Varamini, Pegah - University of Sydney

研究领域

Dr Varamini’s research interests are in different areas of pharmaceutical sciences including peptide chemistry and peptide delivery, pharmacology of neuropeptide hormones, endogenous antineuropathic peptides and anticancer therapeutics, peptide-based subunit vaccine delivery, and natural product chemistry and pharmacology. Her current research focuses on targeted delivery of highly potent antineoplastic agents to breast cancer cells for the treatment of Triple Negative Breast Cancer (TNBC) via some overexpressed receptors (“Trojan Horse” approach).

近期论文

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Varamini, P., Toth, I. (2016). Recent advances in oral delivery of peptide hormones. Expert Opinion on Drug Delivery, 13(4), 507-522. [More Information] Goodwin, D., Varamini, P., Simerska, P., D'Occhio, M., Toth, I. (2015). Design, synthesis and evaluation of a gonadotropin releasing hormone-based subunit vaccine in rams (Ovis aries). Vaccine, 33(12), 1453-1458. [More Information] Moradi, S., Varamini, P., Toth, I. (2015). Evaluation of the Biological Properties and the Enzymatic Stability of Glycosylated Luteinizing Hormone-Releasing Hormone Analogs. The AAPS Journal, 17(5), 1135-1143. [More Information] Chang, C., Varamini, P., Giddam, A., Mansfeld, F., D'Occhio, M., Toth, I. (2015). Investigation of Structure–Activity Relationships of Synthetic Anti-Gonadotropin Releasing Hormone Vaccine Candidates. ChemMedChem: chemistry enabling drug discovery, 10(5), 901-910. [More Information] Goodwin, D., Simerska, P., Chang, C., Mansfeld, F., Varamini, P., D'Occhio, M., Toth, I. (2014). Active immunisation of mice with GnRH lipopeptide vaccine candidates: Importance of T helper or multi-dimer GnRH epitope. Bioorganic and Medicinal Chemistry, 22(17), 4848-4854. [More Information] Moradi, S., Varamini, P., Toth, I. (2014). The transport and efflux of glycosylated luteinising hormone-releasing hormone analogues in Caco-2 cell model: Contributions of glucose transporters and efflux systems. Journal of Pharmaceutical Sciences, 103(10), 3217-3224. [More Information] Varamini, P., Toth, I. (2013). Lipid- and sugar-modified endomorphins: novel targets for the treatment of neuropathic pain. Frontiers in Pharmacology, 4, 1-7. [More Information]