New, Elizabeth - University of Sydney

研究领域

Chemical biology Bioinorganic chemistry Molecular imaging Redox sensing Metal ion sensing The main research focus of the group is the development of chemical tools to assist the study of biological systems, particularly redox regulation. Many diseases are associated with perturbations in redox state, so developing ways to measure biological redox state will help us to better understand these diseases and suggest ways to cure or treat them. We are developing probes that allow the monitoring of cellular redox state by MRI or fluorescence microscopy.

近期论文

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Smith, D., Sajid, N., Rehn, S., Chandramohan, R., Carney, I., Khan, M., New, E. (2016). A library-screening approach for developing a fluorescence sensing array for the detection of metal ions. The Analyst, 141(15), 4608-4613. [More Information] Krishnamoorthy, L., Cotruvo Jr, J., Chan, J., Kaluarachchi, H., Muchenditsi, A., Pendyala, V., Jia, S., Aron, A., Ackerman, C., New, E., et al (2016). Copper regulates cyclic-AMP-dependent lipolysis. Nature Chemical Biology, 12(8), 586-592. [More Information] New, E. (2016). Harnessing the potential of small molecule intracellular fluorescent sensors. ACS Sensors, 1(4), 328-333. [More Information] Hare, D., New, E. (2016). On the outside looking in: redefining the role of analytical chemistry in the biosciences. Chemical Communications, 52(58), 8918-8934. [More Information] Kaur, A., Kolanowski, J., New, E. (2016). Reversible fluorescent probes for biological redox states. Angewandte Chemie: International Edition, 55(5), 1602-1613. [More Information] O'Neill, E., Kolanowski, J., Yin, G., Broadhouse, K., Grieve, S., Renfrew, A., Bonnitcha, P., New, E. (2016). Reversible magnetogenic cobalt complexes. RSC Advances, 6(36), 30021-30027. [More Information] Kolanowski, J., Kaur, A., New, E. (2016). Selective and reversible approaches toward imaging redox signaling using small-molecule probes. Antioxidants & Redox Signaling, 24(13), 713-730. [More Information] Kaur, A., Jankowska, K., Pilgrim, C., Fraser, S., New, E. (2016). Studies of hematopoietic cell differentiation with a ratiometric and reversible sensor of mitochondrial reactive oxygen species. Antioxidants & Redox Signaling, 24(13), 667-679. [More Information] Wilkinson, S., Sheedy, T., New, E. (2016). Synthesis and Characterization of Metal Complexes with Schiff Base Ligands. Journal of Chemical Education, 93(2), 351-354. [More Information] Kaur, A., Haghighatbin, M., Hogan, C., New, E. (2015). A FRET-based ratiometric redox probe for detecting oxidative stress by confocal microscopy, FLIM and flow cytometry. Chemical Communications, 51(52), 10510-10513. [More Information] Shen, C., Harris, B., Dawson, L., Charles (nee Slaviero), K., Hambley, T., New, E. (2015). Fluorescent sensing of monofunctional platinum species. Chemical Communications, 51(29), 6312-6314. [More Information] Hare, D., New, E., De Jonge, M., McColl, G. (2015). Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution. Chemical Society Reviews, 44, 5941-5958. [More Information] Kaur, A., Brigden, K., Cashman, T., Fraser, S., New, E. (2015). Mitochondrially targeted redox probe reveals the variations in oxidative capacity of the haematopoietic cells. Organic and Biomolecular Chemistry, 13(24), 6686-6689. [More Information] Shen, C., New, E. (2015). What has fluorescent sensing told us about copper and brain malfunction? Metallomics, 7(1), 56-65. [More Information] Yeow, J., Kaur, A., Anscomb, M., New, E. (2014). A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes. Chemical Communications, 50(60), 8181-8184. [More Information] Eljack, N., Ma, H., Drucker, J., Shen, C., Hambley, T., New, E., Friedrich, T., Clarke, R. (2014). Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin. Metallomics, 6(11), 2126-2133. [More Information] Shen, C., New, E. (2013). Promising strategies for Gd-based responsive magnetic resonance imaging contrast agents. Current Opinion In Chemical Biology, 17(2), 158-166. [More Information] New, E. (2013). Tools to study distinct metal pools in biology. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 42(9), 3210-3219. [More Information] Que, E., New, E., Chang, C. (2012). A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model. Chemical Science, 3(6), 1829-1834. [More Information] Au-Yeung, H., New, E., Chang, C. (2012). A selective reaction-based fluorescent probe for detecting cobalt in living cells. Chemical Communications, 48(43), 5268-5270. [More Information]