Hambley, Trevor - University of Sydney

研究领域

Medicinal inorganic chemistry, in particular, Pt anticancer drugs Investigating the relationship between the reduction potentials of Pt(IV) complexes and their biological activity Investigating methods for controlling the physical and biological properties of platinum(IV) complexes Development of synchrotron radiation based methods for the in situ determination of oxidation states of platinum in biological environments and for reliably determining platinum distributions in these environments Investigation of cobalt complexes as delivery agents for matrix metalloproteinase inhibitors and other anticancer agents Employing XANES technique to determine oxidation states of the cobalt complexes in solution Investigating and optimizing anticancer drug uptake in solid tumours and tumour models. Please see our home page for detailed coverage of our research activities.

近期论文

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Puranik, R., Bao, B., Bonin, A., Kaur, R., Weder, J., Casbolt, L., Hambley, T., Lay, P., Barter, P., Rye, K. (2016). A novel class of copper(II)- and zinc(II)-bound non-steroidal anti-inflammatory drugs that inhibits acute inflammation in vivo. Cell & Bioscience, 6(1), 1-7. [More Information] Renfrew, A., Bryce, N., Hambley, T. (2015). Cobalt(III) chaperone complexes of curcumin: Photoreduction, cellular accumulation and light-selective toxicity towards tumour cells. Chemistry - A European Journal, 21(43), 15224-15234. [More Information] Shen, C., Harris, B., Dawson, L., Charles (nee Slaviero), K., Hambley, T., New, E. (2015). Fluorescent sensing of monofunctional platinum species. Chemical Communications, 51(29), 6312-6314. [More Information] Roberts, M., Pham, T., Doan, J., Jiang, C., Hambley, T., Greguric, I., Fraser, B. (2015). Radiosynthesis and 'click' conjugation of ethynyl-4-[18F]fluorobenze - an improved [18F]synthon for indirect radiolabeling. Journal of Labelled Compounds and Radiopharmaceuticals, 58(13-14), 473-478. [More Information] Eljack, N., Ma, H., Drucker, J., Shen, C., Hambley, T., New, E., Friedrich, T., Clarke, R. (2014). Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin. Metallomics, 6(11), 2126-2133. [More Information] Renfrew, A., Bryce, N., Hambley, T. (2013). Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study. Chemical Science, 4(9), 3731-3739. [More Information] Zhang, J., Bonnitcha, P., Wexselblatt, E., Klein, A., Najajreh, Y., Gibson, D., Hambley, T. (2013). Facile preparation of mono-, di- and mixed-carboxylato platinum(IV) complexes for versatile anticancer prodrug design. Chemistry: A European Journal, 19(5), 1672-1676. [More Information] Chen, C., Zhang, J., Aitken, J., Hambley, T. (2013). Influence of equatorial and axial carboxylato ligands on the kinetic inertness of platinum(IV) complexes in the presence of ascorbate and cysteine and within DLD-1 cancer cells. Journal of Medicinal Chemistry, 56(21), 8757-8764. [More Information] Roberts, M., Pham, T., Doan, J., Fraser, B., Hambley, T., Greguric, I. (2013). Radiosynthesis of [18F]-ethynyl-4-fluorobenzene for click conjugation. Journal of Labelled Compounds and Radiopharmaceuticals, 56(S1), P091-P091. Bryce, N., Pham, B., Fong, N., Jain, N., Pan, E., Whan, R., Hambley, T., Hawkett, B. (2013). The composition and end-group functionality of sterically stabilized nanoparticles enhances the effectiveness of co-administered cytotoxins. Biomaterials Science, 1(12), 1260-1272. [More Information] Bonnitcha, P., Kim, B., Hocking, R., Clegg, J., Turner, P., Neville, S., Hambley, T. (2012). Cobalt complexes with tripodal ligands: Implications for the design of drug chaperones. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 41(37), 11293-11304. [More Information] Bonnitcha, P., Kim, B., Hocking, R., Clegg, J., Turner, P., Neville, S., Hambley, T. (2012). Cobalt complexes with tripodal ligands: implications for the design of drug chaperones. Dalton Transactions, 41(37), 11293-11304. [More Information] Yamamoto, N., Renfrew, A., Kim, B., Bryce, N., Hambley, T. (2012). Dual Targeting of Hypoxic and Acidic Tumor Environments with a Cobalt(III) Chaperone Complex. Journal of Medicinal Chemistry, 55(24), 11013-11021. [More Information] Yamamoto, N., Bryce, N., Metzler-Nolte, N., Hambley, T. (2012). Effects of enzymatic activation on the distribution of fluorescently tagged MMP-2 cleavable peptides in cancer cells and spheroids. Bioconjugate Chemistry, 23(6), 1110-1118. [More Information] Zhang, J., Bryce, N., Lanzirotti, A., Chen, C., Paterson, D., De Jonge, M., Howard, D., Hambley, T. (2012). Getting to the core of platinum drug bio-distributions: the penetration of anti-cancer platinum complexes into spheroid tumour models. Metallomics, 4(11), 1209-1217. [More Information] Zhang, J., Wexselblatt, E., Hambley, T., Gibson, D. (2012). Pt(IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate. Chemical Communications, 48(6), 847-849. [More Information] Hall, M., Daly, H., Zhang, J., Zhang, M., Alderden, R., Pursche, D., Foran, G., Hambley, T. (2012). Quantitative measurement of the reduction of platinum(IV) complexes using X-ray absorption near-edge spectroscopy (XANES). Metallomics, 4(6), 568-575. [More Information] Failes, T., Battle, A., Chen, C., Cullinane, C., Woods, R., Elliott, R., Deacon, G., Hambley, T. (2012). Structural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: The importance of pKa matching. Journal of Inorganic Biochemistry, 115, 220-225. [More Information] Guo, S., Mason, D., Turland, S., Lawrenz, E., Kelly, L., Fallon, G., Gatehouse, B., Bond, A., Deacon, G., Battle, A., Hambley, T., et al (2012). Systematic differences in electrochemical reduction of the structurally characterized anti-cancer platinum(IV) complexes [Pt{((p-HC6F4)NCH2)2}-(pyridine)2Cl2], [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)2], and [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)Cl]. Journal of Inorganic Biochemistry, 115(2012), 226-239. [More Information] Zhang, J., Bryce, N., Siegele, R., Carter, E., Paterson, D., De Jonge, M., Howard, D., Ryan, C., Hambley, T. (2012). The use of spectroscopic imaging and mapping techniques in the characterisation and study of DLD-1 cell spheroid tumour models. Integrative Biology, 4(9), 1072-1080. [More Information]