Zhou, Fanfan - University of Sydney

研究领域

Drug transporters are the functional cell surface membrane proteins, which are playing critical roles in drug absorption, distribution and elimination. Because of their unique characters to transport structural specific drugs, they have been widely studied as the targets of drug development. My research interests are to explore the molecular regulation of critical solute carrier drug transporter families (SLCs) as well as the influenc of the SLCpharmacogenetic variations on pharmacokinetic performance of various drugs, such as anti-HIV drugs, antibiotics and anti-cancer drugs. My research work will contribute to: Investigate the regulatory mechanisms of SLCtransporters. Elucidate the roles ofSLC transporters played in drug absorption and disposition. Explore the interactions of a wide range of clinical relevant compounds with SLC transporters. Demonstrate therelationship betweenSLC pharmacogenetic variations and drug pharmacokinetic performance.

近期论文

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Chan, T., Cheung, F., Zheng, J., Lu, X., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2016). Casein Kinase 2 Is a Novel Regulator of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Trafficking. Molecular Pharmaceutics, 13(1), 144-154. [More Information] Xu, C., Zhu, L., Chan, T., Lu, X., Shen, W., Madigan, M., Gillies, M., Zhou, F. (2016). Chloroquine and Hydroxychloroquine Are Novel Inhibitors of Human Organic Anion Transporting Polypeptide 1A2. Journal of Pharmaceutical Sciences, 105(2), 884-890. [More Information] Zhu, X., Wang, K., Zhang, K., Xu, F., Yin, Y., Zhu, L., Zhou, F. (2016). Galectin-1 knockdown in carcinoma-associated fibroblasts inhibits migration and invasion of human MDA-MB-231 breast cancer cells by modulating MMP-9 expression. Acta Biochimica et Biophysica Sinica, 29(4), 462-467. [More Information] Wang, K., Zhu, X., Zhang, K., Zhou, F., Zhu, L. (2016). Gas1 Knockdown Increases the Neuroprotective Effect of Glial Cell-Derived Neurotrophic Factor Against Glutamate-Induced Cell Injury in Human SH-SY5Y Neuroblastoma Cells. Cellular and Molecular Neurobiology, 36(4), 603-611. [More Information] Lu, X., Chan, T., Xu, C., Zhu, L., Zhou, Q., Roberts, K., Chan, K., Li, J., Zhou, F. (2016). Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins. Journal of Antimicrobial Chemotherapy, 71(2), 403-412. [More Information] Wang, K., Zhu, X., Zhang, K., Wu, Z., Sun, S., Zhou, F., Zhu, L. (2016). Neuroprotective effect of Puerarin on glutamate-induced cytotoxicity in differentiated Y-79 cells via inhibition of ROS generation and Ca²�?� influx. International Journal of Molecular Sciences, 17(7), 1-13. [More Information] Zhu, X., Wang, K., Zhang, K., Lin, X., Zhu, L., Zhou, F. (2016). Puerarin Protects Human Neuroblastoma SH-SY5Y Cells against Glutamate-Induced Oxidative Stress and Mitochondrial Dysfunction. Journal of Biochemical and Molecular Toxicology, 30(1), 22-28. [More Information] Zheng, J., Chan, T., Zhu, L., Yan, X., Cao, Z., Wang, Y., Zhou, F. (2016). The inhibitory effects of camptothecin (CPT) and its derivatives on the substrate uptakes mediated by human solute carrier transporters (SLCs). Xenobiotica, 46(9), 831-840. [More Information] Wang, K., Xie, M., Zhu, L., Zhu, X., Zhang, K., Zhou, F. (2015). Ciliary neurotrophic factor protects SH-SY5Y neuroblastoma cells against A-Beta1-42-induced neurotoxicity via activating the JAK2/STAT3 axis. Folia Neuropathologica, 53(3), 226-235. [More Information] Zhu, L., Shen, W., Lyons, B., Wang, Y., Zhou, F., Gillies, M. (2015). Dysregulation of inter-photoreceptor retinoid-binding protein (IRBP) after induced Muller cell disruption. Journal of Neurochemistry, 133(6), 909-918. [More Information] Zhu, X., Liu, A., Zhang, K., Wang, K., Gao, Y., Zhou, F., Zhu, L. (2015). High-yield soluble expression of recombinant human interleukin-1β in Escherichia coli. Romanian Biotechnology Letters, 20(1), 10114-10122. Chan, T., Zhu, L., Madigan, M., Wang, K., Shen, W., Gillies, M., Zhou, F. (2015). Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells. British Journal of Pharmacology, 172(9), 2343-2353. [More Information] Chan, T., Zheng, J., Zhu, L., Grewal, T., Murray, M., Zhou, F. (2015). Putative Transmembrane Domain 6 of the Human Organic Anion Transporting Polypeptide 1A2 (OATP1A2) Influences Transporter Substrate Binding, Protein Trafficking, and Quality Control. Molecular Pharmaceutics, 12(1), 111-119. [More Information] Zhu, X., Wang, K., Zhang, K., Tan, X., Wu, Z., Sun, S., Zhou, F., Zhu, L. (2015). Tetramethylpyrazine Protects Retinal Capillary Endothelial Cells (TR-iBRB2) against IL-1B-Induced Nitrative/Oxidative Stress. International Journal of Molecular Sciences, 16(9), 21775-21790. [More Information] Xu, C., Zhu, L., Chan, T., Lu, X., Shen, W., Gillies, M., Zhou, F. (2015). The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic mice. PloS One, 10(3), 1-14. [More Information] Ren, T., Han, Z., Yang, C., Hang, Y., Fang, D., Wang, K., Zhu, X., Ji, X., Zhou, F. (2014). Association of SLC22A4 gene polymorphism with Rheumatoid arthritis in the Chinese population. Journal of Biochemical and Molecular Toxicology, 28(5), 206-210. [More Information] Wang, K., Zhou, F., Zhu, L., Zhu, X., Zhang, K., Zhu, L. (2014). High level soluble expression, purification, and characterization of human ciliary neruonotrophic factor in Escherichia coli by single protein production system. Protein Expression and Purification, 96, 8-13. [More Information] Li, Z., Cheung, F., Zheng, J., Chan, T., Zhu, L., Zhou, F. (2014). Interaction of the Bioactive Flavonol, Icariin, with the Essential Human Solute Carrier Transporters. Journal of Biochemical and Molecular Toxicology, 28(2), 91-97. [More Information] Li, Z., Wang, K., Zheng, J., Cheung, F., Chan, T., Zhu, L., Zhou, F. (2014). Interactions of the active components of Punica granatum (pomegranate) with the essential renal and hepatic human Solute Carrier transporters. Pharmaceutical Biology, 52(12), 1510-1517. [More Information] Wang, K., Zhu, X., Zhang, K., Zhu, L., Zhou, F. (2014). Investigation of gallic acid induced anticancer effect in human breast carcinoma MCF-7 cells. Journal of Biochemical and Molecular Toxicology, 28(9), 387-393. [More Information]