Tang, Patricia - University of Sydney

研究领域

Dr Tang has extensive skills in characterisation of particles, including: dispersibility of drug powders using various impaction methods; determination of surface and mass fractal dimensions using light diffraction; particle sizing (using light diffraction, time-of-flight instrument); x-ray diffraction; scanning and transmission electron microscope imaging techniques; and focused ion-beam imaging to see internal structure of particles. She has been involved in various collaboration projects with: Intensive Care Units, Royal Prince Alfred Hospital (Sydney) to develop an in-line device for administering dry powder mannitol to ventilated patients for the clearance of mucus from lungs. Prince Charles Hospital (Brisbane) to characterise antibiotic droplets’ particle size distribution and mass output when the drug is nebulised in line with a ventilator. Center for Neuro-Medicine, Korea Institute of Science and Technology, to synthesise liposome and characterisation of the droplet’s size when administered using a micro-sprayer. School of Health Science, The University of Wollongong to prepare a stable form of beta-glucan extracted from shiitake mushroom for the prevention of colon cancer. She has been successful in producing inhalable and stable drug compounds by ultrasonic precipitation, confined liquid impinging jet crystallisation, vortex mixer precipitation, high gravity reaction, spray drying and freeze drying.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Leung, S., Parumasivam, T., Tang, P., Chan, K. (2016). A Proof-of-Principle Setup for Delivery of Relenza® (Zanamivir) Inhalation Powder to Intubated Patients. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(1), 30-35. [More Information] Li, L., Sun, S., Parumasivam, T., Denman, J., Gengenbach, T., Tang, P., Mao, S., Chan, K. (2016). l-Leucine as an excipient against moisture on in vitro aerosolization performances of highly hygroscopic spray-dried powders. European Journal of Pharmaceutics and Biopharmaceutics, 102, 132-141. [More Information] Leung, S., Parumasivam, T., Tang, P., Chan, K. (2016). Response to Letter to the Editor: Pulmonary Delivery of Dry Powders During Invasive Mechanical Ventilation: Innovations Are Required. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 29(2), 217-217. [More Information] Tang, P., Leung, S., Hor, E., Ruzycki, C., Carrigy, N., Finlay, W., Brannan, J., Devadason, S., Anderson, S., Sly, P., Samnick, K., Chan, K. (2015). An Apparatus to Deliver Mannitol Powder for Bronchial Provocation in Children Under Six Years Old. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 28(6), 452-461. [More Information] Leung, S., Tang, P., Zhou, Q., Tong, Z., Leung, C., Decharaksa, J., Yang, R., Chan, K. (2015). De-agglomeration Effect of the US Pharmacopeia and Alberta Throats on Carrier-Based Powders in Commercial Inhalation Products. The AAPS Journal, 17(6), 1407-1416. [More Information] Zhou, Q., Leung, S., Tang, P., Parumasivam, T., Loh, Z., Chan, K. (2015). Inhaled formulations and pulmonary drug delivery systems for respiratory infections. Advanced Drug Delivery Reviews, 85, 83-89. [More Information] Zhou, Q., Tang, P., Leung, S., Chan, J., Chan, K. (2014). Emerging inhalation aerosol devices and strategies: Where are we headed? Advanced Drug Delivery Reviews, 75, 3-17. [More Information] Liang, W., Kwok, P., Chow, M., Tang, P., Mason, A., Chan, K., Lam, J. (2014). Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids. European Journal of Pharmaceutics and Biopharmaceutics, 86(1), 64-73. [More Information] Zhou, Q., Tong, Z., Tang, P., Citterio, M., Yang, R., Chan, K. (2013). Effect of Device Design on the Aerosolization of a Carrier-Based Dry Powder Inhaler - A Case Study on Aerolizer® Foradile®. The AAPS Journal, 15(2), 511-522. [More Information] Tang, P., Kwok, P., Tong, Z., Yang, R., Raper, J., Chan, K. (2012). Does the United States Pharmacopeia Throat Introduce De-agglomeration of Carrier-Free Powder from Inhalers? Pharmaceutical Research, 29(7), 1797-1807. [More Information] Handayani, D., Meyer, B., Chen, J., Tang, P., Kwok, P., Chan, K., Huang, X. (2012). The comparison of the effect of oat and Shiitake mushroom powder to prevent body weight gain in rats fed high fat diet. Food and Nutrition Sciences, 3(7), 1009-1019. [More Information] Syed Muhammad, S., Tang, P., Chan, K., Dehghani, F. (2012). The effect of lactose micro-spherical crystals prepared by conditioning with supercritical fluid on salbutamol sulphate inhalation performance. Journal of Supercritical Fluids, 71, 92-101. [More Information] Tang, P., Chan, K., Rajbhandari, D., Phipps, P. (2011). Method to Introduce Mannitol Powder to Intubated Patients to Improve Sputum Clearance. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 24(1), 1-9. [More Information] Syed Muhammad, S., Langrish, T., Tang, P., Adi, H., Chan, K., Kazarian, S., Dehghani, F. (2010). A novel method for the production of crystalline micronised particles. International Journal of Pharmaceutics, 388(1-2), 114-122. [More Information] Tang, P., Chan, K., Chiou, H., Ogawa, K., Jones, M., Adi, H., Buckton, G., Prud'homme, R., Raper, J. (2009). Characterisation and aerosolisation of mannitol particles produced via confined liquid impinging jets. International Journal of Pharmaceutics, 367, 51-57. [More Information] Tang, P., Chan, K., Raper, J. (2009). Validation of computation method to predict aerodynamic diameter of particles with rough surface. Powder Technology, 192(1), 74-84. [More Information] Adi, S., Adi, H., Tang, P., Traini, D., Chan, K., Young, P. (2008). Micro-particle corrugation, adhesion and inhalation aerosol efficiency. European Journal of Pharmaceutical Sciences, 35(1-2), 12-18. [More Information] Tang, P., Fletcher, D., Chan, K., Raper, J. (2008). Simple and cost-effective powder disperser for aerosol particle size measurement. Powder Technology, 187(1), 27-36. [More Information] Heng, D., Tang, P., Cairney, J., Chan, K., Cutler, D., Salama, R., Yun, J. (2007). Focused-ion-beam Milling: A Novel Approach to Probing the Interior of Particles Used for Inhalation Aerosols. Pharmaceutical Research, 24(9), 1608-1617. [More Information] Abbas, A., Srour, M., Tang, P., Chiou, H., Chan, K., Romagnoli, J. (2007). Sonocrystallization of sodium chloride particles for inhalation. Chemical Engineering Science, 62(9), 2445-2453. [More Information] Tang, P., Chan, K., Tam, E., de Gruyter, N., Chan, J. (2006). Preparation of NaCl powder suitable for inhalation. Industrial and Engineering Chemistry Research, 45(12), 4188-4192. Chew, N., Tang, P., Chan, K., Raper, J. (2005). How much particle surface corrugation is sufficient to improve aerosol performance of powders? Pharmaceutical Research. [More Information] Tang, P., Chan, K., Raper, J. (2004). Prediction Of Aerodynamic Diameter Of Particles With Rough Surfaces. Powder Technology, 147(1-3), 64-78.