigmatropy to the Convergent Enantioselective Synthesis of Ambergris-Type Odorants" Maleczka, R. E., Jr.; Paquette, L. A. J. Org. Chem. 1991, 56, 6538–6546. "Enantioselective Construction of Natural (+)-Pallescensin A. A Sigmatropic Pathway to Furanosequeterpines" Paquette, L. A.; Maleczka, R. E., Jr. J. Org. Chem. 1992, 57, 7118–7122. "Rapamycin Synthetic Studies. 1. Construction of the C(27) to C(42) Subunit" Smith, A. B., III; Condon, S. M.; McCauley, J. A.; Leahy, J. W.; Leazer, J. L., Jr.; Maleczka, R. E., Jr. Tetrahedron Lett. 1994, 35, 4907–4910. "Rapamycin Synthetic Studies. 2. Construction of the C(10) to C(26) Perimeter" Smith, A. B., III; Maleczka, R. E., Jr.; Leazer, J. L., Jr.; Leahy, J. W.; McCauley, J. A.; Condon, S. M. Tetrahedron Lett. 1994, 35, 4911–4914. "Total Synthesis of Rapamycin and Demethoxyrapamycin" Smith, A. B., III; Condon, S. M.; McCauley, J. A.; Leazer, J. L., Jr.; Leahy, J. W.; Maleczka, R. E., Jr. J. Am. Chem. Soc. 1995, 117, 5407–5408. "A Unified Total Synthesis of the Immunomodulators (–)-Rapamycin and (–)-27-Demethoxyrapamycin: Construction of the C(21–42) Perimeters" Smith, A. B., III; Condon, S. M.; McCauley, J. A.; Leazer, J. L., Jr.; Leahy, J. W.; Maleczka, R. E., Jr. J. Am. Chem. Soc. 1997, 119, 947–961. "A Unified Total Synthesis of the Immunomodulators (–)-Rapamycin and (–)-27-Demethoxyrapamycin: Assembly of the Common C(1–20) Perimeter and Final Elaboration" Smith, A. B., III; Condon, S. M.; McCauley, J. A.; Leazer, J. L., Jr.; Leahy, J. W.; Maleczka, R. E., Jr. J. Am. Chem. Soc. 1997, 119, 962–973. "Stereospecificity of the 1,2-Wittig Rearrangement: How Chelation Effects Influence Stereochemical Outcome" Maleczka, R. E., Jr.; Geng, F. J. Am. Chem. Soc. 1998, 120, 8551–8552. "Development of a One Pot Palladium Catalyzed Hydrostannylation/Stille Coupling Protocol with Catalytic Amounts of Tin" Maleczka, R. E., Jr.; Terstiege, I. J. Org. Chem. 1998, 63, 9622–9623. "A New Approach for the Generation and Reaction of Organotin Hydrides: The Development of Reactions Catalytic in Tin" Terstiege, I.; Maleczka, R. E., Jr. J. Org. Chem. 1999, 64, 342–343. "Application of a Three-Carbon Ring Expansion Process to Bridged Bicyclic Systems" Mi, B.; Maleczka, R. E., Jr. Tetrahedron Lett. 1999, 40, 2053–2056. "Synthetic Studies Toward Amphidinolide A: Synthesis of Fully Functionalized Subunits" Terrell, L. R.; Ward, J. S., III; Maleczka, R. E., Jr. Tetrahedron Lett. 1999, 40, 3097–3100. "Synthesis of Aryl and Alkyl Acylsilanes Using Trimethyl(tributylstannyl)silane" Geng, F.; Maleczka, R. E., Jr. Tetrahedron Lett. 1999, 40, 3113–3114.