Rendina, Louis - University of Sydney

研究领域

My research group is primarily interested in the medicinal chemistry of boron and the lanthanides, in particular gadolinium. We place a strong emphasis on the design and development of new drug classes and also medicinal agents with neutron and X-ray photon applications, particularly those involving the treatment of intractable and aggressive cancers such as those of the brain. We are heavily involved in the development of new boron and gadolinium agents for an exciting cancer treatment known as neutron capture therapy (NCT), one of the few groups in the world to be involved in this area of research. To date, we have discovered several new classes of DNA-, mitochondrial- and tumour-targeted compounds and we are currently exploring their use as potential BNCT and GdNCT agents. We are also interested in the use of boron clusters, in particular the carboranes, as unique classes of pharmacophore in drug design. Our research is funded by organizations including the Australian Research Council, The Prostate Cancer Foundation of Australia, Cure Cancer Australia Foundation and The National Breast Cancer Foundation.

近期论文

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Kahlert, J., Austin, C., Hall, A., Rawal, A., Hook, J., Rendina, L., Choucair, M. (2016). Site-specific synthesis of a hybrid boron-graphene salt. Chemical Communications, 52(6), 1290-1292. [More Information] Austin, C., Moir, M., Kahlert, J., Smith, J., Jamie, J., Kassiou, M., Rendina, L. (2015). Carborane-containing hydroxyamidine scaffolds as novel inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1). Australian Journal of Chemistry, 68(12), 1866-1870. [More Information] Narlawar, R., Werry, E., Scarf, A., Hanani, R., Chua, S., King, V., Barron, M., Martins, R., Ittner, L., Rendina, L., Kassiou, M. (2015). First demonstration of positive allosteric-like modulation at the human wild type translocator protein (TSPO). Journal of Medicinal Chemistry, 58(21), 8743-8749. [More Information] Kahlert, J., Bohling, L., Brockhinke, A., Stammler, H., Neumann, B., Rendina, L., Low, P., Weber, L., Fox, M. (2015). Syntheses and reductions of C-dimesitylboryl-1,2-dicarba-closo-dodecaboranes. Dalton Transactions, 44(21), 9766-9781. [More Information] Fenton, J., Busse, M., Rendina, L. (2015). Synthesis and DNA-binding studies of a dinuclear gadolinium(III)-platinum(II) complex. Australian Journal of Chemistry, 68(4), 576-580. [More Information] Austin, C., Rendina, L. (2015). Targeting key dioxygenases in tryptophan-kynurenine metabolism for immunomodulation and cancer chemotherapy. Drug Discovery Today, 20(5), 609-617. [More Information] Kahlert, J., Rawal, A., Hook, J., Rendina, L., Choucair, M. (2014). Carborane functionalization of the aromatic network in chemically-synthesized graphene. Chemical Communications, 50(77), 11332-11334. [More Information] Morrison, D., Aitken, J., De Jonge, M., Ioppolo, J., Harris, H., Rendina, L. (2014). High mitochondrial accumulation of new gadolinium(III) agents within tumour cells. Chemical Communications, 50(18), 2252-2254. [More Information] Morrison, D., Aitken, J., De Jonge, M., Issa, F., Harris, H., Rendina, L. (2014). Synthesis and biological evaluation of a class of mitochondrially-targeted gadolinium(III) agents. Chemistry: A European Journal, 20(50), 16602-16612. [More Information] Wilkinson, S., Gunosewoyo, H., Barron, M., Boucher, A., McDonnell, M., Turner, P., Morrison, D., Bennett, M., McGregor, I., Rendina, L., Kassiou, M. (2014). The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity. ACS Chemical Neuroscience, 5(5), 335-339. [More Information] Austin, C., Kahlert, J., Issa, F., Reed, J., Smith, J., Ioppolo, J., Ong, J., Jamie, J., Hibbs, D., Rendina, L. (2014). The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane. Dalton Transactions, 43(28), 10719-10724. [More Information] Ioppolo, J., Bhadbhade, M., Fox, M., Rendina, L. (2013). Remarkable cage deboronation and rearrangement of a closo-1,12-dicarbadodecaborane to form a neutral nido-7,9-dicarbaundecaborane. Chemical Communications, 49(32), 3312-3314. [More Information] Ching, V., Clarke, R., Rendina, L. (2013). Supramolecular beta-cyclodextrin adducts of boron-rich DNA metallointercalators containing dicarba-closo-dodecaborane(12). Inorganic Chemistry, 52(18), 10356-10367. [More Information] Ziolkowski (Sheridan), E., Austin, C., Aitken, J., Vogt, S., Jolliffe, K., Harris, H., Rendina, L. (2013). Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells. Journal of Synchrotron Radiation, 20(2), 226-233. [More Information] Kahlert, J., Austin, C., Kassiou, M., Rendina, L. (2013). The fifth element in drug design: Boron in medicinal chemistry. Australian Journal of Chemistry, 66(10), 1118-1123. [More Information] Austin, C., Kahlert, J., Kassiou, M., Rendina, L. (2013). The translocator protein (TSPO): A novel target for cancer chemotherapy. The International Journal of Biochemistry and Cell Biology, 45(7), 1212-1216. [More Information] Banister, S., Rendina, L., Kassiou, M. (2012). 7-azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (sigma-2) receptor ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 22(12), 4059-4063. [More Information] Ching, V., Buck, D., Bhadbhade, M., Collins, J., Rendina, L. (2012). A ternary supramolecular system containing a boronated DNA-metallointercalator, beta-cyclodextrin and the hexanucleotide d(GTCGAC)(2). Chemical Communications, 48(6), 880-882. [More Information] Ching, V., Clifford, S., Bhadbhade, M., Clarke, R., Rendina, L. (2012). Synthesis and supramolecular studies of chiral boronated platinum(II) complexes: Insights into the molecular recognition of carboranes by beta-cyclodextrin. Chemistry: A European Journal, 18(45), 14413-14425. [More Information]