Lay, Peter - University of Sydney

研究领域

Cr- and Ni-induced cancers Vanadium and Cr(III) anti-diabetic drugs Ruthenium and gallium anti-cancer drugs X-ray absorption spectroscopy of drugs, biological fluids, cells and tissues Vibrational spectroscopic imaging and mapping of cells and tissues in drug treatments and understanding diseases Structural and spectroscopic studies of heme proteins Electrochemistry Copper anti-inflammatory drugs Fullerene and fulleride electrochemistry and spectroscopy Inorganic reaction mechanisms Solvation, pi-backbonding and pi-bonding effects on reactivity of transition metal complexes Bioinorganic Chemistry: Various aspects of the chemistry, biochemistry and cell biology of transition metal complexes of Cr and Ni (occupational cancers), V and Cr(III) (anti-diabetic agents), Ga and Ru (anti-cancer agents), Fe (heme proteins), and Cu (anti-inflammatory drugs) have been studied. A wide variety of spectroscopic, structural, biochemical and cell biology techniques have been employed to understand better the bioinorganic chemistry of these transition metals and to develop protective dietary protocols for metal induced cancers and to develop new potential pharmaceuticals. Biospectroscopy, Imaging, and Mapping: Complementary imaging and mapping using X-ray absorption (synchrotron-induced X-ray emission, X-ray absorption near edge-structure), proton-induced X-ray emission, vibrational (FTIR and Raman), phase-contrast (X-ray and visible), fluorescence, and other spectromicroscopies are being used to study changes in biodistributions and concentrations of elements and biochemicals in cells and tissues as a result of diseases processes and their treatment. Biospectroscopy is also being used to develop new disease diagnostics. Diseases being studied include, cancer, diabetes, graft-versus host disease, malaria, meningitis, Parkinson's disease and other bacterial and viral infections. Physical Inorganic Chemistry: A large range of spectroscopic, electrochemical and structural techniques has been used to gain fundamental insights into chemical reactivity of transition metal complexes and solvation effects on chemical reactivity. This also includes detailed studies of fullerenes and fullerides.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Puranik, R., Bao, B., Bonin, A., Kaur, R., Weder, J., Casbolt, L., Hambley, T., Lay, P., Barter, P., Rye, K. (2016). A novel class of copper(II)- and zinc(II)-bound non-steroidal anti-inflammatory drugs that inhibits acute inflammation in vivo. Cell & Bioscience, 6(1), 1-7. [More Information] Levina, A., Pham, T., Lay, P. (2016). Binding of chromium(III) to transferrin could be involved in detoxification of dietary chromium(III) rather than transport of an essential trace element. Angewandte Chemie: International Edition, 55(28), 8104-8107. [More Information] Wu, L., Levina, A., Harris, H., Cai, Z., Lai, B., Vogt, S., James, D., Lay, P. (2016). Carcinogenic chromium(VI) compounds formed by intracellular oxidation of chromium(III) dietary supplements by adipocytes. Angewandte Chemie: International Edition, 55(5), 1742-1745. [More Information] Gransbury, G., Kappen, P., Glover, C., Hughes, J., Levina, A., Lay, P., Musgrave, I., Harris, H. (2016). Comparison of KP1019 and NAMI-A in tumour-mimetic environments. Metallomics, 8(8), 762-773. [More Information] Aitken, J., Thomas, S., Armstrong, R., Lay, P., Stacker, R., Witting, P., Dillon, C., Lai, B. (2016). Investigation of indoleamine 2,3-dioxygenase using synchrotron radiation techniques. Journal of Inorganic Biochemistry, 96, 87-87. [More Information] Austin, C., Smith, T., Mostofi Zadeh Farahani, R., Hinde, K., Carter, E., Lee, J., Lay, P., Kennedy, B., Sarrafpour, B., Wright, R., Arora, M., et al (2016). Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Scientific Reports, 6, 1-11. [More Information] Bader, C., Carter, E., Safitri, A., Simpson, P., Wright, P., Stagni, S., Massi, M., Lay, P., Brooks, D., Plush, S. (2016). Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes. Molecular BioSystems, 12(7), 2064-2068. [More Information] Best, S., Levina, A., Glover, C., Johannessen, B., Kappen, P., Lay, P. (2016). XAS spectroelectrochemistry: reliable measurement of X-ray absorption spectra from redox manipulated solutions at room temperature. Journal of Synchrotron Radiation, 23(3), 743-750. [More Information] Levina, A., McLeod, A., Pulte, A., Aitken, J., Lay, P. (2015). Biotransformations of antidiabetic vanadium prodrugs in mammalian cells and cell culture media: A XANES spectroscopic study. Inorganic Chemistry, 54(14), 6707-6718. [More Information] Weeks, C., Levina, A., Fenton, R., Lay, P. (2015). EXAFS and EPR studies of the alkene oxidation catalyst species trans-[CrIII(bpb)(L)2]n+ and Crv oxidation products (bpb = N,N'-bis(2-pyridinecarboxamido)-1,2-benzene). Australian Journal of Chemistry, 68(4), 581-592. [More Information] Hackett, M., Aitken, J., El Assaad, F., McQuillan, J., Carter, E., Ball, H., Tobin, M., Paterson, D., De Jonge, M., Siegele, R., Grau, G., Hunt, N., Lay, P., et al (2015). Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites. Science Advances, 6(4), 7-16. [More Information] Levina, A., McLeod, A., Gasparini, S., Nguyen, A., De Silva, W., Aitken, J., Harris, H., Glover, C., Johannessen, B., Lay, P. (2015). Reactivity and speciation of anti-diabetic vanadium complexes in whole blood and its components: The important role of red blood cells. Inorganic Chemistry, 54(16), 7753-7766. [More Information] Kremer, L., McLeod, A., Aitken, J., Levina, A., Lay, P. (2015). Vanadium(V) and -(IV) complexes of anionic polysaccharides: Controlled release pharmaceutical formulations and models of vanadium biotransformation products. Journal of Inorganic Biochemistry, 147, 227-234. [More Information] Levina, A., Lay, P. (2014). Influence of an anti-metastatic ruthenium(III) prodrug on extracellular protein-protein interactions: studies by bio-layer interferometry. Inorganic Chemistry Frontiers, 1(1), 44-48. [More Information] Kong, S., Chan, B., Park, J., Hill, K., Aitken, J., Cottle, L., Farghaian, H., Cole, A., Lay, P., Sue, C., et al (2014). Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes alpha-Synuclein externalization via exosomes. Human Molecular Genetics, 23(11), 2816-2833. [More Information] Levina, A., McLeod, A., Kremer, L., Aitken, J., Glover, C., Johannessen, B., Lay, P. (2014). Reactivity-activity relationships of oral anti-diabetic vanadium complexes in gastrointestinal media: an X-ray absorption spectroscopic study. Metallomics, 6(10), 1880-1888. [More Information] Pham, T., Aitken, J., Levina, A., Lay, P. (2014). Solid-state structural studies of chromium(III) nicotinato nutritional supplements. Inorganic Chemistry, 53(19), 10685-10694. [More Information] Liang, J., Levina, A., Lay, P. (2014). Synthesis and in-vitro evaluation of anticancer RH(III) complexes. Asia-Pacific Journal of Clinical Oncology, 10(S7), 35-35. Aitken, J., Austin, C., Hunt, N., Ball, H., Lay, P. (2014). The Fe-heme structure of met-indoleamine 2,3-dioxygenase-2 determined by X-ray absorption fine structure. Biochemical and Biophysical Research Communications, 450(1), 25-29. [More Information] Safitria, A., Levina, A., Lay, P. (2014). The role of transition metals in protein phosphorylation in human health and diseases. Asia-Pacific Journal of Clinical Oncology, 10(S7), 41-41.