Payne, Richard - University of Sydney

研究领域

Research in my group is focussed on utilising the tools of chemistry to address problems of biochemical and medicinal significance. Projects are multidisciplinary in nature, involving a combination of solution- and solid-phase organic synthesis, computer-aided drug discovery, compound screening technologies. Current projects include: Rational design, synthesis and evaluation of new anti-infectives. More specifically, we are developing inhibitors that target novel pathways operating in pathogenic bacteria e.g. Mycobacterium tuberculosis (cause of TB) and parasitic organisms e.g. Plasmodium falciparum (cause of malaria). Total synthesis of glycopeptides and glycoproteins of therapeutic interest. Development of glycopeptide-based cancer vaccines.

近期论文

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Kiermaier, E., Moussion, C., Veldkamp, C., Gerardy-Schahn, R., de Vries, I., Williams, L., Chaffee, G., Phillips, A., Freiberger, F., Imre, R., Taleski, D., Payne, R., et al (2016). Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science, 351(6269), 186-190. [More Information] Rogers, S., Fey, D., McCloy, R., Parker, B., Mitchell, N., Payne, R., Daly, R., James, D., Caldon, C., Watkins, D., et al (2016). PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells. Journal of Cell Science, 129(7), 1340-1354. [More Information] Isahak, N., Sanchez, J., Perrier, S., Stone, M., Payne, R. (2016). Synthesis of polymers and nanoparticles bearing polystyrene sulfonate brushes for chemokine binding. Organic and Biomolecular Chemistry, 14(24), 5652-5658. [More Information] Williams, J., Corcilius, L., Kiefel, M., Payne, R. (2016). Total synthesis of native 5,7-diacetylpseudaminic acid from N-acetylneuraminic acid. The Journal of Organic Chemistry, 81(6), 2607-2611. [More Information] Giltrap, A., Dowman, L., Nagalingam, G., Ochoa, J., Linington, R., Britton, W., Payne, R. (2016). Total synthesis of teixobactin. Organic Letters, 18(11), 2788-2791. [More Information] Reeks, T., Jones, A., Brust, A., Sridharan, S., Corcilius, L., Wilkinson, B., Thaysen-Andersen, M., Payne, R., Kini, R., Daly, N., et al (2015). A defined alpha-helix in the bifunctional O-glycosylated natriuretic peptide TcNPa from the venom of Tropidechis carinatus. Angewandte Chemie: International Edition, 54(16), 4828-4831. [More Information] Watson, G., Gunzburg, M., Ambaye, N., Lucas, W., Traore, D., Kulkarni, K., Cergol, K., Payne, R., Panjikar, S., Pero, S., et al (2015). Cyclic peptides incorporating phosphotyrosine mimetics as potent and specific inhibitors of the Grb7 breast cancer target. Journal of Medicinal Chemistry, 58(19), 7707-7718. [More Information] Stone, M., Payne, R. (2015). Homogeneous sulfopeptides and sulfoproteins: Synthetic approaches and applications to characterize the effects of tyrosine sulfation on biochemical function. Accounts Of Chemical Research, 48(8), 2251-2261. [More Information] Malins, L., Mitchell, N., McGowan, S., Payne, R. (2015). Oxidative deselenization of selenocysteine: Applications for programmed ligation at serine. Angewandte Chemie: International Edition, 54(43), 12716-12721. [More Information] Ludeman, J., Nazari-Robati, M., Wilkinson, B., Huang, C., Payne, R., Stone, M. (2015). Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Organic and Biomolecular Chemistry, 13(7), 2162-2169. [More Information] Mitchell, N., Malins, L., Liu, X., Thompson, R., Chan, B., Radom, L., Payne, R. (2015). Rapid additive-free selenocystine-selenoester peptide ligation. Journal of the American Chemical Society, 137(44), 14011-14014. [More Information] Bashiri, G., Johnston, J., Evans, G., Bulloch, E., Goldstone, D., Jirgis, E., Kleinboelting, S., Castell, A., Ramsay, R., Manos-Turvey, A., Payne, R., et al (2015). Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex. Acta Crystallographica. Section D: Biological Crystallography, D71(11), 2297-2308. [More Information] Santhakumar, G., Payne, R. (2015). Studies toward the total synthesis and stereochemical assignment of microspinosamide. Australian Journal of Chemistry, 68(2), 1885-1889. [More Information] Payne, R., Hutton, C. (2015). SynthCon3. Australian Journal of Chemistry, 68(12), 1789-1790. [More Information] Manos-Turvey, A., Watson, E., Sykes, M., Jones, A., Baell, J., Kaiser, M., Avery, V., Payne, R. (2015). Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents. MedChemComm (Medicinal Chemistry Communications), 6(3), 403-406. [More Information] Malins, L., Giltrap, A., Dowman, L., Payne, R. (2015). Synthesis of beta-thiol phenylalanine for applications in one-pot ligation-desulfurization chemistry. Organic Letters, 17(9), 2070-2073. [More Information] Malins, L., Payne, R. (2015). Synthetic amino acids for applications in peptide ligation-desulfurization chemistry. Australian Journal of Chemistry, 68(4), 521-537. [More Information] McDonald, D., Byrne, S., Payne, R. (2015). Synthetic self-adjuvanting glycopeptide cancer vaccines. Frontiers in Chemistry, 3, 1-8. [More Information] Sayers, J., Thompson, R., Perry, K., Malins, L., Payne, R. (2015). Thiazolidine-protected beta-thiol asparagine: Applications in one-pot ligation-desulfurization chemistry. Organic Letters, 17(19), 4902-4905. [More Information] Maghzal, G., Cergol, K., Shengule, S., Suarna, C., Newington, D., Kettle, A., Payne, R., Stocker, R. (2014). Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium. The Journal of Biological Chemistry, 289(9), 5580-5595. [More Information] Malins, L., Cergol, K., Payne, R. (2014). Chemoselective sulfenylation and peptide ligation at tryptophan. Chemical Science, 5(1), 260-266. [More Information]